Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Low-Frequency and Rare-Coding Variation Contributes to Multiple Sclerosis Risk

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Human Disease Variation in the Light of Population Genomics

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  3. Low-Frequency and Rare-Coding Variation Contributes to Multiple Sclerosis Risk

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Drug-Driven Phenotypic Convergence Supports Rational Treatment Strategies of Chronic Infections

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Reappraisal is an effective emotion regulation strategy in children with Tourette syndrome and ADHD

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Autism spectrum disorder and attention deficit hyperactivity disorder have a similar burden of rare protein-truncating variants

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Clinical association to FKBP5 rs1360780 in patients with depression

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Jordan W Smoller
  • Julie Hagstrøm (Medlem af forfattergruppering)
  • Cross-Disorder Group of the Psychiatric Genomics Consortium
  • Thomas Mears Werge (Medlem af forfattergruppering)
Vis graf over relationer

Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting substantial pleiotropy of contributing loci. However, the nature and mechanisms of these pleiotropic effects remain unclear. We performed analyses of 232,964 cases and 494,162 controls from genome-wide studies of anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, and Tourette syndrome. Genetic correlation analyses revealed a meaningful structure within the eight disorders, identifying three groups of inter-related disorders. Meta-analysis across these eight disorders detected 109 loci associated with at least two psychiatric disorders, including 23 loci with pleiotropic effects on four or more disorders and 11 loci with antagonistic effects on multiple disorders. The pleiotropic loci are located within genes that show heightened expression in the brain throughout the lifespan, beginning prenatally in the second trimester, and play prominent roles in neurodevelopmental processes. These findings have important implications for psychiatric nosology, drug development, and risk prediction.

OriginalsprogEngelsk
TidsskriftCell
Vol/bind179
Udgave nummer7
Sider (fra-til)1469-1482
ISSN0092-8674
DOI
StatusUdgivet - 12 dec. 2019

Bibliografisk note

Copyright © 2019 Elsevier Inc. All rights reserved.

ID: 58646516