Genetiske variationers betydning for effekten af selektive serotoningenoptagelseshaemmere

Jens O Drachmann Bukh; Camilla Bock; Niels Peter Ole Mors; Lars Vedel Kessing

Genetiske variationers betydning for effekten af selektive serotoningenoptagelseshaemmere

Jens O Drachmann Bukh, Camilla Bock, Niels Peter Ole Mors, Lars Vedel Kessing

Abstract

The outcome of psychopharmacological treatment may depend on genetic polymorphisms of various neurotransmitter systems. We summarize studies of associations between genetic variations with relation to the serotonin system and response to selective serotonin reuptake inhibitors. The results are still preliminary but suggest that treatment response to antidepressant drugs is influenced by genetic factors. They also indicate that the genetic component is polygenic and highly complex and might manifest itself in interaction with other biological and environmental factors.

Bidragets oversatte titel	The influence of genetic variations on the effect of selective serotonin reuptake inhibitors
Originalsprog	Dansk
Tidsskrift	Ugeskrift for Laeger
Vol/bind	169
Udgave nummer	16
Sider (fra-til)	1439-41
Antal sider	3
ISSN	0041-5782
Status	Udgivet - 16 apr. 2007

Emneord

Antidepressive Agents, Second-Generation
Depression
Depressive Disorder
Humans
Pharmacogenetics
Polymorphism, Genetic
Receptors, Serotonin
Serotonin Plasma Membrane Transport Proteins
Serotonin Uptake Inhibitors
Treatment Outcome

Citationsformater

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title = "Genetiske variationers betydning for effekten af selektive serotoningenoptagelseshaemmere",

abstract = "The outcome of psychopharmacological treatment may depend on genetic polymorphisms of various neurotransmitter systems. We summarize studies of associations between genetic variations with relation to the serotonin system and response to selective serotonin reuptake inhibitors. The results are still preliminary but suggest that treatment response to antidepressant drugs is influenced by genetic factors. They also indicate that the genetic component is polygenic and highly complex and might manifest itself in interaction with other biological and environmental factors.",

keywords = "Antidepressive Agents, Second-Generation, Depression, Depressive Disorder, Humans, Pharmacogenetics, Polymorphism, Genetic, Receptors, Serotonin, Serotonin Plasma Membrane Transport Proteins, Serotonin Uptake Inhibitors, Treatment Outcome, English Abstract, Journal Article",

author = "Bukh, {Jens O Drachmann} and Camilla Bock and Mors, {Niels Peter Ole} and Kessing, {Lars Vedel}",

year = "2007",

month = apr,

day = "16",

language = "Dansk",

volume = "169",

pages = "1439--41",

journal = "Ugeskrift for Laeger",

issn = "0041-5782",

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number = "16",

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TY - JOUR

T1 - Genetiske variationers betydning for effekten af selektive serotoningenoptagelseshaemmere

AU - Bukh, Jens O Drachmann

AU - Bock, Camilla

AU - Mors, Niels Peter Ole

AU - Kessing, Lars Vedel

PY - 2007/4/16

Y1 - 2007/4/16

N2 - The outcome of psychopharmacological treatment may depend on genetic polymorphisms of various neurotransmitter systems. We summarize studies of associations between genetic variations with relation to the serotonin system and response to selective serotonin reuptake inhibitors. The results are still preliminary but suggest that treatment response to antidepressant drugs is influenced by genetic factors. They also indicate that the genetic component is polygenic and highly complex and might manifest itself in interaction with other biological and environmental factors.

AB - The outcome of psychopharmacological treatment may depend on genetic polymorphisms of various neurotransmitter systems. We summarize studies of associations between genetic variations with relation to the serotonin system and response to selective serotonin reuptake inhibitors. The results are still preliminary but suggest that treatment response to antidepressant drugs is influenced by genetic factors. They also indicate that the genetic component is polygenic and highly complex and might manifest itself in interaction with other biological and environmental factors.

KW - Antidepressive Agents, Second-Generation

KW - Depression

KW - Depressive Disorder

KW - Humans

KW - Pharmacogenetics

KW - Polymorphism, Genetic

KW - Receptors, Serotonin

KW - Serotonin Plasma Membrane Transport Proteins

KW - Serotonin Uptake Inhibitors

KW - Treatment Outcome

KW - English Abstract

KW - Journal Article

M3 - Tidsskriftartikel

C2 - 17484840

SN - 0041-5782

VL - 169

SP - 1439

EP - 1441

JO - Ugeskrift for Laeger

JF - Ugeskrift for Laeger

IS - 16

ER -

Genetiske variationers betydning for effekten af selektive serotoningenoptagelseshaemmere

Abstract

Emneord

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Citationsformater