Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies

Matthew Traylor; Martin Farrall; Elizabeth G Holliday; Cathie Sudlow; Jemma C Hopewell; Yu-Ching Cheng; Myriam Fornage; M Arfan Ikram; Rainer Malik; Steve Bevan; Unnur Thorsteinsdottir; Mike A Nalls; Wt Longstreth; Kerri L Wiggins; Sunaina Yadav; Eugenio A Parati; Anita L Destefano; Bradford B Worrall; Steven J Kittner; Muhammad Saleem Khan; Alex P Reiner; Anna Helgadottir; Sefanja Achterberg; Israel Fernandez-Cadenas; Sherine Abboud; Reinhold Schmidt; Matthew Walters; Wei-Min Chen; E Bernd Ringelstein; Martin O'Donnell; Weang Kee Ho; Joanna Pera; Robin Lemmens; Bo Norrving; Peter Higgins; Marianne Benn; Michele Sale; Gregor Kuhlenbäumer; Alexander S F Doney; Astrid M Vicente; Hossein Delavaran; Ale Algra; Gail Davies; Sofia A Oliveira; Colin N A Palmer; Ian Deary; Helena Schmidt; Massimo Pandolfo; Joan Montaner; Børge G Nordestgaard; Australian Stroke Genetics Collaborative, Wellcome Trust Case Control Consortium 2 (WTCCC2)

doi:10.1016/S1474-4422(12)70234-X

Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies

Matthew Traylor, Martin Farrall, Elizabeth G Holliday, Cathie Sudlow, Jemma C Hopewell, Yu-Ching Cheng, Myriam Fornage, M Arfan Ikram, Rainer Malik, Steve Bevan, Unnur Thorsteinsdottir, Mike A Nalls, Wt Longstreth, Kerri L Wiggins, Sunaina Yadav, Eugenio A Parati, Anita L Destefano, Bradford B Worrall, Steven J Kittner, Muhammad Saleem KhanAlex P Reiner, Anna Helgadottir, Sefanja Achterberg, Israel Fernandez-Cadenas, Sherine Abboud, Reinhold Schmidt, Matthew Walters, Wei-Min Chen, E Bernd Ringelstein, Martin O'Donnell, Weang Kee Ho, Joanna Pera, Robin Lemmens, Bo Norrving, Peter Higgins, Marianne Benn, Michele Sale, Gregor Kuhlenbäumer, Alexander S F Doney, Astrid M Vicente, Hossein Delavaran, Ale Algra, Gail Davies, Sofia A Oliveira, Colin N A Palmer, Ian Deary, Helena Schmidt, Massimo Pandolfo, Joan Montaner, Børge G Nordestgaard, Australian Stroke Genetics Collaborative, Wellcome Trust Case Control Consortium 2 (WTCCC2)

400 Citationer (Scopus)

Abstract

Various genome-wide association studies (GWAS) have been done in ischaemic stroke, identifying a few loci associated with the disease, but sample sizes have been 3500 cases or less. We established the METASTROKE collaboration with the aim of validating associations from previous GWAS and identifying novel genetic associations through meta-analysis of GWAS datasets for ischaemic stroke and its subtypes.

Originalsprog	Engelsk
Tidsskrift	Lancet neurology
Vol/bind	11
Udgave nummer	11
Sider (fra-til)	951-62
Antal sider	12
ISSN	1474-4422
DOI	https://doi.org/10.1016/S1474-4422(12)70234-X
Status	Udgivet - 2012

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10.1016/S1474-4422(12)70234-X

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Traylor, M., Farrall, M., Holliday, E. G., Sudlow, C., Hopewell, J. C., Cheng, Y.-C., Fornage, M., Ikram, M. A., Malik, R., Bevan, S., Thorsteinsdottir, U., Nalls, M. A., Longstreth, W., Wiggins, K. L., Yadav, S., Parati, E. A., Destefano, A. L., Worrall, B. B., Kittner, S. J., ... Australian Stroke Genetics Collaborative, Wellcome Trust Case Control Consortium 2 (WTCCC2) (2012). Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies. Lancet neurology, 11(11), 951-62. https://doi.org/10.1016/S1474-4422(12)70234-X

Traylor, M, Farrall, M, Holliday, EG, Sudlow, C, Hopewell, JC, Cheng, Y-C, Fornage, M, Ikram, MA, Malik, R, Bevan, S, Thorsteinsdottir, U, Nalls, MA, Longstreth, W, Wiggins, KL, Yadav, S, Parati, EA, Destefano, AL, Worrall, BB, Kittner, SJ, Khan, MS, Reiner, AP, Helgadottir, A, Achterberg, S, Fernandez-Cadenas, I, Abboud, S, Schmidt, R, Walters, M, Chen, W-M, Ringelstein, EB, O'Donnell, M, Ho, WK, Pera, J, Lemmens, R, Norrving, B, Higgins, P, Benn, M, Sale, M, Kuhlenbäumer, G, Doney, ASF, Vicente, AM, Delavaran, H, Algra, A, Davies, G, Oliveira, SA, Palmer, CNA, Deary, I, Schmidt, H, Pandolfo, M, Montaner, J, Nordestgaard, BG & Australian Stroke Genetics Collaborative, Wellcome Trust Case Control Consortium 2 (WTCCC2) 2012, 'Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies', Lancet neurology, bind 11, nr. 11, s. 951-62. https://doi.org/10.1016/S1474-4422(12)70234-X

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title = "Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies",

abstract = "Various genome-wide association studies (GWAS) have been done in ischaemic stroke, identifying a few loci associated with the disease, but sample sizes have been 3500 cases or less. We established the METASTROKE collaboration with the aim of validating associations from previous GWAS and identifying novel genetic associations through meta-analysis of GWAS datasets for ischaemic stroke and its subtypes.",

keywords = "Brain Ischemia, Databases, Genetic, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Risk Factors, Stroke",

author = "Matthew Traylor and Martin Farrall and Holliday, {Elizabeth G} and Cathie Sudlow and Hopewell, {Jemma C} and Yu-Ching Cheng and Myriam Fornage and Ikram, {M Arfan} and Rainer Malik and Steve Bevan and Unnur Thorsteinsdottir and Nalls, {Mike A} and Wt Longstreth and Wiggins, {Kerri L} and Sunaina Yadav and Parati, {Eugenio A} and Destefano, {Anita L} and Worrall, {Bradford B} and Kittner, {Steven J} and Khan, {Muhammad Saleem} and Reiner, {Alex P} and Anna Helgadottir and Sefanja Achterberg and Israel Fernandez-Cadenas and Sherine Abboud and Reinhold Schmidt and Matthew Walters and Wei-Min Chen and Ringelstein, {E Bernd} and Martin O'Donnell and Ho, {Weang Kee} and Joanna Pera and Robin Lemmens and Bo Norrving and Peter Higgins and Marianne Benn and Michele Sale and Gregor Kuhlenb{\"a}umer and Doney, {Alexander S F} and Vicente, {Astrid M} and Hossein Delavaran and Ale Algra and Gail Davies and Oliveira, {Sofia A} and Palmer, {Colin N A} and Ian Deary and Helena Schmidt and Massimo Pandolfo and Joan Montaner and Nordestgaard, {B{\o}rge G} and {Australian Stroke Genetics Collaborative, Wellcome Trust Case Control Consortium 2 (WTCCC2)}",

year = "2012",

doi = "10.1016/S1474-4422(12)70234-X",

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AU - Traylor, Matthew

AU - Farrall, Martin

AU - Holliday, Elizabeth G

AU - Sudlow, Cathie

AU - Hopewell, Jemma C

AU - Cheng, Yu-Ching

AU - Fornage, Myriam

AU - Ikram, M Arfan

AU - Malik, Rainer

AU - Bevan, Steve

AU - Thorsteinsdottir, Unnur

AU - Nalls, Mike A

AU - Longstreth, Wt

AU - Wiggins, Kerri L

AU - Yadav, Sunaina

AU - Parati, Eugenio A

AU - Destefano, Anita L

AU - Worrall, Bradford B

AU - Kittner, Steven J

AU - Khan, Muhammad Saleem

AU - Reiner, Alex P

AU - Helgadottir, Anna

AU - Achterberg, Sefanja

AU - Fernandez-Cadenas, Israel

AU - Abboud, Sherine

AU - Schmidt, Reinhold

AU - Walters, Matthew

AU - Chen, Wei-Min

AU - Ringelstein, E Bernd

AU - O'Donnell, Martin

AU - Ho, Weang Kee

AU - Pera, Joanna

AU - Lemmens, Robin

AU - Norrving, Bo

AU - Higgins, Peter

AU - Benn, Marianne

AU - Sale, Michele

AU - Kuhlenbäumer, Gregor

AU - Doney, Alexander S F

AU - Vicente, Astrid M

AU - Delavaran, Hossein

AU - Algra, Ale

AU - Davies, Gail

AU - Oliveira, Sofia A

AU - Palmer, Colin N A

AU - Deary, Ian

AU - Schmidt, Helena

AU - Pandolfo, Massimo

AU - Montaner, Joan

AU - Nordestgaard, Børge G

AU - Australian Stroke Genetics Collaborative, Wellcome Trust Case Control Consortium 2 (WTCCC2)

PY - 2012

Y1 - 2012

N2 - Various genome-wide association studies (GWAS) have been done in ischaemic stroke, identifying a few loci associated with the disease, but sample sizes have been 3500 cases or less. We established the METASTROKE collaboration with the aim of validating associations from previous GWAS and identifying novel genetic associations through meta-analysis of GWAS datasets for ischaemic stroke and its subtypes.

AB - Various genome-wide association studies (GWAS) have been done in ischaemic stroke, identifying a few loci associated with the disease, but sample sizes have been 3500 cases or less. We established the METASTROKE collaboration with the aim of validating associations from previous GWAS and identifying novel genetic associations through meta-analysis of GWAS datasets for ischaemic stroke and its subtypes.

KW - Brain Ischemia

KW - Databases, Genetic

KW - Genetic Predisposition to Disease

KW - Genome-Wide Association Study

KW - Humans

KW - Risk Factors

KW - Stroke

U2 - 10.1016/S1474-4422(12)70234-X

DO - 10.1016/S1474-4422(12)70234-X

M3 - Journal article

C2 - 23041239

SN - 1474-4422

VL - 11

SP - 951

EP - 962

JO - Lancet neurology

JF - Lancet neurology

IS - 11

ER -

Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies

Abstract

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