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Glucocorticoids promote a glioma stem cell-like phenotype and resistance to chemotherapy in human glioblastoma primary cells: Biological and prognostic significance

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  1. Breast cancer rate after oophorectomy: A Prospective Danish Cohort Study

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  2. Testicular cancer incidence predictions in Europe 2010–2035: A rising burden despite population ageing

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  3. Menstrual pain and risk of epithelial ovarian cancer: Results from the Ovarian Cancer Association Consortium

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  4. Tibolone and risk of gynecological hormone sensitive cancer

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  5. Does HPV status influence survival after vulvar cancer?

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  1. Long-Term Follow-Up and Predictors of Functional Outcome after Surgery for Spinal Meningiomas: A Population-Based Cohort Study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Risk factors for need of reoperation in bilateral chronic subdural haematomas

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Development and external validation of a clinical prediction model for functional impairment after intracranial tumor surgery

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  • Ourania N Kostopoulou
  • Abdul-Aleem Mohammad
  • Jiri Bartek
  • Julia Winter
  • Masany Jung
  • Giuseppe Stragliotto
  • Cecilia Söderberg-Nauclér
  • Natalia Landázuri
Vis graf over relationer

Glioma stem cells (GSCs) are glioblastoma (GBM) cells that are resistant to therapy and can give rise to recurrent tumors. The identification of patient-related factors that support GSCs is thus necessary to design effective therapies for GBM patients. Glucocorticoids (GCs) are used to treat GBM-associated edema. However, glucocorticoids participate in the physiological response to psychosocial stress, which has been linked to poor cancer prognosis. This raises concern that glucocorticoids affect the tumor and GSCs. Here, we treated primary human GBM cells with dexamethasone and evaluated GC-driven changes in cell morphology, proliferation, migration, gene expression, secretory activity and growth as neurospheres. Dexamethasone treatment of GBM cells appeared to promote the development of a GSC-like phenotype and conferred resistance to physiological stress and chemotherapy. We also analyzed a potential correlation between GC treatment and tumor recurrence after surgical excision in a population-based consecutive cohort of 48 GBM patients, adjusted for differences in known prognostic factors concerning baseline and treatment characteristics. In this cohort, we found a negative correlation between GC intake and progression-free survival, regardless of the MGMT methylation status. In conclusion, our findings raise concern that treatment of GBM with GCs may compromise the efficacy of chemotherapy and may support a GSC population, which could contribute to tumor recurrence and the poor prognosis of the disease.

OriginalsprogEngelsk
TidsskriftRadiation Oncology Investigations
Vol/bind142
Udgave nummer6
Sider (fra-til)1266-1276
ISSN0020-7136
DOI
StatusUdgivet - 2018

ID: 52379374