Genetic polymorphisms of the renin-angiotensin system and complications of insulin-dependent diabetes mellitus

F J van Ittersum; A M de Man; S Thijssen; Peter de Knijff; P E Slagboom; Yvo Smulders; L Tarnow; A J Donker; H J G Bilo; C D Stehouwer

Genetic polymorphisms of the renin-angiotensin system and complications of insulin-dependent diabetes mellitus

F J van Ittersum, A M de Man, S Thijssen, Peter de Knijff, P E Slagboom, Yvo Smulders, L Tarnow, A J Donker, H J G Bilo, C D Stehouwer

76 Citationer (Scopus)

Abstract

OBJECTIVE: Patients with insulin-dependent diabetes mellitus (IDDM) have a high risk of developing diabetic nephropathy, retinopathy and cardiovascular diseases. The contribution of gene polymorphisms of the renin angiotensin system to these complications is controversial and may differ among populations.

METHODS: In 257 Dutch IDDM patients (188 with urinary albumin excretion (UAE) <30 mg/24 h), logistic regression analysis was used to study the relationships among, on the one hand, the insertion/deletion gene polymorphism of the angiotensin-converting enzyme gene (ACE-ID), the M235T gene polymorphism of the angiotensinogen gene (AGT-M235T), and the A1166C gene polymorphism of the angiotensin type 1 receptor gene (AT1-A1166C), and, on the other hand, UAE, retinopathy, hypertension, and coronary heart disease.

RESULTS: The T-allele of the AGT-M235T polymorphism was associated with an increased risk of an elevated UAE (odds ratio (OR) 3.03; 95% confidence interval (CI) 1.06-8.61), but only when interaction with the D-allele of the ACE-ID polymorphism was considered. A previously described positive interaction between the T-allele of the AGT-M235T polymorphism and the D-allele of the ACE-ID polymorphism could not be confirmed. The T-allele was also associated with an increased risk of retinopathy (OR 3.89, 95% CI 1.79-8.47). The CC-genotype of the AT1-A1166C polymorphism was associated with hypertension (OR 3.58; 95% CI 1. 23-10.37).

CONCLUSIONS: In a Dutch IDDM population, including 69 patients with (incipient) diabetic nephropathy, the T-allele of the AGT-M235T polymorphism is associated with an elevated UAE and diabetic retinopathy and the CC-genotype of the AT1-A1166C polymorphism is associated with hypertension. A previously described interaction between the AGT-M235T and the ACE-ID polymorphisms could not be confirmed. Since the number of nephropathic patients in this study is small, these conclusions must be interpreted with caution.

Originalsprog	Engelsk
Tidsskrift	Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
Vol/bind	15
Udgave nummer	7
Sider (fra-til)	1000-7
Antal sider	8
ISSN	0931-0509
Status	Udgivet - jul. 2000
Udgivet eksternt	Ja

Citationsformater

van Ittersum, F. J., de Man, A. M., Thijssen, S., de Knijff, P., Slagboom, P. E., Smulders, Y., Tarnow, L., Donker, A. J., Bilo, H. J. G., & Stehouwer, C. D. (2000). Genetic polymorphisms of the renin-angiotensin system and complications of insulin-dependent diabetes mellitus. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 15(7), 1000-7.

Genetic polymorphisms of the renin-angiotensin system and complications of insulin-dependent diabetes mellitus. / van Ittersum, F J; de Man, A M; Thijssen, S et al.
I: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, Bind 15, Nr. 7, 07.2000, s. 1000-7.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

van Ittersum, FJ, de Man, AM, Thijssen, S, de Knijff, P, Slagboom, PE, Smulders, Y, Tarnow, L, Donker, AJ, Bilo, HJG & Stehouwer, CD 2000, 'Genetic polymorphisms of the renin-angiotensin system and complications of insulin-dependent diabetes mellitus', Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, bind 15, nr. 7, s. 1000-7.

@article{694739f5336c4f8c93187137645000d3,

title = "Genetic polymorphisms of the renin-angiotensin system and complications of insulin-dependent diabetes mellitus",

abstract = "OBJECTIVE: Patients with insulin-dependent diabetes mellitus (IDDM) have a high risk of developing diabetic nephropathy, retinopathy and cardiovascular diseases. The contribution of gene polymorphisms of the renin angiotensin system to these complications is controversial and may differ among populations.METHODS: In 257 Dutch IDDM patients (188 with urinary albumin excretion (UAE) <30 mg/24 h), logistic regression analysis was used to study the relationships among, on the one hand, the insertion/deletion gene polymorphism of the angiotensin-converting enzyme gene (ACE-ID), the M235T gene polymorphism of the angiotensinogen gene (AGT-M235T), and the A1166C gene polymorphism of the angiotensin type 1 receptor gene (AT1-A1166C), and, on the other hand, UAE, retinopathy, hypertension, and coronary heart disease.RESULTS: The T-allele of the AGT-M235T polymorphism was associated with an increased risk of an elevated UAE (odds ratio (OR) 3.03; 95% confidence interval (CI) 1.06-8.61), but only when interaction with the D-allele of the ACE-ID polymorphism was considered. A previously described positive interaction between the T-allele of the AGT-M235T polymorphism and the D-allele of the ACE-ID polymorphism could not be confirmed. The T-allele was also associated with an increased risk of retinopathy (OR 3.89, 95% CI 1.79-8.47). The CC-genotype of the AT1-A1166C polymorphism was associated with hypertension (OR 3.58; 95% CI 1. 23-10.37).CONCLUSIONS: In a Dutch IDDM population, including 69 patients with (incipient) diabetic nephropathy, the T-allele of the AGT-M235T polymorphism is associated with an elevated UAE and diabetic retinopathy and the CC-genotype of the AT1-A1166C polymorphism is associated with hypertension. A previously described interaction between the AGT-M235T and the ACE-ID polymorphisms could not be confirmed. Since the number of nephropathic patients in this study is small, these conclusions must be interpreted with caution.",

keywords = "Adult, Aged, Albuminuria, Angiotensinogen, Coronary Disease, DNA Transposable Elements, Diabetes Mellitus, Type 1, Diabetic Angiopathies, Diabetic Nephropathies, Diabetic Retinopathy, Gene Deletion, Humans, Hypertension, Middle Aged, Peptidyl-Dipeptidase A, Polymorphism, Genetic, Receptor, Angiotensin, Type 1, Receptor, Angiotensin, Type 2, Receptors, Angiotensin, Renin-Angiotensin System, Journal Article",

author = "{van Ittersum}, {F J} and {de Man}, {A M} and S Thijssen and {de Knijff}, Peter and Slagboom, {P E} and Yvo Smulders and L Tarnow and Donker, {A J} and Bilo, {H J G} and Stehouwer, {C D}",

year = "2000",

month = jul,

language = "English",

volume = "15",

pages = "1000--7",

journal = "Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association",

issn = "0931-0509",

publisher = "OXFORD UNIV PRESS",

number = "7",

}

TY - JOUR

T1 - Genetic polymorphisms of the renin-angiotensin system and complications of insulin-dependent diabetes mellitus

AU - van Ittersum, F J

AU - de Man, A M

AU - Thijssen, S

AU - de Knijff, Peter

AU - Slagboom, P E

AU - Smulders, Yvo

AU - Tarnow, L

AU - Donker, A J

AU - Bilo, H J G

AU - Stehouwer, C D

PY - 2000/7

Y1 - 2000/7

N2 - OBJECTIVE: Patients with insulin-dependent diabetes mellitus (IDDM) have a high risk of developing diabetic nephropathy, retinopathy and cardiovascular diseases. The contribution of gene polymorphisms of the renin angiotensin system to these complications is controversial and may differ among populations.METHODS: In 257 Dutch IDDM patients (188 with urinary albumin excretion (UAE) <30 mg/24 h), logistic regression analysis was used to study the relationships among, on the one hand, the insertion/deletion gene polymorphism of the angiotensin-converting enzyme gene (ACE-ID), the M235T gene polymorphism of the angiotensinogen gene (AGT-M235T), and the A1166C gene polymorphism of the angiotensin type 1 receptor gene (AT1-A1166C), and, on the other hand, UAE, retinopathy, hypertension, and coronary heart disease.RESULTS: The T-allele of the AGT-M235T polymorphism was associated with an increased risk of an elevated UAE (odds ratio (OR) 3.03; 95% confidence interval (CI) 1.06-8.61), but only when interaction with the D-allele of the ACE-ID polymorphism was considered. A previously described positive interaction between the T-allele of the AGT-M235T polymorphism and the D-allele of the ACE-ID polymorphism could not be confirmed. The T-allele was also associated with an increased risk of retinopathy (OR 3.89, 95% CI 1.79-8.47). The CC-genotype of the AT1-A1166C polymorphism was associated with hypertension (OR 3.58; 95% CI 1. 23-10.37).CONCLUSIONS: In a Dutch IDDM population, including 69 patients with (incipient) diabetic nephropathy, the T-allele of the AGT-M235T polymorphism is associated with an elevated UAE and diabetic retinopathy and the CC-genotype of the AT1-A1166C polymorphism is associated with hypertension. A previously described interaction between the AGT-M235T and the ACE-ID polymorphisms could not be confirmed. Since the number of nephropathic patients in this study is small, these conclusions must be interpreted with caution.

AB - OBJECTIVE: Patients with insulin-dependent diabetes mellitus (IDDM) have a high risk of developing diabetic nephropathy, retinopathy and cardiovascular diseases. The contribution of gene polymorphisms of the renin angiotensin system to these complications is controversial and may differ among populations.METHODS: In 257 Dutch IDDM patients (188 with urinary albumin excretion (UAE) <30 mg/24 h), logistic regression analysis was used to study the relationships among, on the one hand, the insertion/deletion gene polymorphism of the angiotensin-converting enzyme gene (ACE-ID), the M235T gene polymorphism of the angiotensinogen gene (AGT-M235T), and the A1166C gene polymorphism of the angiotensin type 1 receptor gene (AT1-A1166C), and, on the other hand, UAE, retinopathy, hypertension, and coronary heart disease.RESULTS: The T-allele of the AGT-M235T polymorphism was associated with an increased risk of an elevated UAE (odds ratio (OR) 3.03; 95% confidence interval (CI) 1.06-8.61), but only when interaction with the D-allele of the ACE-ID polymorphism was considered. A previously described positive interaction between the T-allele of the AGT-M235T polymorphism and the D-allele of the ACE-ID polymorphism could not be confirmed. The T-allele was also associated with an increased risk of retinopathy (OR 3.89, 95% CI 1.79-8.47). The CC-genotype of the AT1-A1166C polymorphism was associated with hypertension (OR 3.58; 95% CI 1. 23-10.37).CONCLUSIONS: In a Dutch IDDM population, including 69 patients with (incipient) diabetic nephropathy, the T-allele of the AGT-M235T polymorphism is associated with an elevated UAE and diabetic retinopathy and the CC-genotype of the AT1-A1166C polymorphism is associated with hypertension. A previously described interaction between the AGT-M235T and the ACE-ID polymorphisms could not be confirmed. Since the number of nephropathic patients in this study is small, these conclusions must be interpreted with caution.

KW - Adult

KW - Aged

KW - Albuminuria

KW - Angiotensinogen

KW - Coronary Disease

KW - DNA Transposable Elements

KW - Diabetes Mellitus, Type 1

KW - Diabetic Angiopathies

KW - Diabetic Nephropathies

KW - Diabetic Retinopathy

KW - Gene Deletion

KW - Humans

KW - Hypertension

KW - Middle Aged

KW - Peptidyl-Dipeptidase A

KW - Polymorphism, Genetic

KW - Receptor, Angiotensin, Type 1

KW - Receptor, Angiotensin, Type 2

KW - Receptors, Angiotensin

KW - Renin-Angiotensin System

KW - Journal Article

M3 - Journal article

C2 - 10862638

SN - 0931-0509

VL - 15

SP - 1000

EP - 1007

JO - Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

JF - Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

IS - 7

ER -

Genetic polymorphisms of the renin-angiotensin system and complications of insulin-dependent diabetes mellitus

Abstract

Fingeraftryk

Citationsformater