Genome-Wide Association Study of Prostate Cancer-Specific Survival

Robert Szulkin; Robert Karlsson; Thomas Whitington; Markus Aly; Henrik Gronberg; Rosalind A Eeles; Douglas F Easton; Zsofia Kote-Jarai; Ali Amin Al Olama; Sara Benlloch; Kenneth Muir; Graham G Giles; Melissa C Southey; Liesel M FitzGerald; Brian E Henderson; Fredrick R Schumacher; Christopher A Haiman; Csilla Sipeky; Teuvo L J Tammela; Børge G Nordestgaard; Timothy J Key; Ruth C Travis; David E Neal; Jenny L Donovan; Freddie C Hamdy; Paul D P Pharoah; Nora Pashayan; Kay-Tee Khaw; Janet L Stanford; Stephen N Thibodeau; Shannon K McDonnell; Daniel J Schaid; Christiane Maier; Walther Vogel; Manuel Luedeke; Kathleen Herkommer; Adam S Kibel; Cezary Cybulski; Jan Lubiński; Wojciech Kluźniak; Lisa Cannon-Albright; Hermann Brenner; Volker Herrmann; Bernd Holleczek; Jong Y Park; Thomas A Sellers; Hui-Yi Lim; Chavdar Slavov; Radka P Kaneva; Vanio I Mitev; PRACTICAL Consortium

doi:10.1158/1055-9965.EPI-15-0543

Genome-Wide Association Study of Prostate Cancer-Specific Survival

Robert Szulkin
, Robert Karlsson
, Thomas Whitington
, Markus Aly
, Henrik Gronberg
, Rosalind A Eeles
, Douglas F Easton
, Zsofia Kote-Jarai
, Ali Amin Al Olama
, Sara Benlloch
, Kenneth Muir
, Graham G Giles
, Melissa C Southey
, Liesel M FitzGerald
, Brian E Henderson
, Fredrick R Schumacher
, Christopher A Haiman
, Csilla Sipeky
, Teuvo L J Tammela
, Børge G Nordestgaard

Timothy J Key, Ruth C Travis, David E Neal, Jenny L Donovan, Freddie C Hamdy, Paul D P Pharoah, Nora Pashayan, Kay-Tee Khaw, Janet L Stanford, Stephen N Thibodeau, Shannon K McDonnell, Daniel J Schaid, Christiane Maier, Walther Vogel, Manuel Luedeke, Kathleen Herkommer, Adam S Kibel, Cezary Cybulski, Jan Lubiński, Wojciech Kluźniak, Lisa Cannon-Albright, Hermann Brenner, Volker Herrmann, Bernd Holleczek, Jong Y Park, Thomas A Sellers, Hui-Yi Lim, Chavdar Slavov, Radka P Kaneva, Vanio I Mitev, PRACTICAL Consortium

Klinisk Biokemisk Afdeling

27 Citationer (Scopus)

Abstract

BACKGROUND: Unnecessary intervention and overtreatment of indolent disease are common challenges in clinical management of prostate cancer. Improved tools to distinguish lethal from indolent disease are critical.

METHODS: We performed a genome-wide survival analysis of cause-specific death in 24,023 prostate cancer patients (3,513 disease-specific deaths) from the PRACTICAL and BPC3 consortia. Top findings were assessed for replication in a Norwegian cohort (CONOR).

RESULTS: We observed no significant association between genetic variants and prostate cancer survival.

CONCLUSIONS: Common genetic variants with large impact on prostate cancer survival were not observed in this study.

IMPACT: Future studies should be designed for identification of rare variants with large effect sizes or common variants with small effect sizes. Cancer Epidemiol Biomarkers Prev; 24(11); 1796-800. ©2015 AACR.

Originalsprog	Engelsk
Tidsskrift	Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
Vol/bind	24
Udgave nummer	11
Sider (fra-til)	1796-800
Antal sider	5
ISSN	1055-9965
DOI	https://doi.org/10.1158/1055-9965.EPI-15-0543
Status	Udgivet - nov. 2015

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10.1158/1055-9965.EPI-15-0543

Citationsformater

Szulkin, R., Karlsson, R., Whitington, T., Aly, M., Gronberg, H., Eeles, R. A., Easton, D. F., Kote-Jarai, Z., Al Olama, A. A., Benlloch, S., Muir, K., Giles, G. G., Southey, M. C., FitzGerald, L. M., Henderson, B. E., Schumacher, F. R., Haiman, C. A., Sipeky, C., Tammela, T. L. J., ... PRACTICAL Consortium (2015). Genome-Wide Association Study of Prostate Cancer-Specific Survival. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 24(11), 1796-800. https://doi.org/10.1158/1055-9965.EPI-15-0543

Genome-Wide Association Study of Prostate Cancer-Specific Survival. / Szulkin, Robert; Karlsson, Robert; Whitington, Thomas et al.
I: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Bind 24, Nr. 11, 11.2015, s. 1796-800.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Szulkin, R, Karlsson, R, Whitington, T, Aly, M, Gronberg, H, Eeles, RA, Easton, DF, Kote-Jarai, Z, Al Olama, AA, Benlloch, S, Muir, K, Giles, GG, Southey, MC, FitzGerald, LM, Henderson, BE, Schumacher, FR, Haiman, CA, Sipeky, C, Tammela, TLJ, Nordestgaard, BG, Key, TJ, Travis, RC, Neal, DE, Donovan, JL, Hamdy, FC, Pharoah, PDP, Pashayan, N, Khaw, K-T, Stanford, JL, Thibodeau, SN, McDonnell, SK, Schaid, DJ, Maier, C, Vogel, W, Luedeke, M, Herkommer, K, Kibel, AS, Cybulski, C, Lubiński, J, Kluźniak, W, Cannon-Albright, L, Brenner, H, Herrmann, V, Holleczek, B, Park, JY, Sellers, TA, Lim, H-Y, Slavov, C, Kaneva, RP, Mitev, VI & PRACTICAL Consortium 2015, 'Genome-Wide Association Study of Prostate Cancer-Specific Survival', Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, bind 24, nr. 11, s. 1796-800. https://doi.org/10.1158/1055-9965.EPI-15-0543

Szulkin R, Karlsson R, Whitington T, Aly M, Gronberg H, Eeles RA et al. Genome-Wide Association Study of Prostate Cancer-Specific Survival. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2015 nov.;24(11):1796-800. doi: 10.1158/1055-9965.EPI-15-0543

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abstract = "BACKGROUND: Unnecessary intervention and overtreatment of indolent disease are common challenges in clinical management of prostate cancer. Improved tools to distinguish lethal from indolent disease are critical.METHODS: We performed a genome-wide survival analysis of cause-specific death in 24,023 prostate cancer patients (3,513 disease-specific deaths) from the PRACTICAL and BPC3 consortia. Top findings were assessed for replication in a Norwegian cohort (CONOR).RESULTS: We observed no significant association between genetic variants and prostate cancer survival.CONCLUSIONS: Common genetic variants with large impact on prostate cancer survival were not observed in this study.IMPACT: Future studies should be designed for identification of rare variants with large effect sizes or common variants with small effect sizes. Cancer Epidemiol Biomarkers Prev; 24(11); 1796-800. {\textcopyright}2015 AACR.",

author = "Robert Szulkin and Robert Karlsson and Thomas Whitington and Markus Aly and Henrik Gronberg and Eeles, \{Rosalind A\} and Easton, \{Douglas F\} and Zsofia Kote-Jarai and \{Al Olama\}, \{Ali Amin\} and Sara Benlloch and Kenneth Muir and Giles, \{Graham G\} and Southey, \{Melissa C\} and FitzGerald, \{Liesel M\} and Henderson, \{Brian E\} and Schumacher, \{Fredrick R\} and Haiman, \{Christopher A\} and Csilla Sipeky and Tammela, \{Teuvo L J\} and Nordestgaard, \{B{\o}rge G\} and Key, \{Timothy J\} and Travis, \{Ruth C\} and Neal, \{David E\} and Donovan, \{Jenny L\} and Hamdy, \{Freddie C\} and Pharoah, \{Paul D P\} and Nora Pashayan and Kay-Tee Khaw and Stanford, \{Janet L\} and Thibodeau, \{Stephen N\} and McDonnell, \{Shannon K\} and Schaid, \{Daniel J\} and Christiane Maier and Walther Vogel and Manuel Luedeke and Kathleen Herkommer and Kibel, \{Adam S\} and Cezary Cybulski and Jan Lubi{\'n}ski and Wojciech Klu{\'z}niak and Lisa Cannon-Albright and Hermann Brenner and Volker Herrmann and Bernd Holleczek and Park, \{Jong Y\} and Sellers, \{Thomas A\} and Hui-Yi Lim and Chavdar Slavov and Kaneva, \{Radka P\} and Mitev, \{Vanio I\} and \{PRACTICAL Consortium\}",

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T1 - Genome-Wide Association Study of Prostate Cancer-Specific Survival

AU - Szulkin, Robert

AU - Karlsson, Robert

AU - Whitington, Thomas

AU - Aly, Markus

AU - Gronberg, Henrik

AU - Eeles, Rosalind A

AU - Easton, Douglas F

AU - Kote-Jarai, Zsofia

AU - Al Olama, Ali Amin

AU - Benlloch, Sara

AU - Muir, Kenneth

AU - Giles, Graham G

AU - Southey, Melissa C

AU - FitzGerald, Liesel M

AU - Henderson, Brian E

AU - Schumacher, Fredrick R

AU - Haiman, Christopher A

AU - Sipeky, Csilla

AU - Tammela, Teuvo L J

AU - Nordestgaard, Børge G

AU - Key, Timothy J

AU - Travis, Ruth C

AU - Neal, David E

AU - Donovan, Jenny L

AU - Hamdy, Freddie C

AU - Pharoah, Paul D P

AU - Pashayan, Nora

AU - Khaw, Kay-Tee

AU - Stanford, Janet L

AU - Thibodeau, Stephen N

AU - McDonnell, Shannon K

AU - Schaid, Daniel J

AU - Maier, Christiane

AU - Vogel, Walther

AU - Luedeke, Manuel

AU - Herkommer, Kathleen

AU - Kibel, Adam S

AU - Cybulski, Cezary

AU - Lubiński, Jan

AU - Kluźniak, Wojciech

AU - Cannon-Albright, Lisa

AU - Brenner, Hermann

AU - Herrmann, Volker

AU - Holleczek, Bernd

AU - Park, Jong Y

AU - Sellers, Thomas A

AU - Lim, Hui-Yi

AU - Slavov, Chavdar

AU - Kaneva, Radka P

AU - Mitev, Vanio I

AU - PRACTICAL Consortium

PY - 2015/11

Y1 - 2015/11

N2 - BACKGROUND: Unnecessary intervention and overtreatment of indolent disease are common challenges in clinical management of prostate cancer. Improved tools to distinguish lethal from indolent disease are critical.METHODS: We performed a genome-wide survival analysis of cause-specific death in 24,023 prostate cancer patients (3,513 disease-specific deaths) from the PRACTICAL and BPC3 consortia. Top findings were assessed for replication in a Norwegian cohort (CONOR).RESULTS: We observed no significant association between genetic variants and prostate cancer survival.CONCLUSIONS: Common genetic variants with large impact on prostate cancer survival were not observed in this study.IMPACT: Future studies should be designed for identification of rare variants with large effect sizes or common variants with small effect sizes. Cancer Epidemiol Biomarkers Prev; 24(11); 1796-800. ©2015 AACR.

AB - BACKGROUND: Unnecessary intervention and overtreatment of indolent disease are common challenges in clinical management of prostate cancer. Improved tools to distinguish lethal from indolent disease are critical.METHODS: We performed a genome-wide survival analysis of cause-specific death in 24,023 prostate cancer patients (3,513 disease-specific deaths) from the PRACTICAL and BPC3 consortia. Top findings were assessed for replication in a Norwegian cohort (CONOR).RESULTS: We observed no significant association between genetic variants and prostate cancer survival.CONCLUSIONS: Common genetic variants with large impact on prostate cancer survival were not observed in this study.IMPACT: Future studies should be designed for identification of rare variants with large effect sizes or common variants with small effect sizes. Cancer Epidemiol Biomarkers Prev; 24(11); 1796-800. ©2015 AACR.

U2 - 10.1158/1055-9965.EPI-15-0543

DO - 10.1158/1055-9965.EPI-15-0543

M3 - Journal article

C2 - 26307654

SN - 1055-9965

VL - 24

SP - 1796

EP - 1800

JO - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

IS - 11

ER -

Genome-Wide Association Study of Prostate Cancer-Specific Survival

Abstract

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