TY - JOUR
T1 - Genetic Susceptibility to Sepsis
T2 - A Possible Role for Mannose-binding Lectin
AU - Garred, Peter
AU - Madsen, Hans O
PY - 2004/10
Y1 - 2004/10
N2 - Sepsis is an increasing problem in modern medicine and the leading cause of death in noncoronary intensive care unit patients. Over the past few years, several studies have provided data indicating that relatively common polymorphisms in genes encoding proteins of importance for innate immune recognition, the inflammatory response, and for coagulation and fibrinolysis, are associated with susceptibility for and outcome of sepsis. Recently, several studies have shed light on the importance of deficiency of mannose-binding lectin (MBL) as a susceptibility factor for sepsis. This review summarizes the evidence that critically ill patients carrying MBL-variant alleles may be at increased risk for severe sepsis. The prospect for the future is that genetic profiling may guide in identifying critically ill patients at increased risk for sepsis and poor outcome, and in tailoring a more individual and effective therapy.
AB - Sepsis is an increasing problem in modern medicine and the leading cause of death in noncoronary intensive care unit patients. Over the past few years, several studies have provided data indicating that relatively common polymorphisms in genes encoding proteins of importance for innate immune recognition, the inflammatory response, and for coagulation and fibrinolysis, are associated with susceptibility for and outcome of sepsis. Recently, several studies have shed light on the importance of deficiency of mannose-binding lectin (MBL) as a susceptibility factor for sepsis. This review summarizes the evidence that critically ill patients carrying MBL-variant alleles may be at increased risk for severe sepsis. The prospect for the future is that genetic profiling may guide in identifying critically ill patients at increased risk for sepsis and poor outcome, and in tailoring a more individual and effective therapy.
U2 - 10.1007/s11908-004-0035-0
DO - 10.1007/s11908-004-0035-0
M3 - Journal article
C2 - 15461887
SN - 1523-3847
VL - 6
SP - 367
EP - 373
JO - Current Infectious Disease Reports
JF - Current Infectious Disease Reports
IS - 5
ER -