Genetic variants in toll-like receptors are not associated with rheumatoid arthritis susceptibility or anti-tumour necrosis factor treatment outcome

Marieke J H Coenen; Christian Enevold; Pilar Barrera; Mascha M V A P Schijvenaars; Erik J M Toonen; Hans Scheffer; Leonid Padyukov; Alf Kastbom; Lars Klareskog; Anne Barton; Wietske Kievit; Maarten J Rood; Tim L Jansen; Dorine Swinkels; Piet L C M van Riel; Barbara Franke; Klaus Bendtzen; Timothy R D J Radstake

doi:10.1371/journal.pone.0014326

Genetic variants in toll-like receptors are not associated with rheumatoid arthritis susceptibility or anti-tumour necrosis factor treatment outcome

Marieke J H Coenen, Christian Enevold, Pilar Barrera, Mascha M V A P Schijvenaars, Erik J M Toonen, Hans Scheffer, Leonid Padyukov, Alf Kastbom, Lars Klareskog, Anne Barton, Wietske Kievit, Maarten J Rood, Tim L Jansen, Dorine Swinkels, Piet L C M van Riel, Barbara Franke, Klaus Bendtzen, Timothy R D J Radstake

29 Citationer (Scopus)

Abstract

Several studies point to a role of Toll-like receptors (TLRs) in the development of rheumatoid arthritis (RA). We investigated if genetic variants in TLR genes are associated with RA and response to tumour necrosis factor blocking (anti-TNF) medication.

Originalsprog	Engelsk
Tidsskrift	P L o S One
Vol/bind	5
Udgave nummer	12
Sider (fra-til)	e14326
ISSN	1932-6203
DOI	https://doi.org/10.1371/journal.pone.0014326
Status	Udgivet - 1 jan. 2010

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10.1371/journal.pone.0014326

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Coenen, M. J. H., Enevold, C., Barrera, P., Schijvenaars, M. M. V. A. P., Toonen, E. J. M., Scheffer, H., Padyukov, L., Kastbom, A., Klareskog, L., Barton, A., Kievit, W., Rood, M. J., Jansen, T. L., Swinkels, D., van Riel, P. L. C. M., Franke, B., Bendtzen, K., & Radstake, T. R. D. J. (2010). Genetic variants in toll-like receptors are not associated with rheumatoid arthritis susceptibility or anti-tumour necrosis factor treatment outcome. P L o S One, 5(12), e14326. https://doi.org/10.1371/journal.pone.0014326

Coenen, MJH, Enevold, C, Barrera, P, Schijvenaars, MMVAP, Toonen, EJM, Scheffer, H, Padyukov, L, Kastbom, A, Klareskog, L, Barton, A, Kievit, W, Rood, MJ, Jansen, TL, Swinkels, D, van Riel, PLCM, Franke, B, Bendtzen, K & Radstake, TRDJ 2010, 'Genetic variants in toll-like receptors are not associated with rheumatoid arthritis susceptibility or anti-tumour necrosis factor treatment outcome', P L o S One, bind 5, nr. 12, s. e14326. https://doi.org/10.1371/journal.pone.0014326

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abstract = "Several studies point to a role of Toll-like receptors (TLRs) in the development of rheumatoid arthritis (RA). We investigated if genetic variants in TLR genes are associated with RA and response to tumour necrosis factor blocking (anti-TNF) medication.",

author = "Coenen, {Marieke J H} and Christian Enevold and Pilar Barrera and Schijvenaars, {Mascha M V A P} and Toonen, {Erik J M} and Hans Scheffer and Leonid Padyukov and Alf Kastbom and Lars Klareskog and Anne Barton and Wietske Kievit and Rood, {Maarten J} and Jansen, {Tim L} and Dorine Swinkels and {van Riel}, {Piet L C M} and Barbara Franke and Klaus Bendtzen and Radstake, {Timothy R D J}",

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T1 - Genetic variants in toll-like receptors are not associated with rheumatoid arthritis susceptibility or anti-tumour necrosis factor treatment outcome

AU - Coenen, Marieke J H

AU - Enevold, Christian

AU - Barrera, Pilar

AU - Schijvenaars, Mascha M V A P

AU - Toonen, Erik J M

AU - Scheffer, Hans

AU - Padyukov, Leonid

AU - Kastbom, Alf

AU - Klareskog, Lars

AU - Barton, Anne

AU - Kievit, Wietske

AU - Rood, Maarten J

AU - Jansen, Tim L

AU - Swinkels, Dorine

AU - van Riel, Piet L C M

AU - Franke, Barbara

AU - Bendtzen, Klaus

AU - Radstake, Timothy R D J

PY - 2010/1/1

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N2 - Several studies point to a role of Toll-like receptors (TLRs) in the development of rheumatoid arthritis (RA). We investigated if genetic variants in TLR genes are associated with RA and response to tumour necrosis factor blocking (anti-TNF) medication.

AB - Several studies point to a role of Toll-like receptors (TLRs) in the development of rheumatoid arthritis (RA). We investigated if genetic variants in TLR genes are associated with RA and response to tumour necrosis factor blocking (anti-TNF) medication.

U2 - 10.1371/journal.pone.0014326

DO - 10.1371/journal.pone.0014326

M3 - Journal article

C2 - 21179534

SN - 1932-6203

VL - 5

SP - e14326

JO - P L o S One

JF - P L o S One

IS - 12

ER -

Genetic variants in toll-like receptors are not associated with rheumatoid arthritis susceptibility or anti-tumour necrosis factor treatment outcome

Abstract

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