TY - JOUR
T1 - Genetically Inferred Telomere Length and Testicular Germ Cell Tumor Risk
AU - Brown, Derek W
AU - Lan, Qing
AU - Rothman, Nathaniel
AU - Pluta, John
AU - Almstrup, Kristian
AU - Dalgaard, Marlene D
AU - Greene, Mark H
AU - Grotmol, Tom
AU - Loveday, Chey
AU - Schwartz, Stephen M
AU - Turnbull, Clare
AU - Wiklund, Fredrik
AU - Kanetsky, Peter A
AU - Nathanson, Katherine L
AU - McGlynn, Katherine A
AU - Machiela, Mitchell J
AU - Testicular Cancer Consortium
N1 - ©2021 American Association for Cancer Research.
PY - 2021/6
Y1 - 2021/6
N2 - BACKGROUND: Studies evaluating the association between peripheral blood leukocyte telomere length (LTL) and testicular germ cell tumor (TGCT) risk have produced conflicting results.METHODS: Using available genotype data from the Testicular Cancer Consortium (TECAC), polygenic risk score and Mendelian randomization analyses of genetic variants previously associated with LTL were used to assess potential etiologic associations between telomere length and TGCT risk.RESULTS: Genetically inferred telomere length was not associated with TGCT risk among 2,049 cases and 6,921 controls with individual-level genotype data (OR, 1.02; 95% confidence interval, 0.97-1.07). Mendelian randomization analyses using summary statistic data further indicated no evidence for an association between telomere length and TGCT risk among all available TECAC participants (3,558 cases and 13,971 controls).CONCLUSIONS: Our analyses in the largest molecular genetic testicular cancer study to date provide no evidence for an association between genetically inferred peripheral blood LTL and TGCT risk.IMPACT: The lack of evidence for an overall association indicates that peripheral blood LTL is likely not a strong biomarker for TGCT risk.
AB - BACKGROUND: Studies evaluating the association between peripheral blood leukocyte telomere length (LTL) and testicular germ cell tumor (TGCT) risk have produced conflicting results.METHODS: Using available genotype data from the Testicular Cancer Consortium (TECAC), polygenic risk score and Mendelian randomization analyses of genetic variants previously associated with LTL were used to assess potential etiologic associations between telomere length and TGCT risk.RESULTS: Genetically inferred telomere length was not associated with TGCT risk among 2,049 cases and 6,921 controls with individual-level genotype data (OR, 1.02; 95% confidence interval, 0.97-1.07). Mendelian randomization analyses using summary statistic data further indicated no evidence for an association between telomere length and TGCT risk among all available TECAC participants (3,558 cases and 13,971 controls).CONCLUSIONS: Our analyses in the largest molecular genetic testicular cancer study to date provide no evidence for an association between genetically inferred peripheral blood LTL and TGCT risk.IMPACT: The lack of evidence for an overall association indicates that peripheral blood LTL is likely not a strong biomarker for TGCT risk.
KW - Case-Control Studies
KW - Genetic Predisposition to Disease
KW - Humans
KW - Male
KW - Mendelian Randomization Analysis
KW - Neoplasms, Germ Cell and Embryonal/epidemiology
KW - Risk Assessment/statistics & numerical data
KW - Risk Factors
KW - Telomere/metabolism
KW - Telomere Homeostasis/genetics
KW - Testicular Neoplasms/epidemiology
UR - http://www.scopus.com/inward/record.url?scp=85107007854&partnerID=8YFLogxK
U2 - 10.1158/1055-9965.EPI-20-1775
DO - 10.1158/1055-9965.EPI-20-1775
M3 - Journal article
C2 - 33737296
SN - 1055-9965
VL - 30
SP - 1275
EP - 1278
JO - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
IS - 6
ER -