Genetics of allergy and allergic sensitization: common variants, rare mutations

Klaus Bønnelykke, Rachel Sparks, Johannes Waage, Joshua D Milner

49 Citationer (Scopus)

Abstract

Our understanding of the specific genetic lesions in allergy has improved in recent years due to identification of common risk variants from genome-wide association studies (GWAS) and studies of rare, monogenic diseases. Large-scale GWAS have identified novel susceptibility loci and provided information about shared genetics between allergy, related phenotypes and autoimmunity. Studies of monogenic diseases have elucidated critical cellular pathways and protein functions responsible for allergy. These complementary approaches imply genetic mechanisms involved in Th2 immunity, T-cell differentiation, TGFβ signaling, regulatory T-cell function and skin/mucosal function as well as yet unknown mechanisms associated with newly identified genes. Future studies, in combination with data on gene expression and epigenetics, are expected to increase our understanding of the pathogenesis of allergy.

OriginalsprogEngelsk
TidsskriftCurrent Opinion in Immunology
Vol/bind36
Sider (fra-til)115-26
Antal sider12
ISSN0952-7915
DOI
StatusUdgivet - okt. 2015

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