Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. FUT2-ABO epistasis increases the risk of early childhood asthma and Streptococcus pneumoniae respiratory illnesses

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. An atlas of O-linked glycosylation on peptide hormones reveals diverse biological roles

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Functional hypoxia drives neuroplasticity and neurogenesis via brain erythropoietin

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Genome-wide association study of circulating levels of glucagon during an oral glucose tolerance test

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Genome-Wide Association Analysis of Pancreatic Beta Cell Glucose Sensitivity

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Female cigarette smoking and successful fertility treatment: a Danish cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. FUT2-ABO epistasis increases the risk of early childhood asthma and Streptococcus pneumoniae respiratory illnesses

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. The effect of diabetes and the common diabetogenic TBC1D4 p.Arg684Ter variant on cardiovascular risk in Inuit in Greenland

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Anne E Justice
  • Thomas W Winkler
  • Mary F Feitosa
  • Misa Graff
  • Virginia A Fisher
  • Kristin L Young
  • Llilda Barata
  • Xuan Deng
  • Jacek Czajkowski
  • David Hadley
  • Julius S Ngwa
  • Tarunveer S Ahluwalia
  • Audrey Y Chu
  • Nancy L Heard-Costa
  • Elise Lim
  • Jeremiah Perez
  • John D Eicher
  • Zoltán Kutalik
  • Luting Xue
  • Anubha Mahajan
  • Frida Renström
  • Joseph M W Wu
  • Qibin Qi
  • Shafqat Ahmad
  • Tamuno Alfred
  • Najaf Amin
  • Lawrence F Bielak
  • Amélie Bonnefond
  • Jennifer L Bragg-Gresham
  • Gemma Cadby
  • Martina Chittani
  • Scott Coggeshall
  • Tanguy Corre
  • Nese Direk
  • Joel Eriksson
  • Krista Fischer
  • Mathias Gorski
  • Marie Neergaard Harder
  • Momoko Horikoshi
  • Tao Huang
  • Jennifer E Huffman
  • Anne U Jackson
  • Johanne Marie Justesen
  • Stavroula Kanoni
  • Leena Kinnunen
  • Marcus E Kleber
  • Pirjo Komulainen
  • Meena Kumari
  • Unhee Lim
  • Jian'an Luan
  • Leo-Pekka Lyytikäinen
  • Massimo Mangino
  • Ani Manichaikul
  • Jonathan Marten
  • Rita P S Middelberg
  • Martina Müller-Nurasyid
  • Pau Navarro
  • Louis Pérusse
  • Natalia Pervjakova
  • Cinzia Sarti
  • Albert Vernon Smith
  • Jennifer A Smith
  • Alena Stančáková
  • Rona J Strawbridge
  • Heather M Stringham
  • Yun Ju Sung
  • Toshiko Tanaka
  • Alexander Teumer
  • Stella Trompet
  • Sander W van der Laan
  • Peter J van der Most
  • Jana V van Vliet-Ostaptchouk
  • Sailaja L Vedantam
  • Niek Verweij
  • Jacqueline M Vink
  • Veronique Vitart
  • Ying Wu
  • Loic Yengo
  • Weihua Zhang
  • Jing Hua Zhao
  • Martina E Zimmermann
  • Niha Zubair
  • Goncalo R Abecasis
  • Linda S Adair
  • Saima Afaq
  • Uzma Afzal
  • Stephan J L Bakker
  • Traci M Bartz
  • John Beilby
  • Richard N Bergman
  • Sven Bergmann
  • Reiner Biffar
  • John Blangero
  • Eric Boerwinkle
  • Lori L Bonnycastle
  • Erwin P Bottinger
  • Daniele Braga
  • Brendan M Buckley
  • Steve Buyske
  • Harry Campbell
  • John C Chambers
  • Francis S Collins
  • Joanne E Curran
  • Gert Jan de Borst
  • Anton J M De Craen
  • Eco J.C. De Geus
  • George V Dedoussis
  • Graciela E Delgado
  • Hester M den Ruijter
  • Gudny Eiriksdottir
  • Anna L Eriksson
  • Tõnu Esko
  • Jessica D Faul
  • Ian Ford
  • Terrence Forrester
  • Karl Gertow
  • Bruna Gigante
  • Nicola Glorioso
  • Jian Gong
  • Harald Grallert
  • Tanja B Grammer
  • Niels Grarup
  • Saskia Haitjema
  • Göran Hallmans
  • Anders Hamsten
  • Torben Hansen
  • Tamara B Harris
  • Catharina A Hartman
  • Maija Hassinen
  • Nicholas D Hastie
  • Andrew C Heath
  • Dena Hernandez
  • Lucia A Hindorff
  • Lynne J Hocking
  • Mette Hollensted
  • Oddgeir L Holmen
  • Georg Homuth
  • Jouke Jan Hottenga
  • Jie Huang
  • Joseph Hung
  • Nina Hutri-Kähönen
  • Erik Ingelsson
  • Alan L James
  • John-Olov Jansson
  • Marjo-Riitta Jarvelin
  • Min A Jhun
  • Marit E Jørgensen
  • Markus Juonala
  • Mika Kähönen
  • Magnus Karlsson
  • Heikki A Koistinen
  • Ivana Kolcic
  • Genovefa D Kolovou
  • Charles Kooperberg
  • Bernhard K Krämer
  • Johanna Kuusisto
  • Kirsti Kvaløy
  • Timo A Lakka
  • Claudia Langenberg
  • Lenore J Launer
  • Karin Leander
  • Nanette R Lee
  • Lars Lind
  • Cecilia M Lindgren
  • Allan Linneberg
  • Stéphane Lobbens
  • Marie Loh
  • Mattias Lorentzon
  • Robert Luben
  • Gitta Lubke
  • Anja Ludolph-Donislawski
  • Sara Lupoli
  • Pamela A F Madden
  • Reija Männikkö
  • Pedro Marques-Vidal
  • Nicholas G Martin
  • Colin A McKenzie
  • Barbara McKnight
  • Dan Mellström
  • Cristina Menni
  • Grant W Montgomery
  • Aw Bill Musk
  • Narisu Narisu
  • Matthias Nauck
  • Ilja M Nolte
  • Albertine J Oldehinkel
  • Matthias Olden
  • Ken K Ong
  • Sandosh Padmanabhan
  • Patricia A Peyser
  • Charlotta Pisinger
  • David J Porteous
  • Olli T Raitakari
  • Tuomo Rankinen
  • D C Rao
  • Laura J Rasmussen-Torvik
  • Rajesh Rawal
  • Treva K Rice
  • Paul M Ridker
  • Lynda M Rose
  • Stephanie A Bien
  • Igor Rudan
  • Serena Sanna
  • Mark A Sarzynski
  • Naveed Sattar
  • Kai Savonen
  • David Schlessinger
  • Salome Scholtens
  • Claudia Schurmann
  • Robert A Scott
  • Bengt Sennblad
  • Marten A Siemelink
  • Günther Silbernagel
  • P Eline Slagboom
  • Harold Snieder
  • Jan A Staessen
  • David J Stott
  • Morris A Swertz
  • Amy J Swift
  • Kent D Taylor
  • Bamidele O Tayo
  • Barbara Thorand
  • Dorothee Thuillier
  • Jaakko Tuomilehto
  • André G Uitterlinden
  • Liesbeth Vandenput
  • Marie-Claude Vohl
  • Henry Völzke
  • Judith M Vonk
  • Gérard Waeber
  • Melanie Waldenberger
  • R G J Westendorp
  • Sarah Wild
  • Gonneke Willemsen
  • Bruce H R Wolffenbuttel
  • Andrew Wong
  • Alan F Wright
  • Wei Zhao
  • M Carola Zillikens
  • Damiano Baldassarre
  • Beverley Balkau
  • Stefania Bandinelli
  • Carsten A Böger
  • Dorret I Boomsma
  • Claude Bouchard
  • Marcel Bruinenberg
  • Daniel I Chasman
  • Yii-DerIda Chen
  • Peter S Chines
  • Richard S Cooper
  • Francesco Cucca
  • Daniele Cusi
  • Ulf de Faire
  • Luigi Ferrucci
  • Paul W Franks
  • Philippe Froguel
  • Penny Gordon-Larsen
  • Hans Jörgen Grabe
  • Vilmundur Gudnason
  • Christopher A Haiman
  • Caroline Hayward
  • Kristian Hveem
  • Andrew D Johnson
  • J Wouter Jukema
  • Sharon L R Kardia
  • Mika Kivimaki
  • Jaspal S Kooner
  • Diana Kuh
  • Markku Laakso
  • Terho Lehtimäki
  • Loic Le Marchand
  • Winfried März
  • Mark I McCarthy
  • Andres Metspalu
  • Andrew P Morris
  • Claes Ohlsson
  • Lyle J Palmer
  • Gerard Pasterkamp
  • Oluf Pedersen
  • Annette Peters
  • Ulrike Peters
  • Ozren Polasek
  • Bruce M Psaty
  • Lu Qi
  • Rainer Rauramaa
  • Blair H Smith
  • Thorkild I A Sørensen
  • Konstantin Strauch
  • Henning Tiemeier
  • Elena Tremoli
  • Pim van der Harst
  • Henrik Vestergaard
  • Peter Vollenweider
  • Nicholas J Wareham
  • David R Weir
  • John B Whitfield
  • James F Wilson
  • Jessica Tyrrell
  • Timothy M Frayling
  • Inês Barroso
  • Michael Boehnke
  • Panagiotis Deloukas
  • Caroline S Fox
  • Joel N Hirschhorn
  • David J Hunter
  • Tim D Spector
  • David P Strachan
  • Cornélia M van Duijn
  • Iris M Heid
  • Karen L Mohlke
  • Jonathan Marchini
  • Ruth J F Loos
  • Tuomas O Kilpeläinen
  • Ching-Ti Liu
  • Ingrid B Borecki
  • Kari E North
  • L Adrienne Cupples
Vis graf over relationer

Few genome-wide association studies (GWAS) account for environmental exposures, like smoking, potentially impacting the overall trait variance when investigating the genetic contribution to obesity-related traits. Here, we use GWAS data from 51,080 current smokers and 190,178 nonsmokers (87% European descent) to identify loci influencing BMI and central adiposity, measured as waist circumference and waist-to-hip ratio both adjusted for BMI. We identify 23 novel genetic loci, and 9 loci with convincing evidence of gene-smoking interaction (GxSMK) on obesity-related traits. We show consistent direction of effect for all identified loci and significance for 18 novel and for 5 interaction loci in an independent study sample. These loci highlight novel biological functions, including response to oxidative stress, addictive behaviour, and regulatory functions emphasizing the importance of accounting for environment in genetic analyses. Our results suggest that tobacco smoking may alter the genetic susceptibility to overall adiposity and body fat distribution.

OriginalsprogEngelsk
TidsskriftNature Communications
Vol/bind8
Sider (fra-til)14977
ISSN2041-1723
DOI
StatusUdgivet - 26 apr. 2017

ID: 50293437