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Genetic Susceptibility Loci in Genomewide Association Study of Cluster Headache

Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review


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  • Aster V E Harder
  • Bendik S Winsvold
  • Raymond Noordam
  • Lisanne S Vijfhuizen
  • Sigrid Børte
  • Lisette J A Kogelman
  • Irene de Boer
  • Erling Tronvik
  • Frits R Rosendaal
  • Ko Willems van Dijk
  • Emer O'Connor
  • Carmen Fourier
  • Laurent F Thomas
  • Espen S Kristoffersen
  • Rolf Fronczek
  • Patricia Pozo-Rosich
  • Rigmor H Jensen
  • Michel D Ferrari
  • Thomas F Hansen
  • John-Anker Zwart
  • Gisela M Terwindt
  • Arn M J M van den Maagdenberg
  • Cluster Headache Genetics Working Group
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OBJECTIVE: Identifying common genetic variants that confer genetic risk for cluster headache.

METHODS: We conducted a case-control study in the Dutch Leiden University Cluster headache neuro-Analysis program (LUCA) study population (n = 840) and unselected controls from the Netherlands Epidemiology of Obesity Study (NEO; n = 1,457). Replication was performed in a Norwegian sample of 144 cases from the Trondheim Cluster headache sample and 1,800 controls from the Nord-Trøndelag Health Survey (HUNT). Gene set and tissue enrichment analyses, blood cell-derived RNA-sequencing of genes around the risk loci and linkage disequilibrium score regression were part of the downstream analyses.

RESULTS: An association was found with cluster headache for 4 independent loci (r2  < 0.1) with genomewide significance (p < 5 × 10-8 ), rs11579212 (odds ratio [OR] = 1.51, 95% confidence interval [CI] = 1.33-1.72 near RP11-815 M8.1), rs6541998 (OR = 1.53, 95% CI = 1.37-1.74 near MERTK), rs10184573 (OR = 1.43, 95% CI = 1.26-1.61 near AC093590.1), and rs2499799 (OR = 0.62, 95% CI = 0.54-0.73 near UFL1/FHL5), collectively explaining 7.2% of the variance of cluster headache. SNPs rs11579212, rs10184573, and rs976357, as proxy SNP for rs2499799 (r2 = 1.0), replicated in the Norwegian sample (p < 0.05). Gene-based mapping yielded ASZ1 as possible fifth locus. RNA-sequencing indicated differential expression of POLR1B and TMEM87B in cluster headache patients.

INTERPRETATION: This genomewide association study (GWAS) identified and replicated genetic risk loci for cluster headache with effect sizes larger than those typically seen in complex genetic disorders. ANN NEUROL 2021;90:203-216.

TidsskriftAnnals of Neurology
Udgave nummer2
Sider (fra-til)203-216
Antal sider14
StatusUdgivet - aug. 2021

ID: 66500117