Genome-wide population-based association study of extremely overweight young adults--the GOYA study

Lavinia Paternoster, David M Evans, Ellen Aagaard Nohr, Claus Holst, Valerie Gaborieau, Paul Brennan, Anette Prior Gjesing, Niels Grarup, Daniel R Witte, Torben Jørgensen, Allan Linneberg, Torsten Lauritzen, Anelli Sandbaek, Torben Hansen, Oluf Pedersen, Katherine S Elliott, John P Kemp, Beate St Pourcain, George McMahon, Diana ZelenikaJörg Hager, Mark Lathrop, Nicholas J Timpson, George Davey Smith, Thorkild I A Sørensen

    87 Citationer (Scopus)

    Abstract

    Thirty-two common variants associated with body mass index (BMI) have been identified in genome-wide association studies, explaining ∼1.45% of BMI variation in general population cohorts. We performed a genome-wide association study in a sample of young adults enriched for extremely overweight individuals. We aimed to identify new loci associated with BMI and to ascertain whether using an extreme sampling design would identify the variants known to be associated with BMI in general populations.
    OriginalsprogEngelsk
    TidsskriftP L o S One
    Vol/bind6
    Udgave nummer9
    Sider (fra-til)e24303
    ISSN1932-6203
    DOI
    StatusUdgivet - 2011

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