Genome-wide Association Study points to novel locus for Gilles de la Tourette Syndrome

Fotis Tsetsos; Apostolia Topaloudi; Pritesh Jain; Zhiyu Yang; Dongmei Yu; Petros Kolovos; Zeynep Tumer; Renata Rizzo; Andreas Hartmann; Christel Depienne; Yulia Worbe; Kirsten R Müller-Vahl; Danielle C Cath; Dorret I Boomsma; Tomasz Wolanczyk; Cezary Zekanowski; Csaba Barta; Zsofia Nemoda; Zsanett Tarnok; Shanmukha S Padmanabhuni; Joseph D Buxbaum; Dorothy Grice; Jeffrey Glennon; Hreinn Stefansson; Bastian Hengerer; Evangelia Yannaki; John A Stamatoyannopoulos; Noa Benaroya-Milshtein; Francesco Cardona; Tammy Hedderly; Isobel Heyman; Chaim Huyser; Pablo Mir; Astrid Morer; Norbert Mueller; Alexander Munchau; Kerstin J Plessen; Cesare Porcelli; Veit Roessner; Susanne Walitza; Anette Schrag; Davide Martino; Jay A Tischfield; Gary A Heiman; A Jeremy Willsey; Andrea Dietrich; Lea K Davis; James J Crowley; Carol A Mathews; Jeremiah M Scharf; PGC TS Working Group

doi:10.1016/j.biopsych.2023.01.023

Genome-wide Association Study points to novel locus for Gilles de la Tourette Syndrome

Fotis Tsetsos, Apostolia Topaloudi, Pritesh Jain, Zhiyu Yang, Dongmei Yu, Petros Kolovos, Zeynep Tumer, Renata Rizzo, Andreas Hartmann, Christel Depienne, Yulia Worbe, Kirsten R Müller-Vahl, Danielle C Cath, Dorret I Boomsma, Tomasz Wolanczyk, Cezary Zekanowski, Csaba Barta, Zsofia Nemoda, Zsanett Tarnok, Shanmukha S PadmanabhuniJoseph D Buxbaum, Dorothy Grice, Jeffrey Glennon, Hreinn Stefansson, Bastian Hengerer, Evangelia Yannaki, John A Stamatoyannopoulos, Noa Benaroya-Milshtein, Francesco Cardona, Tammy Hedderly, Isobel Heyman, Chaim Huyser, Pablo Mir, Astrid Morer, Norbert Mueller, Alexander Munchau, Kerstin J Plessen, Cesare Porcelli, Veit Roessner, Susanne Walitza, Anette Schrag, Davide Martino, Jay A Tischfield, Gary A Heiman, A Jeremy Willsey, Andrea Dietrich, Lea K Davis, James J Crowley, Carol A Mathews, Jeremiah M Scharf, PGC TS Working Group

Abstrakt

BACKGROUND: Tourette Syndrome (TS) is a childhood-onset neurodevelopmental disorder of complex genetic architecture, characterized by multiple motor tics and at least one vocal tic persisting for more than one year.

METHODS: We performed a genome-wide meta-analysis integrating a novel TS cohort with previously published data, resulting in a sample size of 6,133 TS individuals and 13,565 ancestry-matched controls.

RESULTS: We identified a genome-wide significant locus on chromosome 5q15. Integration of eQTL, Hi-C and GWAS data implicated the NR2F1 gene and associated lncRNAs within the 5q15 locus. Heritability partitioning identified statistically significant enrichment in brain tissue histone marks, while polygenic risk scoring on brain volume data identified statistically significant associations with right and left thalamus volumes and right putamen volume.

CONCLUSIONS: Our work presents novel insights in the neurobiology of TS opening up new directions for future studies.

Originalsprog	Engelsk
Tidsskrift	Biological Psychiatry
ISSN	0006-3223
DOI	https://doi.org/10.1016/j.biopsych.2023.01.023
Status	E-pub ahead of print - 2 feb. 2023

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10.1016/j.biopsych.2023.01.023

Citationsformater

Tsetsos, F., Topaloudi, A., Jain, P., Yang, Z., Yu, D., Kolovos, P., Tumer, Z., Rizzo, R., Hartmann, A., Depienne, C., Worbe, Y., Müller-Vahl, K. R., Cath, D. C., Boomsma, D. I., Wolanczyk, T., Zekanowski, C., Barta, C., Nemoda, Z., Tarnok, Z., ... PGC TS Working Group (2023). Genome-wide Association Study points to novel locus for Gilles de la Tourette Syndrome. Biological Psychiatry. https://doi.org/10.1016/j.biopsych.2023.01.023

Tsetsos, F, Topaloudi, A, Jain, P, Yang, Z, Yu, D, Kolovos, P, Tumer, Z, Rizzo, R, Hartmann, A, Depienne, C, Worbe, Y, Müller-Vahl, KR, Cath, DC, Boomsma, DI, Wolanczyk, T, Zekanowski, C, Barta, C, Nemoda, Z, Tarnok, Z, Padmanabhuni, SS, Buxbaum, JD, Grice, D, Glennon, J, Stefansson, H, Hengerer, B, Yannaki, E, Stamatoyannopoulos, JA, Benaroya-Milshtein, N, Cardona, F, Hedderly, T, Heyman, I, Huyser, C, Mir, P, Morer, A, Mueller, N, Munchau, A, Plessen, KJ, Porcelli, C, Roessner, V, Walitza, S, Schrag, A, Martino, D, Tischfield, JA, Heiman, GA, Willsey, AJ, Dietrich, A, Davis, LK, Crowley, JJ, Mathews, CA, Scharf, JM & PGC TS Working Group 2023, 'Genome-wide Association Study points to novel locus for Gilles de la Tourette Syndrome', Biological Psychiatry. https://doi.org/10.1016/j.biopsych.2023.01.023

@article{3a41d8993dd8425e920a651d209d6ec6,

title = "Genome-wide Association Study points to novel locus for Gilles de la Tourette Syndrome",

abstract = "BACKGROUND: Tourette Syndrome (TS) is a childhood-onset neurodevelopmental disorder of complex genetic architecture, characterized by multiple motor tics and at least one vocal tic persisting for more than one year.METHODS: We performed a genome-wide meta-analysis integrating a novel TS cohort with previously published data, resulting in a sample size of 6,133 TS individuals and 13,565 ancestry-matched controls.RESULTS: We identified a genome-wide significant locus on chromosome 5q15. Integration of eQTL, Hi-C and GWAS data implicated the NR2F1 gene and associated lncRNAs within the 5q15 locus. Heritability partitioning identified statistically significant enrichment in brain tissue histone marks, while polygenic risk scoring on brain volume data identified statistically significant associations with right and left thalamus volumes and right putamen volume.CONCLUSIONS: Our work presents novel insights in the neurobiology of TS opening up new directions for future studies.",

author = "Fotis Tsetsos and Apostolia Topaloudi and Pritesh Jain and Zhiyu Yang and Dongmei Yu and Petros Kolovos and Zeynep Tumer and Renata Rizzo and Andreas Hartmann and Christel Depienne and Yulia Worbe and M{\"u}ller-Vahl, {Kirsten R} and Cath, {Danielle C} and Boomsma, {Dorret I} and Tomasz Wolanczyk and Cezary Zekanowski and Csaba Barta and Zsofia Nemoda and Zsanett Tarnok and Padmanabhuni, {Shanmukha S} and Buxbaum, {Joseph D} and Dorothy Grice and Jeffrey Glennon and Hreinn Stefansson and Bastian Hengerer and Evangelia Yannaki and Stamatoyannopoulos, {John A} and Noa Benaroya-Milshtein and Francesco Cardona and Tammy Hedderly and Isobel Heyman and Chaim Huyser and Pablo Mir and Astrid Morer and Norbert Mueller and Alexander Munchau and Plessen, {Kerstin J} and Cesare Porcelli and Veit Roessner and Susanne Walitza and Anette Schrag and Davide Martino and Tischfield, {Jay A} and Heiman, {Gary A} and Willsey, {A Jeremy} and Andrea Dietrich and Davis, {Lea K} and Crowley, {James J} and Mathews, {Carol A} and Scharf, {Jeremiah M} and {PGC TS Working Group}",

year = "2023",

month = feb,

day = "2",

doi = "10.1016/j.biopsych.2023.01.023",

language = "English",

journal = "Biological Psychiatry",

issn = "0006-3223",

publisher = "Elsevier Inc",

}

TY - JOUR

T1 - Genome-wide Association Study points to novel locus for Gilles de la Tourette Syndrome

AU - Tsetsos, Fotis

AU - Topaloudi, Apostolia

AU - Jain, Pritesh

AU - Yang, Zhiyu

AU - Yu, Dongmei

AU - Kolovos, Petros

AU - Tumer, Zeynep

AU - Rizzo, Renata

AU - Hartmann, Andreas

AU - Depienne, Christel

AU - Worbe, Yulia

AU - Müller-Vahl, Kirsten R

AU - Cath, Danielle C

AU - Boomsma, Dorret I

AU - Wolanczyk, Tomasz

AU - Zekanowski, Cezary

AU - Barta, Csaba

AU - Nemoda, Zsofia

AU - Tarnok, Zsanett

AU - Padmanabhuni, Shanmukha S

AU - Buxbaum, Joseph D

AU - Grice, Dorothy

AU - Glennon, Jeffrey

AU - Stefansson, Hreinn

AU - Hengerer, Bastian

AU - Yannaki, Evangelia

AU - Stamatoyannopoulos, John A

AU - Benaroya-Milshtein, Noa

AU - Cardona, Francesco

AU - Hedderly, Tammy

AU - Heyman, Isobel

AU - Huyser, Chaim

AU - Mir, Pablo

AU - Morer, Astrid

AU - Mueller, Norbert

AU - Munchau, Alexander

AU - Plessen, Kerstin J

AU - Porcelli, Cesare

AU - Roessner, Veit

AU - Walitza, Susanne

AU - Schrag, Anette

AU - Martino, Davide

AU - Tischfield, Jay A

AU - Heiman, Gary A

AU - Willsey, A Jeremy

AU - Dietrich, Andrea

AU - Davis, Lea K

AU - Crowley, James J

AU - Mathews, Carol A

AU - Scharf, Jeremiah M

AU - PGC TS Working Group

PY - 2023/2/2

Y1 - 2023/2/2

N2 - BACKGROUND: Tourette Syndrome (TS) is a childhood-onset neurodevelopmental disorder of complex genetic architecture, characterized by multiple motor tics and at least one vocal tic persisting for more than one year.METHODS: We performed a genome-wide meta-analysis integrating a novel TS cohort with previously published data, resulting in a sample size of 6,133 TS individuals and 13,565 ancestry-matched controls.RESULTS: We identified a genome-wide significant locus on chromosome 5q15. Integration of eQTL, Hi-C and GWAS data implicated the NR2F1 gene and associated lncRNAs within the 5q15 locus. Heritability partitioning identified statistically significant enrichment in brain tissue histone marks, while polygenic risk scoring on brain volume data identified statistically significant associations with right and left thalamus volumes and right putamen volume.CONCLUSIONS: Our work presents novel insights in the neurobiology of TS opening up new directions for future studies.

AB - BACKGROUND: Tourette Syndrome (TS) is a childhood-onset neurodevelopmental disorder of complex genetic architecture, characterized by multiple motor tics and at least one vocal tic persisting for more than one year.METHODS: We performed a genome-wide meta-analysis integrating a novel TS cohort with previously published data, resulting in a sample size of 6,133 TS individuals and 13,565 ancestry-matched controls.RESULTS: We identified a genome-wide significant locus on chromosome 5q15. Integration of eQTL, Hi-C and GWAS data implicated the NR2F1 gene and associated lncRNAs within the 5q15 locus. Heritability partitioning identified statistically significant enrichment in brain tissue histone marks, while polygenic risk scoring on brain volume data identified statistically significant associations with right and left thalamus volumes and right putamen volume.CONCLUSIONS: Our work presents novel insights in the neurobiology of TS opening up new directions for future studies.

U2 - 10.1016/j.biopsych.2023.01.023

DO - 10.1016/j.biopsych.2023.01.023

M3 - Journal article

C2 - 36738982

JO - Biological Psychiatry

JF - Biological Psychiatry

SN - 0006-3223

ER -

Genome-wide Association Study points to novel locus for Gilles de la Tourette Syndrome

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