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Genetic Susceptibility Loci in Genomewide Association Study of Cluster Headache

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Harvard

Harder, AVE, Winsvold, BS, Noordam, R, Vijfhuizen, LS, Børte, S, Kogelman, LJA, de Boer, I, Tronvik, E, Rosendaal, FR, Willems van Dijk, K, O'Connor, E, Fourier, C, Thomas, LF, Kristoffersen, ES, Fronczek, R, Pozo-Rosich, P, Jensen, RH, Ferrari, MD, Hansen, TF, Zwart, J-A, Terwindt, GM, van den Maagdenberg, AMJM & Cluster Headache Genetics Working Group 2021, 'Genetic Susceptibility Loci in Genomewide Association Study of Cluster Headache', Annals of Neurology, bind 90, nr. 2, s. 203-216. https://doi.org/10.1002/ana.26146

APA

Harder, A. V. E., Winsvold, B. S., Noordam, R., Vijfhuizen, L. S., Børte, S., Kogelman, L. J. A., de Boer, I., Tronvik, E., Rosendaal, F. R., Willems van Dijk, K., O'Connor, E., Fourier, C., Thomas, L. F., Kristoffersen, E. S., Fronczek, R., Pozo-Rosich, P., Jensen, R. H., Ferrari, M. D., Hansen, T. F., ... Cluster Headache Genetics Working Group (2021). Genetic Susceptibility Loci in Genomewide Association Study of Cluster Headache. Annals of Neurology, 90(2), 203-216. https://doi.org/10.1002/ana.26146

CBE

Harder AVE, Winsvold BS, Noordam R, Vijfhuizen LS, Børte S, Kogelman LJA, de Boer I, Tronvik E, Rosendaal FR, Willems van Dijk K, O'Connor E, Fourier C, Thomas LF, Kristoffersen ES, Fronczek R, Pozo-Rosich P, Jensen RH, Ferrari MD, Hansen TF, Zwart J-A, Terwindt GM, van den Maagdenberg AMJM, Cluster Headache Genetics Working Group. 2021. Genetic Susceptibility Loci in Genomewide Association Study of Cluster Headache. Annals of Neurology. 90(2):203-216. https://doi.org/10.1002/ana.26146

MLA

Vancouver

Author

Harder, Aster V E ; Winsvold, Bendik S ; Noordam, Raymond ; Vijfhuizen, Lisanne S ; Børte, Sigrid ; Kogelman, Lisette J A ; de Boer, Irene ; Tronvik, Erling ; Rosendaal, Frits R ; Willems van Dijk, Ko ; O'Connor, Emer ; Fourier, Carmen ; Thomas, Laurent F ; Kristoffersen, Espen S ; Fronczek, Rolf ; Pozo-Rosich, Patricia ; Jensen, Rigmor H ; Ferrari, Michel D ; Hansen, Thomas F ; Zwart, John-Anker ; Terwindt, Gisela M ; van den Maagdenberg, Arn M J M ; Cluster Headache Genetics Working Group. / Genetic Susceptibility Loci in Genomewide Association Study of Cluster Headache. I: Annals of Neurology. 2021 ; Bind 90, Nr. 2. s. 203-216.

Bibtex

@article{84bd1f042e3e472ca5f65f9e62085c75,
title = "Genetic Susceptibility Loci in Genomewide Association Study of Cluster Headache",
abstract = "OBJECTIVE: Identifying common genetic variants that confer genetic risk for cluster headache.METHODS: We conducted a case-control study in the Dutch Leiden University Cluster headache neuro-Analysis program (LUCA) study population (n = 840) and unselected controls from the Netherlands Epidemiology of Obesity Study (NEO; n = 1,457). Replication was performed in a Norwegian sample of 144 cases from the Trondheim Cluster headache sample and 1,800 controls from the Nord-Tr{\o}ndelag Health Survey (HUNT). Gene set and tissue enrichment analyses, blood cell-derived RNA-sequencing of genes around the risk loci and linkage disequilibrium score regression were part of the downstream analyses.RESULTS: An association was found with cluster headache for 4 independent loci (r2  < 0.1) with genomewide significance (p < 5 × 10-8 ), rs11579212 (odds ratio [OR] = 1.51, 95% confidence interval [CI] = 1.33-1.72 near RP11-815 M8.1), rs6541998 (OR = 1.53, 95% CI = 1.37-1.74 near MERTK), rs10184573 (OR = 1.43, 95% CI = 1.26-1.61 near AC093590.1), and rs2499799 (OR = 0.62, 95% CI = 0.54-0.73 near UFL1/FHL5), collectively explaining 7.2% of the variance of cluster headache. SNPs rs11579212, rs10184573, and rs976357, as proxy SNP for rs2499799 (r2 = 1.0), replicated in the Norwegian sample (p < 0.05). Gene-based mapping yielded ASZ1 as possible fifth locus. RNA-sequencing indicated differential expression of POLR1B and TMEM87B in cluster headache patients.INTERPRETATION: This genomewide association study (GWAS) identified and replicated genetic risk loci for cluster headache with effect sizes larger than those typically seen in complex genetic disorders. ANN NEUROL 2021;90:203-216.",
author = "Harder, {Aster V E} and Winsvold, {Bendik S} and Raymond Noordam and Vijfhuizen, {Lisanne S} and Sigrid B{\o}rte and Kogelman, {Lisette J A} and {de Boer}, Irene and Erling Tronvik and Rosendaal, {Frits R} and {Willems van Dijk}, Ko and Emer O'Connor and Carmen Fourier and Thomas, {Laurent F} and Kristoffersen, {Espen S} and Rolf Fronczek and Patricia Pozo-Rosich and Jensen, {Rigmor H} and Ferrari, {Michel D} and Hansen, {Thomas F} and John-Anker Zwart and Terwindt, {Gisela M} and {van den Maagdenberg}, {Arn M J M} and {Cluster Headache Genetics Working Group}",
note = "This article is protected by copyright. All rights reserved.",
year = "2021",
month = aug,
doi = "10.1002/ana.26146",
language = "English",
volume = "90",
pages = "203--216",
journal = "Annals of Neurology",
issn = "0364-5134",
publisher = "John/Wiley & Sons, Inc. John/Wiley & Sons Ltd",
number = "2",

}

RIS

TY - JOUR

T1 - Genetic Susceptibility Loci in Genomewide Association Study of Cluster Headache

AU - Harder, Aster V E

AU - Winsvold, Bendik S

AU - Noordam, Raymond

AU - Vijfhuizen, Lisanne S

AU - Børte, Sigrid

AU - Kogelman, Lisette J A

AU - de Boer, Irene

AU - Tronvik, Erling

AU - Rosendaal, Frits R

AU - Willems van Dijk, Ko

AU - O'Connor, Emer

AU - Fourier, Carmen

AU - Thomas, Laurent F

AU - Kristoffersen, Espen S

AU - Fronczek, Rolf

AU - Pozo-Rosich, Patricia

AU - Jensen, Rigmor H

AU - Ferrari, Michel D

AU - Hansen, Thomas F

AU - Zwart, John-Anker

AU - Terwindt, Gisela M

AU - van den Maagdenberg, Arn M J M

AU - Cluster Headache Genetics Working Group

N1 - This article is protected by copyright. All rights reserved.

PY - 2021/8

Y1 - 2021/8

N2 - OBJECTIVE: Identifying common genetic variants that confer genetic risk for cluster headache.METHODS: We conducted a case-control study in the Dutch Leiden University Cluster headache neuro-Analysis program (LUCA) study population (n = 840) and unselected controls from the Netherlands Epidemiology of Obesity Study (NEO; n = 1,457). Replication was performed in a Norwegian sample of 144 cases from the Trondheim Cluster headache sample and 1,800 controls from the Nord-Trøndelag Health Survey (HUNT). Gene set and tissue enrichment analyses, blood cell-derived RNA-sequencing of genes around the risk loci and linkage disequilibrium score regression were part of the downstream analyses.RESULTS: An association was found with cluster headache for 4 independent loci (r2  < 0.1) with genomewide significance (p < 5 × 10-8 ), rs11579212 (odds ratio [OR] = 1.51, 95% confidence interval [CI] = 1.33-1.72 near RP11-815 M8.1), rs6541998 (OR = 1.53, 95% CI = 1.37-1.74 near MERTK), rs10184573 (OR = 1.43, 95% CI = 1.26-1.61 near AC093590.1), and rs2499799 (OR = 0.62, 95% CI = 0.54-0.73 near UFL1/FHL5), collectively explaining 7.2% of the variance of cluster headache. SNPs rs11579212, rs10184573, and rs976357, as proxy SNP for rs2499799 (r2 = 1.0), replicated in the Norwegian sample (p < 0.05). Gene-based mapping yielded ASZ1 as possible fifth locus. RNA-sequencing indicated differential expression of POLR1B and TMEM87B in cluster headache patients.INTERPRETATION: This genomewide association study (GWAS) identified and replicated genetic risk loci for cluster headache with effect sizes larger than those typically seen in complex genetic disorders. ANN NEUROL 2021;90:203-216.

AB - OBJECTIVE: Identifying common genetic variants that confer genetic risk for cluster headache.METHODS: We conducted a case-control study in the Dutch Leiden University Cluster headache neuro-Analysis program (LUCA) study population (n = 840) and unselected controls from the Netherlands Epidemiology of Obesity Study (NEO; n = 1,457). Replication was performed in a Norwegian sample of 144 cases from the Trondheim Cluster headache sample and 1,800 controls from the Nord-Trøndelag Health Survey (HUNT). Gene set and tissue enrichment analyses, blood cell-derived RNA-sequencing of genes around the risk loci and linkage disequilibrium score regression were part of the downstream analyses.RESULTS: An association was found with cluster headache for 4 independent loci (r2  < 0.1) with genomewide significance (p < 5 × 10-8 ), rs11579212 (odds ratio [OR] = 1.51, 95% confidence interval [CI] = 1.33-1.72 near RP11-815 M8.1), rs6541998 (OR = 1.53, 95% CI = 1.37-1.74 near MERTK), rs10184573 (OR = 1.43, 95% CI = 1.26-1.61 near AC093590.1), and rs2499799 (OR = 0.62, 95% CI = 0.54-0.73 near UFL1/FHL5), collectively explaining 7.2% of the variance of cluster headache. SNPs rs11579212, rs10184573, and rs976357, as proxy SNP for rs2499799 (r2 = 1.0), replicated in the Norwegian sample (p < 0.05). Gene-based mapping yielded ASZ1 as possible fifth locus. RNA-sequencing indicated differential expression of POLR1B and TMEM87B in cluster headache patients.INTERPRETATION: This genomewide association study (GWAS) identified and replicated genetic risk loci for cluster headache with effect sizes larger than those typically seen in complex genetic disorders. ANN NEUROL 2021;90:203-216.

UR - http://www.scopus.com/inward/record.url?scp=85111466295&partnerID=8YFLogxK

U2 - 10.1002/ana.26146

DO - 10.1002/ana.26146

M3 - Journal article

C2 - 34180076

VL - 90

SP - 203

EP - 216

JO - Annals of Neurology

JF - Annals of Neurology

SN - 0364-5134

IS - 2

ER -

ID: 66500117