Genome-wide Linkage Disequilibrium Linkage Analysis (LDLA) of Body Fat Traits in an F2 Porcine Model for Human Obesity

Sameer Dinkar Pant; Peter Karlskov-Mortensen; Susanna Cirera Salicio; Lisette Kogelman; Mette Juul Jacobsen; Camilla Vibeke Sichlau Bruun; Claus Bøttcher Jørgensen; T.H.E. Meuwissen; Haja Kadarmideen; Merete Fredholm

Genome-wide Linkage Disequilibrium Linkage Analysis (LDLA) of Body Fat Traits in an F2 Porcine Model for Human Obesity

Sameer Dinkar Pant, Peter Karlskov-Mortensen, Susanna Cirera Salicio, Lisette Kogelman, Mette Juul Jacobsen, Camilla Vibeke Sichlau Bruun, Claus Bøttcher Jørgensen, T.H.E. Meuwissen, Haja Kadarmideen, Merete Fredholm

Abstract

ABSTRACT: Purebred Duroc and Yorkshire sows were
crossed with Göttingen minipig boars to obtain two separate
F2 intercross resource populations (n=287 and 279
respectively). Several obesity, metabolic and slaughter
measurements were recorded from birth to slaughter (220 ±
45 days). In addition, body composition was determined at
about two months of age (64 ± 11 days) via dual-energy xray
absorptiometry (DXA) scanning. All pigs were
genotyped using Illumina Porcine 60k SNP Beadchip and a
combined LDLA approach was used to perform genomewide
linkage and association analysis for body fat traits.
Subsequently bioinformatic analysis was performed to
identify genes in close proximity of chromosomal positions
where statistically significant QTLs were identified. Several
important genes previously linked to obesity (e.g. BBS4,
CHRNA2, DLK1), along with other novel genes were
identified, that together provide novel insights that may
further the current understanding of the molecular
mechanisms underlying human obesity.

Originalsprog	Engelsk
Publikationsdato	2014
Antal sider	4
Status	Udgivet - 2014
Udgivet eksternt	Ja
Begivenhed	10th World Congress of Genetics Applied to Livestock Production: WCGALP - Vancouver, Canada Varighed: 16 aug. 2014 → 23 aug. 2014

Konference

Konference	10th World Congress of Genetics Applied to Livestock Production
Land/Område	Canada
By	Vancouver
Periode	16/08/2014 → 23/08/2014

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https://asas.org/docs/default-source/wcgalp-posters/595_paper_8938_manuscript_319_0.pdf?sfvrsn=2

Citationsformater

Pant, S. D., Karlskov-Mortensen, P., Cirera Salicio, S., Kogelman, L., Jacobsen, M. J., Bruun, C. V. S., Jørgensen, C. B., Meuwissen, T. H. E., Kadarmideen, H., & Fredholm, M. (2014). Genome-wide Linkage Disequilibrium Linkage Analysis (LDLA) of Body Fat Traits in an F2 Porcine Model for Human Obesity. Poster session præsenteret på 10th World Congress of Genetics Applied to Livestock Production, Vancouver, Canada. https://asas.org/docs/default-source/wcgalp-posters/595_paper_8938_manuscript_319_0.pdf?sfvrsn=2

Genome-wide Linkage Disequilibrium Linkage Analysis (LDLA) of Body Fat Traits in an F2 Porcine Model for Human Obesity. / Pant, Sameer Dinkar; Karlskov-Mortensen, Peter; Cirera Salicio, Susanna et al.
2014. Poster session præsenteret på 10th World Congress of Genetics Applied to Livestock Production, Vancouver, Canada.

Publikation: Konferencebidrag › Poster › Forskning › peer review

Pant, SD, Karlskov-Mortensen, P, Cirera Salicio, S, Kogelman, L, Jacobsen, MJ, Bruun, CVS, Jørgensen, CB, Meuwissen, THE, Kadarmideen, H & Fredholm, M 2014, 'Genome-wide Linkage Disequilibrium Linkage Analysis (LDLA) of Body Fat Traits in an F2 Porcine Model for Human Obesity', 10th World Congress of Genetics Applied to Livestock Production, Vancouver, Canada, 16/08/2014 - 23/08/2014. <https://asas.org/docs/default-source/wcgalp-posters/595_paper_8938_manuscript_319_0.pdf?sfvrsn=2>

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title = "Genome-wide Linkage Disequilibrium Linkage Analysis (LDLA) of Body Fat Traits in an F2 Porcine Model for Human Obesity",

abstract = "ABSTRACT: Purebred Duroc and Yorkshire sows werecrossed with G{\"o}ttingen minipig boars to obtain two separateF2 intercross resource populations (n=287 and 279respectively). Several obesity, metabolic and slaughtermeasurements were recorded from birth to slaughter (220 ±45 days). In addition, body composition was determined atabout two months of age (64 ± 11 days) via dual-energy xrayabsorptiometry (DXA) scanning. All pigs weregenotyped using Illumina Porcine 60k SNP Beadchip and acombined LDLA approach was used to perform genomewidelinkage and association analysis for body fat traits.Subsequently bioinformatic analysis was performed toidentify genes in close proximity of chromosomal positionswhere statistically significant QTLs were identified. Severalimportant genes previously linked to obesity (e.g. BBS4,CHRNA2, DLK1), along with other novel genes wereidentified, that together provide novel insights that mayfurther the current understanding of the molecularmechanisms underlying human obesity.",

author = "Pant, {Sameer Dinkar} and Peter Karlskov-Mortensen and {Cirera Salicio}, Susanna and Lisette Kogelman and Jacobsen, {Mette Juul} and Bruun, {Camilla Vibeke Sichlau} and J{\o}rgensen, {Claus B{\o}ttcher} and T.H.E. Meuwissen and Haja Kadarmideen and Merete Fredholm",

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note = "10th World Congress of Genetics Applied to Livestock Production ; Conference date: 16-08-2014 Through 23-08-2014",

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TY - CONF

T1 - Genome-wide Linkage Disequilibrium Linkage Analysis (LDLA) of Body Fat Traits in an F2 Porcine Model for Human Obesity

AU - Pant, Sameer Dinkar

AU - Karlskov-Mortensen, Peter

AU - Cirera Salicio, Susanna

AU - Kogelman, Lisette

AU - Jacobsen, Mette Juul

AU - Bruun, Camilla Vibeke Sichlau

AU - Jørgensen, Claus Bøttcher

AU - Meuwissen, T.H.E.

AU - Kadarmideen, Haja

AU - Fredholm, Merete

PY - 2014

Y1 - 2014

N2 - ABSTRACT: Purebred Duroc and Yorkshire sows werecrossed with Göttingen minipig boars to obtain two separateF2 intercross resource populations (n=287 and 279respectively). Several obesity, metabolic and slaughtermeasurements were recorded from birth to slaughter (220 ±45 days). In addition, body composition was determined atabout two months of age (64 ± 11 days) via dual-energy xrayabsorptiometry (DXA) scanning. All pigs weregenotyped using Illumina Porcine 60k SNP Beadchip and acombined LDLA approach was used to perform genomewidelinkage and association analysis for body fat traits.Subsequently bioinformatic analysis was performed toidentify genes in close proximity of chromosomal positionswhere statistically significant QTLs were identified. Severalimportant genes previously linked to obesity (e.g. BBS4,CHRNA2, DLK1), along with other novel genes wereidentified, that together provide novel insights that mayfurther the current understanding of the molecularmechanisms underlying human obesity.

AB - ABSTRACT: Purebred Duroc and Yorkshire sows werecrossed with Göttingen minipig boars to obtain two separateF2 intercross resource populations (n=287 and 279respectively). Several obesity, metabolic and slaughtermeasurements were recorded from birth to slaughter (220 ±45 days). In addition, body composition was determined atabout two months of age (64 ± 11 days) via dual-energy xrayabsorptiometry (DXA) scanning. All pigs weregenotyped using Illumina Porcine 60k SNP Beadchip and acombined LDLA approach was used to perform genomewidelinkage and association analysis for body fat traits.Subsequently bioinformatic analysis was performed toidentify genes in close proximity of chromosomal positionswhere statistically significant QTLs were identified. Severalimportant genes previously linked to obesity (e.g. BBS4,CHRNA2, DLK1), along with other novel genes wereidentified, that together provide novel insights that mayfurther the current understanding of the molecularmechanisms underlying human obesity.

M3 - Poster

T2 - 10th World Congress of Genetics Applied to Livestock Production

Y2 - 16 August 2014 through 23 August 2014

ER -

Genome-wide Linkage Disequilibrium Linkage Analysis (LDLA) of Body Fat Traits in an F2 Porcine Model for Human Obesity

Abstract

Konference

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