Genomic Epidemiology of a Major Mycobacterium tuberculosis Outbreak: Retrospective Cohort Study in a Low-Incidence Setting Using Sparse Time-Series Sampling

Dorte Bek Folkvardsen, Anders Norman, Åse Bengård Andersen, Erik Michael Rasmussen, Lars Jelsbak, Troels Lillebaek

    23 Citationer (Scopus)

    Abstract

    Since 1992, Denmark has documented the largest outbreak of tuberculosis in Scandinavia ascribed to a single genotype, termed C2/1112-15. As of spring 2017, the International Reference Laboratory of Mycobacteriology in Copenhagen has collected and identified isolates from more than a thousand cases belonging to this outbreak via routine mycobacterial interspersed repetitive units-variable number of tandem repeats typing. Here, we present a retrospective analysis of the C2/1112-15 dataset, based on whole-genome data from a sparse time series consisting of 5 randomly selected isolates from 23 years of sampling. Even if these data are derived from only 12% of the collected isolates, we have been able to extract important key information, such as mutation rate and conserved single-nucleotide polymorphisms to identify discrete transmission chains, as well as the possible historical origins of the outbreak.

    OriginalsprogEngelsk
    TidsskriftThe Journal of infectious diseases
    Vol/bind216
    Udgave nummer3
    Sider (fra-til)366-374
    Antal sider9
    ISSN0022-1899
    DOI
    StatusUdgivet - 1 aug. 2017

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