Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Ghrelin secretion in humans - a role for the vagus nerve?

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. How does meal composition influence the evaluation of gastrointestinal motility measured by the wireless motility capsule?

    Publikation: Bidrag til tidsskriftKonferenceabstrakt i tidsskriftForskningpeer review

  2. Gastrointestinal motility in patients with end-stage renal disease on chronic hemodialysis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Regional gastrointestinal pH profile is altered in patients with type 1 diabetes and peripheral neuropathy

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Transcutaneous cervical vagal nerve stimulation modulates cardiac vagal tone and tumor necrosis factor-alpha

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

BACKGROUND: Ghrelin, an orexigenic peptide, is secreted from endocrine cells in the gastric mucosa. Circulating levels rise in the preprandial phase, suggesting an anticipatory or cephalic phase of release, and decline in the postprandial phase, suggesting either the loss of a stimulatory factor or inhibition by factors released when nutrients enter the intestine. We hypothesized that vagal signals are not required for the (i) preprandial increase or (ii) postprandial suppression of ghrelin levels. Further, we wanted to investigate the hypothesis that (iii) glucagon-like peptide-1 might be implicated in the postprandial decline in ghrelin levels.

METHODS: We measured ghrelin levels in plasma from sham-feeding and meal studies carried out in vagotomized individuals and controls, and from a GLP-1 infusion study carried out in fasting healthy young individuals.

KEY RESULTS: We find that (i) ghrelin secretion is unchanged during indirect vagal stimulation as elicited by modified sham-feeding in vagotomized individuals and matched controls, (ii) ghrelin secretion is similarly suppressed after meal ingestion in vagotomized individuals and controls, and (iii) infusion of GLP-1 does not lower ghrelin levels.

CONCLUSIONS & INFERENCES: We conclude that for postprandial suppression of circulating ghrelin levels, a circulating factor (but not GLP-1) or short (duodeno-gastric) reflexes seem to be implicated.

OriginalsprogEngelsk
TidsskriftNeurogastroenterology and Motility
Vol/bind30
Udgave nummer6
Sider (fra-til)e13295
ISSN1350-1925
DOI
StatusUdgivet - jun. 2018

ID: 52643228