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Genetic predisposition to long telomeres is associated with increased mortality after melanoma: A study of 2101 melanoma patients from hospital clinics and the general population

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Vis graf over relationer

Whether there is an association between measured and genetically predicted telomere length and melanoma mortality is unclear. We tested the hypothesis that measured and genetically predicted telomere length is associated with mortality after a melanoma diagnosis. We followed 2,101 patients with melanoma from hospital clinics and the general population for risk of death for up to 26 years. All had telomere length measured in DNA from leukocytes, and 2052 of these were genotyped for the three single nucleotide polymorphisms rs7726159 (TERT), rs1317082 (TERC), and rs2487999 (OBFC1); all three genotypes are associated with telomere length and combined into an allele count from 0 to 6. For each telomere-lengthening allele, the hazard ratios (HRs) for mortality in the age-adjusted and multivariable-adjusted Cox analysis were 1.12 (95% confidence interval: 1.02–1.23) and 1.11 (1.01–1.23). However, for each standard deviation increase in measured telomere length, HR for mortality was 0.97 (0.88–1.08). In conclusion, in more than 2000 melanoma patients from hospital clinics and from the general population, genetically predicted long telomeres were associated with increased mortality, but measured leukocyte telomere length was not.

OriginalsprogEngelsk
TidsskriftPigment Cell and Melanoma Research
Vol/bind34
Udgave nummer5
Sider (fra-til)946-954
Antal sider9
ISSN1755-1471
DOI
StatusUdgivet - sep. 2021

Bibliografisk note

Funding Information:
We thank the Chief Physician Johan Boserup and Lise Boserup's Foundation, the Research Council at Herlev and Gentofte Hospital, the Research Foundation for Health Research in the Capital Region of Denmark, and Sawmill Owner Jeppe Juhl and Wife Ovita Juhl's Memorial Fund for financial assistance. The funders had no influence on any parts of this work nor in the preparation of the paper.

Publisher Copyright:
© 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd

Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.

ID: 66501637