TY - JOUR
T1 - Genotyping to prevent Rh disease
T2 - has the time come?
AU - van der Schoot, C Ellen
AU - de Haas, Masja
AU - Clausen, Frederik Banch
PY - 2017/11
Y1 - 2017/11
N2 - PURPOSE OF REVIEW: In this review, we analyzed the current literature on noninvasive fetal RHD typing to answer the question whether the administration of RhIg to prevent D-alloimmunization during pregnancy can be safely guided by fetal RHD typing.RECENT FINDINGS: Recently the first centers that implemented large-scale nationwide fetal RHD typing in the second trimester for targeted RhIg administration have published their studies evaluating the diagnostic accuracy of their screening programs. These data show that fetal RHD typing in a routine setting is, at least in a population of European descent, accurate enough to guide both antenatal and postnatal immunoprophylaxis.SUMMARY: Depending on the ethnic background and the organization of pregnancy care the decisions regarding RhIg can be safely and cost-effectively based on fetal RHD typing by a duplex real-time PCR. As a result, the unnecessary administration of 40% of antenatal RhIg can be prevented, and cord blood serology can be omitted.
AB - PURPOSE OF REVIEW: In this review, we analyzed the current literature on noninvasive fetal RHD typing to answer the question whether the administration of RhIg to prevent D-alloimmunization during pregnancy can be safely guided by fetal RHD typing.RECENT FINDINGS: Recently the first centers that implemented large-scale nationwide fetal RHD typing in the second trimester for targeted RhIg administration have published their studies evaluating the diagnostic accuracy of their screening programs. These data show that fetal RHD typing in a routine setting is, at least in a population of European descent, accurate enough to guide both antenatal and postnatal immunoprophylaxis.SUMMARY: Depending on the ethnic background and the organization of pregnancy care the decisions regarding RhIg can be safely and cost-effectively based on fetal RHD typing by a duplex real-time PCR. As a result, the unnecessary administration of 40% of antenatal RhIg can be prevented, and cord blood serology can be omitted.
KW - Blood Group Incompatibility/prevention & control
KW - Erythroblastosis, Fetal/prevention & control
KW - Genotyping Techniques/methods
KW - Humans
KW - Rh-Hr Blood-Group System/genetics
U2 - 10.1097/MOH.0000000000000379
DO - 10.1097/MOH.0000000000000379
M3 - Review
C2 - 28937404
SN - 1065-6251
VL - 24
SP - 544
EP - 550
JO - Current Opinion in Hematology
JF - Current Opinion in Hematology
IS - 6
ER -