TY - JOUR
T1 - Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia
AU - Vijayakrishnan, Jayaram
AU - Studd, James
AU - Broderick, Peter
AU - Kinnersley, Ben
AU - Holroyd, Amy
AU - Law, Philip J
AU - Kumar, Rajiv
AU - Allan, James M
AU - Harrison, Christine J
AU - Moorman, Anthony V
AU - Vora, Ajay
AU - Roman, Eve
AU - Rachakonda, Sivaramakrishna
AU - Kinsey, Sally E
AU - Sheridan, Eamonn
AU - Thompson, Pamela D
AU - Irving, Julie A
AU - Koehler, Rolf
AU - Hoffmann, Per
AU - Nöthen, Markus M
AU - Heilmann-Heimbach, Stefanie
AU - Jöckel, Karl-Heinz
AU - Easton, Douglas F
AU - Pharaoh, Paul D P
AU - Dunning, Alison M
AU - Peto, Julian
AU - Canzian, Frederico
AU - Swerdlow, Anthony
AU - Eeles, Rosalind A
AU - Kote-Jarai, ZSofia
AU - Muir, Kenneth
AU - Pashayan, Nora
AU - Greaves, Mel
AU - Zimmerman, Martin
AU - Bartram, Claus R
AU - Schrappe, Martin
AU - Stanulla, Martin
AU - Hemminki, Kari
AU - Houlston, Richard S
AU - PRACTICAL consortium (Børge Nordestgaard)
A2 - Nordestgaard, Børge G.
PY - 2018/4/9
Y1 - 2018/4/9
N2 - Genome-wide association studies (GWAS) have advanced our understanding of susceptibility to B-cell precursor acute lymphoblastic leukemia (BCP-ALL); however, much of the heritable risk remains unidentified. Here, we perform a GWAS and conduct a meta-analysis with two existing GWAS, totaling 2442 cases and 14,609 controls. We identify risk loci for BCP-ALL at 8q24.21 (rs28665337, P = 3.86 × 10-9, odds ratio (OR) = 1.34) and for ETV6-RUNX1 fusion-positive BCP-ALL at 2q22.3 (rs17481869, P = 3.20 × 10-8, OR = 2.14). Our findings provide further insights into genetic susceptibility to ALL and its biology.
AB - Genome-wide association studies (GWAS) have advanced our understanding of susceptibility to B-cell precursor acute lymphoblastic leukemia (BCP-ALL); however, much of the heritable risk remains unidentified. Here, we perform a GWAS and conduct a meta-analysis with two existing GWAS, totaling 2442 cases and 14,609 controls. We identify risk loci for BCP-ALL at 8q24.21 (rs28665337, P = 3.86 × 10-9, odds ratio (OR) = 1.34) and for ETV6-RUNX1 fusion-positive BCP-ALL at 2q22.3 (rs17481869, P = 3.20 × 10-8, OR = 2.14). Our findings provide further insights into genetic susceptibility to ALL and its biology.
KW - Child
KW - Child, Preschool
KW - Core Binding Factor Alpha 2 Subunit/genetics
KW - Female
KW - Genetic Predisposition to Disease
KW - Genome-Wide Association Study
KW - Glycosyltransferases/genetics
KW - HLA Antigens/genetics
KW - Humans
KW - Male
KW - Oncogene Proteins, Fusion/genetics
KW - Polymorphism, Single Nucleotide
KW - Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/genetics
KW - Prognosis
KW - Risk Factors
U2 - 10.1038/s41467-018-03178-z
DO - 10.1038/s41467-018-03178-z
M3 - Journal article
C2 - 29632299
SN - 2041-1722
VL - 9
SP - 1340
JO - Nature Communications
JF - Nature Communications
IS - 1
ER -