Abstract
The insulin-like growth factor (IGF) signaling axis plays an important role in cancer biology. We hypothesized that genetic variation in this pathway may influence risk of ovarian cancer. A three-center study of non-Hispanic whites including 1880 control women, 1135 women with invasive epithelial ovarian cancer and 321 women with borderline epithelial ovarian tumors was carried out to test the association between tag single-nucleotide polymorphisms (tSNPs) (n=58) in this pathway and risk of ovarian cancer. We found no association between variation in IGF1, IGFBP1 or IGFBP3 and risk of invasive disease, whereas five tSNPs in IGF2 were associated with risk of invasive epithelial ovarian cancer at P
Originalsprog | Engelsk |
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Tidsskrift | Human Molecular Genetics |
Vol/bind | 20 |
Udgave nummer | 11 |
Sider (fra-til) | 2263-72 |
Antal sider | 10 |
ISSN | 0964-6906 |
DOI | |
Status | Udgivet - 1 jun. 2011 |