Genome-wide identification of structural variants in genes encoding drug targets: possible implications for individualized drug therapy

Henrik Berg Rasmussen; Christina Mackeprang Dahmcke

doi:10.1097/FPC.0b013e328352c770

Genome-wide identification of structural variants in genes encoding drug targets: possible implications for individualized drug therapy

Henrik Berg Rasmussen
, Christina Mackeprang Dahmcke

7 Citationer (Scopus)

Abstract

The objective of the present study was to identify structural variants of drug target-encoding genes on a genome-wide scale. We also aimed at identifying drugs that are potentially amenable for individualization of treatments based on knowledge about structural variation in the genes encoding their targets.

Originalsprog	Engelsk
Tidsskrift	Pharmacogenetics and Genomics
Vol/bind	22
Udgave nummer	7
Sider (fra-til)	471-83
Antal sider	13
ISSN	1744-6872
DOI	https://doi.org/10.1097/FPC.0b013e328352c770
Status	Udgivet - jul. 2012

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10.1097/FPC.0b013e328352c770

Citationsformater

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title = "Genome-wide identification of structural variants in genes encoding drug targets: possible implications for individualized drug therapy",

abstract = "The objective of the present study was to identify structural variants of drug target-encoding genes on a genome-wide scale. We also aimed at identifying drugs that are potentially amenable for individualization of treatments based on knowledge about structural variation in the genes encoding their targets.",

keywords = "DNA Copy Number Variations, Databases, Factual, Genetic Variation, Genome, Human, Genomics, Humans, Pharmaceutical Preparations, Pharmacogenetics, Proteins, United States, United States Food and Drug Administration",

author = "Rasmussen, \{Henrik Berg\} and Dahmcke, \{Christina Mackeprang\}",

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AU - Rasmussen, Henrik Berg

AU - Dahmcke, Christina Mackeprang

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AB - The objective of the present study was to identify structural variants of drug target-encoding genes on a genome-wide scale. We also aimed at identifying drugs that are potentially amenable for individualization of treatments based on knowledge about structural variation in the genes encoding their targets.

KW - DNA Copy Number Variations

KW - Databases, Factual

KW - Genetic Variation

KW - Genome, Human

KW - Genomics

KW - Humans

KW - Pharmaceutical Preparations

KW - Pharmacogenetics

KW - Proteins

KW - United States

KW - United States Food and Drug Administration

U2 - 10.1097/FPC.0b013e328352c770

DO - 10.1097/FPC.0b013e328352c770

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SN - 1744-6872

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SP - 471

EP - 483

JO - Pharmacogenetics and Genomics

JF - Pharmacogenetics and Genomics

IS - 7

ER -

Genome-wide identification of structural variants in genes encoding drug targets: possible implications for individualized drug therapy

Abstract

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