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Glucose counterregulation in diabetes secondary to chronic pancreatitis

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Harvard

Larsen, S, Hilsted, J, Philipsen, EK, Tronier, B, Christensen, NJ, Damkjaer Nielsen, M & Worning, H 1990, 'Glucose counterregulation in diabetes secondary to chronic pancreatitis' Metabolism: Clinical and Experimental, bind 39, nr. 2, s. 138-43.

APA

Larsen, S., Hilsted, J., Philipsen, E. K., Tronier, B., Christensen, N. J., Damkjaer Nielsen, M., & Worning, H. (1990). Glucose counterregulation in diabetes secondary to chronic pancreatitis. Metabolism: Clinical and Experimental, 39(2), 138-43.

CBE

MLA

Vancouver

Author

Larsen, S ; Hilsted, J ; Philipsen, E K ; Tronier, B ; Christensen, N J ; Damkjaer Nielsen, M ; Worning, H. / Glucose counterregulation in diabetes secondary to chronic pancreatitis. I: Metabolism: Clinical and Experimental. 1990 ; Bind 39, Nr. 2. s. 138-43.

Bibtex

@article{d5a3d188d8c74ab99bbf64b035fe8923,
title = "Glucose counterregulation in diabetes secondary to chronic pancreatitis",
abstract = "Glucose counterregulation and hormonal responses after insulin-induced hypoglycemia were investigated in six patients with diabetes mellitus secondary to chronic pancreatitis, in seven with insulin-dependent (type I) diabetes mellitus, and in seven healthy subjects. Glucose counterregulation was identical in type I patients and in the patients with chronic pancreatitis, whereas both groups had impaired glucose recovery compared with the healthy subjects. The patients with chronic pancreatitis had no glucagon response to hypoglycemia, whereas epinephrine increased significantly. In an additional experiment, glucose recovery did not occur after hypoglycemia during concomitant beta-adrenoceptor blockade in these patients. In conclusion, glucose counterregulation is preserved but slightly impaired in patients with diabetes secondary to chronic pancreatitis, and the combination of total glucagon deficiency and pharmacological blockade of the metabolic actions of circulating epinephrine abolishes glucose counterregulation after hypoglycemia.",
keywords = "Adrenergic beta-Antagonists, Blood Glucose, Blood Pressure, Diabetes Mellitus, Diabetes Mellitus, Type 1, Female, Glucagon, Glycerol, Heart Rate, Hormones, Humans, Hydroxybutyrates, Hypoglycemia, Insulin, Lactates, Male, Middle Aged, Pancreatic Polypeptide, Pancreatitis",
author = "S Larsen and J Hilsted and Philipsen, {E K} and B Tronier and Christensen, {N J} and {Damkjaer Nielsen}, M and H Worning",
year = "1990",
month = "2",
language = "English",
volume = "39",
pages = "138--43",
journal = "Metabolism",
issn = "0026-0495",
publisher = "W.B./Saunders Co",
number = "2",

}

RIS

TY - JOUR

T1 - Glucose counterregulation in diabetes secondary to chronic pancreatitis

AU - Larsen, S

AU - Hilsted, J

AU - Philipsen, E K

AU - Tronier, B

AU - Christensen, N J

AU - Damkjaer Nielsen, M

AU - Worning, H

PY - 1990/2

Y1 - 1990/2

N2 - Glucose counterregulation and hormonal responses after insulin-induced hypoglycemia were investigated in six patients with diabetes mellitus secondary to chronic pancreatitis, in seven with insulin-dependent (type I) diabetes mellitus, and in seven healthy subjects. Glucose counterregulation was identical in type I patients and in the patients with chronic pancreatitis, whereas both groups had impaired glucose recovery compared with the healthy subjects. The patients with chronic pancreatitis had no glucagon response to hypoglycemia, whereas epinephrine increased significantly. In an additional experiment, glucose recovery did not occur after hypoglycemia during concomitant beta-adrenoceptor blockade in these patients. In conclusion, glucose counterregulation is preserved but slightly impaired in patients with diabetes secondary to chronic pancreatitis, and the combination of total glucagon deficiency and pharmacological blockade of the metabolic actions of circulating epinephrine abolishes glucose counterregulation after hypoglycemia.

AB - Glucose counterregulation and hormonal responses after insulin-induced hypoglycemia were investigated in six patients with diabetes mellitus secondary to chronic pancreatitis, in seven with insulin-dependent (type I) diabetes mellitus, and in seven healthy subjects. Glucose counterregulation was identical in type I patients and in the patients with chronic pancreatitis, whereas both groups had impaired glucose recovery compared with the healthy subjects. The patients with chronic pancreatitis had no glucagon response to hypoglycemia, whereas epinephrine increased significantly. In an additional experiment, glucose recovery did not occur after hypoglycemia during concomitant beta-adrenoceptor blockade in these patients. In conclusion, glucose counterregulation is preserved but slightly impaired in patients with diabetes secondary to chronic pancreatitis, and the combination of total glucagon deficiency and pharmacological blockade of the metabolic actions of circulating epinephrine abolishes glucose counterregulation after hypoglycemia.

KW - Adrenergic beta-Antagonists

KW - Blood Glucose

KW - Blood Pressure

KW - Diabetes Mellitus

KW - Diabetes Mellitus, Type 1

KW - Female

KW - Glucagon

KW - Glycerol

KW - Heart Rate

KW - Hormones

KW - Humans

KW - Hydroxybutyrates

KW - Hypoglycemia

KW - Insulin

KW - Lactates

KW - Male

KW - Middle Aged

KW - Pancreatic Polypeptide

KW - Pancreatitis

M3 - Journal article

VL - 39

SP - 138

EP - 143

JO - Metabolism

JF - Metabolism

SN - 0026-0495

IS - 2

ER -

ID: 40238210