Genetic variation in insulin-like growth factor 2 may play a role in ovarian cancer risk

Celeste Leigh Pearce, Jennifer A Doherty, David J Van Den Berg, Kirsten Moysich, Chris Hsu, Kara L Cushing-Haugen, David V Conti, Susan J Ramus, Aleksandra Gentry-Maharaj, Usha Menon, Simon A Gayther, Paul D P Pharoah, Honglin Song, Susanne K Kjaer, Estrid Hogdall, Claus Hogdall, Alice S Whittemore, Valerie McGuire, Weiva Sieh, Jacek GronwaldKrzysztof Medrek, Anna Jakubowska, Jan Lubinski, Georgia Chenevix-Trench, Jonathan Beesley, Penelope M Webb, Andrew Berchuck, Joellen M Schildkraut, Edwin S Iversen, Patricia G Moorman, Christopher K Edlund, Daniel O Stram, Malcolm C Pike, Roberta B Ness, Mary Anne Rossing, Anna H Wu, AOCS/ACS Study Group

    23 Citationer (Scopus)

    Abstract

    The insulin-like growth factor (IGF) signaling axis plays an important role in cancer biology. We hypothesized that genetic variation in this pathway may influence risk of ovarian cancer. A three-center study of non-Hispanic whites including 1880 control women, 1135 women with invasive epithelial ovarian cancer and 321 women with borderline epithelial ovarian tumors was carried out to test the association between tag single-nucleotide polymorphisms (tSNPs) (n=58) in this pathway and risk of ovarian cancer. We found no association between variation in IGF1, IGFBP1 or IGFBP3 and risk of invasive disease, whereas five tSNPs in IGF2 were associated with risk of invasive epithelial ovarian cancer at P
    OriginalsprogEngelsk
    TidsskriftHuman Molecular Genetics
    Vol/bind20
    Udgave nummer11
    Sider (fra-til)2263-72
    Antal sider10
    ISSN0964-6906
    DOI
    StatusUdgivet - 1 jun. 2011

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