Genome-wide peripheral blood leukocyte DNA methylation microarrays identified a single association with inflammatory bowel diseases

R Alan Harris; Dorottya Nagy-Szakal; Natalia Pedersen; Antone Opekun; Jiri Bronsky; Pia Munkholm; Cathrine Jespersgaard; PaalSkytt Andersen; Bela Melegh; George Ferry; Tine Jess; Richard Kellermayer

doi:10.1002/ibd.22956

Genome-wide peripheral blood leukocyte DNA methylation microarrays identified a single association with inflammatory bowel diseases

R Alan Harris, Dorottya Nagy-Szakal, Natalia Pedersen, Antone Opekun, Jiri Bronsky, Pia Munkholm, Cathrine Jespersgaard, PaalSkytt Andersen, Bela Melegh, George Ferry, Tine Jess, Richard Kellermayer

Mave-, Tarm- og Leversygdomme

67 Citationer (Scopus)

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Crohn's disease (CD) and ulcerative colitis (UC) are common forms of inflammatory bowel disease (IBD). Monozygotic (MZ) twin discordance rates and epidemiologic data implicate that environmental changes and epigenetic factors may play a pathogenic role in IBD. DNA methylation (the methylation of cytosines within CpG dinucleotides) is an epigenetic modification, which can respond to environmental influences. We investigated whether DNA methylation might be connected with IBD in peripheral blood leukocyte (PBL) DNA by utilizing genome-wide microarrays.

Originalsprog	Engelsk
Tidsskrift	Inflammatory Bowel Diseases
Vol/bind	18
Udgave nummer	12
Sider (fra-til)	2334-41
Antal sider	8
ISSN	1078-0998
DOI	https://doi.org/10.1002/ibd.22956
Status	Udgivet - 2012

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10.1002/ibd.22956

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Harris, R. A., Nagy-Szakal, D., Pedersen, N., Opekun, A., Bronsky, J., Munkholm, P., Jespersgaard, C., Andersen, P., Melegh, B., Ferry, G., Jess, T., & Kellermayer, R. (2012). Genome-wide peripheral blood leukocyte DNA methylation microarrays identified a single association with inflammatory bowel diseases. Inflammatory Bowel Diseases, 18(12), 2334-41. https://doi.org/10.1002/ibd.22956

Harris, RA, Nagy-Szakal, D, Pedersen, N, Opekun, A, Bronsky, J, Munkholm, P, Jespersgaard, C, Andersen, P, Melegh, B, Ferry, G, Jess, T & Kellermayer, R 2012, 'Genome-wide peripheral blood leukocyte DNA methylation microarrays identified a single association with inflammatory bowel diseases', Inflammatory Bowel Diseases, bind 18, nr. 12, s. 2334-41. https://doi.org/10.1002/ibd.22956

@article{6be4651ea2564f27847c16e7e7419bce,

title = "Genome-wide peripheral blood leukocyte DNA methylation microarrays identified a single association with inflammatory bowel diseases",

abstract = "Crohn's disease (CD) and ulcerative colitis (UC) are common forms of inflammatory bowel disease (IBD). Monozygotic (MZ) twin discordance rates and epidemiologic data implicate that environmental changes and epigenetic factors may play a pathogenic role in IBD. DNA methylation (the methylation of cytosines within CpG dinucleotides) is an epigenetic modification, which can respond to environmental influences. We investigated whether DNA methylation might be connected with IBD in peripheral blood leukocyte (PBL) DNA by utilizing genome-wide microarrays.",

author = "Harris, {R Alan} and Dorottya Nagy-Szakal and Natalia Pedersen and Antone Opekun and Jiri Bronsky and Pia Munkholm and Cathrine Jespersgaard and PaalSkytt Andersen and Bela Melegh and George Ferry and Tine Jess and Richard Kellermayer",

note = "Copyright {\textcopyright} 2012 Crohn's & Colitis Foundation of America, Inc.",

year = "2012",

doi = "10.1002/ibd.22956",

language = "English",

volume = "18",

pages = "2334--41",

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TY - JOUR

T1 - Genome-wide peripheral blood leukocyte DNA methylation microarrays identified a single association with inflammatory bowel diseases

AU - Harris, R Alan

AU - Nagy-Szakal, Dorottya

AU - Pedersen, Natalia

AU - Opekun, Antone

AU - Bronsky, Jiri

AU - Munkholm, Pia

AU - Jespersgaard, Cathrine

AU - Andersen, PaalSkytt

AU - Melegh, Bela

AU - Ferry, George

AU - Jess, Tine

AU - Kellermayer, Richard

PY - 2012

Y1 - 2012

N2 - Crohn's disease (CD) and ulcerative colitis (UC) are common forms of inflammatory bowel disease (IBD). Monozygotic (MZ) twin discordance rates and epidemiologic data implicate that environmental changes and epigenetic factors may play a pathogenic role in IBD. DNA methylation (the methylation of cytosines within CpG dinucleotides) is an epigenetic modification, which can respond to environmental influences. We investigated whether DNA methylation might be connected with IBD in peripheral blood leukocyte (PBL) DNA by utilizing genome-wide microarrays.

AB - Crohn's disease (CD) and ulcerative colitis (UC) are common forms of inflammatory bowel disease (IBD). Monozygotic (MZ) twin discordance rates and epidemiologic data implicate that environmental changes and epigenetic factors may play a pathogenic role in IBD. DNA methylation (the methylation of cytosines within CpG dinucleotides) is an epigenetic modification, which can respond to environmental influences. We investigated whether DNA methylation might be connected with IBD in peripheral blood leukocyte (PBL) DNA by utilizing genome-wide microarrays.

U2 - 10.1002/ibd.22956

DO - 10.1002/ibd.22956

M3 - Journal article

C2 - 22467598

VL - 18

SP - 2334

EP - 2341

JO - Inflammatory Bowel Diseases

JF - Inflammatory Bowel Diseases

SN - 1078-0998

IS - 12

ER -

Genome-wide peripheral blood leukocyte DNA methylation microarrays identified a single association with inflammatory bowel diseases

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