Genome-wide peripheral blood leukocyte DNA methylation microarrays identified a single association with inflammatory bowel diseases

R Alan Harris, Dorottya Nagy-Szakal, Natalia Pedersen, Antone Opekun, Jiri Bronsky, Pia Munkholm, Cathrine Jespersgaard, PaalSkytt Andersen, Bela Melegh, George Ferry, Tine Jess, Richard Kellermayer

69 Citationer (Scopus)

Abstract

Crohn's disease (CD) and ulcerative colitis (UC) are common forms of inflammatory bowel disease (IBD). Monozygotic (MZ) twin discordance rates and epidemiologic data implicate that environmental changes and epigenetic factors may play a pathogenic role in IBD. DNA methylation (the methylation of cytosines within CpG dinucleotides) is an epigenetic modification, which can respond to environmental influences. We investigated whether DNA methylation might be connected with IBD in peripheral blood leukocyte (PBL) DNA by utilizing genome-wide microarrays.
OriginalsprogEngelsk
TidsskriftInflammatory Bowel Diseases
Vol/bind18
Udgave nummer12
Sider (fra-til)2334-41
Antal sider8
ISSN1078-0998
DOI
StatusUdgivet - 2012

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