TY - JOUR
T1 - Getting to grips with endoscopy - Learning endoscopic surgical skills induces bi-hemispheric plasticity of the grasping network
AU - Karabanov, Anke Ninija
AU - Irmen, Friederike
AU - Madsen, Kristoffer Hougaard
AU - Haagensen, Brian Numelin
AU - Schulze, Svend
AU - Bisgaard, Thue
AU - Siebner, Hartwig Roman
N1 - Copyright © 2018. Published by Elsevier Inc.
PY - 2019/4/1
Y1 - 2019/4/1
N2 - Endoscopic surgery requires skilled bimanual use of complex instruments that extend the peri-personal workspace. To delineate brain structures involved in learning such surgical skills, 48 medical students without surgical experience were randomly assigned to five training sessions on a virtual-reality endoscopy simulator or to a non-training group. Brain activity was probed with functional MRI while participants performed endoscopic tasks. Repeated task performance in the scanner was sufficient to enhance task-related activity in left ventral premotor cortex (PMv) and the anterior Intraparietal Sulcus (aIPS). Simulator training induced additional increases in task-related activation in right PMv and aIPS and reduced effective connectivity from left to right PMv. Skill improvement after training scaled with stronger task-related activation of the lateral left primary motor hand area (M1-HAND). The results suggest that a bilateral fronto-parietal grasping network and left M1-HAND are engaged in bimanual learning of tool-based manipulations in an extended peri-personal space.
AB - Endoscopic surgery requires skilled bimanual use of complex instruments that extend the peri-personal workspace. To delineate brain structures involved in learning such surgical skills, 48 medical students without surgical experience were randomly assigned to five training sessions on a virtual-reality endoscopy simulator or to a non-training group. Brain activity was probed with functional MRI while participants performed endoscopic tasks. Repeated task performance in the scanner was sufficient to enhance task-related activity in left ventral premotor cortex (PMv) and the anterior Intraparietal Sulcus (aIPS). Simulator training induced additional increases in task-related activation in right PMv and aIPS and reduced effective connectivity from left to right PMv. Skill improvement after training scaled with stronger task-related activation of the lateral left primary motor hand area (M1-HAND). The results suggest that a bilateral fronto-parietal grasping network and left M1-HAND are engaged in bimanual learning of tool-based manipulations in an extended peri-personal space.
KW - Bimanual skill learning
KW - Endoscopic surgery
KW - Fronto-parietal grasping network
UR - http://www.scopus.com/inward/record.url?scp=85059761969&partnerID=8YFLogxK
U2 - 10.1016/j.neuroimage.2018.12.030
DO - 10.1016/j.neuroimage.2018.12.030
M3 - Journal article
C2 - 30583066
SN - 1053-8119
VL - 189
SP - 32
EP - 44
JO - NeuroImage
JF - NeuroImage
ER -