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Udgivet

Glucagon-like peptide-2 induces rapid digestive adaptation following intestinal resection in preterm neonates

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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  • Andreas Vegge
  • Thomas Thymann
  • Pernille Lund
  • Barbara Stoll
  • Stine Brandt Bering
  • Bolette Hartmann
  • Jacob Jelsing
  • Niels Qvist
  • Douglas G Burrin
  • Palle B Jeppesen
  • Jens Juul Holst
  • Per Torp Sangild
Vis graf over relationer
Short bowel syndrome (SBS) is a frequent complication after intestinal resection in infants suffering from intestinal disease. We tested whether treatment with the intestinotrophic hormone glucagon-like peptide-2 (GLP-2) increases intestinal volume and function in the period immediately following intestinal resection in preterm pigs. Preterm pigs were fed enterally for 48 h before undergoing resection of 50% of the small intestine and establishment of a jejunostomy. Following resection, pigs were maintained on total parenteral nutrition (TPN) without (SBS, n = 8) or with GLP-2 treatment (3.5 μg/kg body wt per h, SBS+GLP-2, n = 7) and compared with a group of unresected preterm pigs (control, n = 5). After 5 days of TPN, all piglets were fed enterally for 24 h, and a nutrient balance study was performed. Intestinal resection was associated with markedly reduced endogenous GLP-2 levels. GLP-2 increased the relative absorption of wet weight (46 vs. 22%), energy (79 vs. 64%), and all macronutrients (all parameters P
OriginalsprogEngelsk
TidsskriftAmerican Journal of Physiology: Gastrointestinal and Liver Physiology
Vol/bind305
Udgave nummer4
Sider (fra-til)G277-85
ISSN0193-1857
DOI
StatusUdgivet - 15 aug. 2013

ID: 42486632