Genetic modifiers of menopausal hormone replacement therapy and breast cancer risk: a genome-wide interaction study

Anja Rudolph; Rebecca Hein; Sara Lindström; Lars Beckmann; Sabine Behrens; Jianjun Liu; Hugues Aschard; Manjeet K Bolla; Jean Wang; Thérèse Truong; Emilie Cordina-Duverger; Florence Menegaux; Thomas Brüning; Volker Harth; Gianluca Severi; Laura Baglietto; Melissa Southey; Stephen J Chanock; Jolanta Lissowska; Jonine D Figueroa; Mikael Eriksson; Keith Humpreys; Hatef Darabi; Janet E Olson; Kristen N Stevens; Celine M Vachon; Julia A Knight; Gord Glendon; Anna Marie Mulligan; Alan Ashworth; Nicholas Orr; Minouk Schoemaker; Penny M Webb; Pascal Guénel; Hiltrud Brauch; Graham Giles; Montserrat García-Closas; Kamila Czene; Georgia Chenevix-Trench; Fergus J Couch; Irene L Andrulis; Anthony Swerdlow; David J Hunter; Dieter Flesch-Janys; Douglas F Easton; Per Hall; Heli Nevanlinna; Peter Kraft; Jenny Chang-Claude; GENICA Network

doi:10.1530/ERC-13-0349

Genetic modifiers of menopausal hormone replacement therapy and breast cancer risk: a genome-wide interaction study

Anja Rudolph, Rebecca Hein, Sara Lindström, Lars Beckmann, Sabine Behrens, Jianjun Liu, Hugues Aschard, Manjeet K Bolla, Jean Wang, Thérèse Truong, Emilie Cordina-Duverger, Florence Menegaux, Thomas Brüning, Volker Harth, Gianluca Severi, Laura Baglietto, Melissa Southey, Stephen J Chanock, Jolanta Lissowska, Jonine D FigueroaMikael Eriksson, Keith Humpreys, Hatef Darabi, Janet E Olson, Kristen N Stevens, Celine M Vachon, Julia A Knight, Gord Glendon, Anna Marie Mulligan, Alan Ashworth, Nicholas Orr, Minouk Schoemaker, Penny M Webb, Pascal Guénel, Hiltrud Brauch, Graham Giles, Montserrat García-Closas, Kamila Czene, Georgia Chenevix-Trench, Fergus J Couch, Irene L Andrulis, Anthony Swerdlow, David J Hunter, Dieter Flesch-Janys, Douglas F Easton, Per Hall, Heli Nevanlinna, Peter Kraft, Jenny Chang-Claude, GENICA Network

25 Citationer (Scopus)

Abstract

Women using menopausal hormone therapy (MHT) are at increased risk of developing breast cancer (BC). To detect genetic modifiers of the association between current use of MHT and BC risk, we conducted a meta-analysis of four genome-wide case-only studies followed by replication in 11 case-control studies. We used a case-only design to assess interactions between single-nucleotide polymorphisms (SNPs) and current MHT use on risk of overall and lobular BC. The discovery stage included 2920 cases (541 lobular) from four genome-wide association studies. The top 1391 SNPs showing P values for interaction (Pint)

Originalsprog	Engelsk
Tidsskrift	Endocrine - Related Cancer
Vol/bind	20
Udgave nummer	6
Sider (fra-til)	875-87
Antal sider	13
ISSN	1351-0088
DOI	https://doi.org/10.1530/ERC-13-0349
Status	Udgivet - dec. 2013

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10.1530/ERC-13-0349

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Rudolph, A., Hein, R., Lindström, S., Beckmann, L., Behrens, S., Liu, J., Aschard, H., Bolla, M. K., Wang, J., Truong, T., Cordina-Duverger, E., Menegaux, F., Brüning, T., Harth, V., Severi, G., Baglietto, L., Southey, M., Chanock, S. J., Lissowska, J., ... GENICA Network (2013). Genetic modifiers of menopausal hormone replacement therapy and breast cancer risk: a genome-wide interaction study. Endocrine - Related Cancer, 20(6), 875-87. https://doi.org/10.1530/ERC-13-0349

Rudolph, A, Hein, R, Lindström, S, Beckmann, L, Behrens, S, Liu, J, Aschard, H, Bolla, MK, Wang, J, Truong, T, Cordina-Duverger, E, Menegaux, F, Brüning, T, Harth, V, Severi, G, Baglietto, L, Southey, M, Chanock, SJ, Lissowska, J, Figueroa, JD, Eriksson, M, Humpreys, K, Darabi, H, Olson, JE, Stevens, KN, Vachon, CM, Knight, JA, Glendon, G, Mulligan, AM, Ashworth, A, Orr, N, Schoemaker, M, Webb, PM, Guénel, P, Brauch, H, Giles, G, García-Closas, M, Czene, K, Chenevix-Trench, G, Couch, FJ, Andrulis, IL, Swerdlow, A, Hunter, DJ, Flesch-Janys, D, Easton, DF, Hall, P, Nevanlinna, H, Kraft, P, Chang-Claude, J & GENICA Network 2013, 'Genetic modifiers of menopausal hormone replacement therapy and breast cancer risk: a genome-wide interaction study', Endocrine - Related Cancer, bind 20, nr. 6, s. 875-87. https://doi.org/10.1530/ERC-13-0349

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title = "Genetic modifiers of menopausal hormone replacement therapy and breast cancer risk: a genome-wide interaction study",

abstract = "Women using menopausal hormone therapy (MHT) are at increased risk of developing breast cancer (BC). To detect genetic modifiers of the association between current use of MHT and BC risk, we conducted a meta-analysis of four genome-wide case-only studies followed by replication in 11 case-control studies. We used a case-only design to assess interactions between single-nucleotide polymorphisms (SNPs) and current MHT use on risk of overall and lobular BC. The discovery stage included 2920 cases (541 lobular) from four genome-wide association studies. The top 1391 SNPs showing P values for interaction (Pint) ",

author = "Anja Rudolph and Rebecca Hein and Sara Lindstr{\"o}m and Lars Beckmann and Sabine Behrens and Jianjun Liu and Hugues Aschard and Bolla, {Manjeet K} and Jean Wang and Th{\'e}r{\`e}se Truong and Emilie Cordina-Duverger and Florence Menegaux and Thomas Br{\"u}ning and Volker Harth and Gianluca Severi and Laura Baglietto and Melissa Southey and Chanock, {Stephen J} and Jolanta Lissowska and Figueroa, {Jonine D} and Mikael Eriksson and Keith Humpreys and Hatef Darabi and Olson, {Janet E} and Stevens, {Kristen N} and Vachon, {Celine M} and Knight, {Julia A} and Gord Glendon and Mulligan, {Anna Marie} and Alan Ashworth and Nicholas Orr and Minouk Schoemaker and Webb, {Penny M} and Pascal Gu{\'e}nel and Hiltrud Brauch and Graham Giles and Montserrat Garc{\'i}a-Closas and Kamila Czene and Georgia Chenevix-Trench and Couch, {Fergus J} and Andrulis, {Irene L} and Anthony Swerdlow and Hunter, {David J} and Dieter Flesch-Janys and Easton, {Douglas F} and Per Hall and Heli Nevanlinna and Peter Kraft and Jenny Chang-Claude and {GENICA Network} and Nordestgaard, {B{\o}rge G.}",

year = "2013",

month = dec,

doi = "10.1530/ERC-13-0349",

language = "English",

volume = "20",

pages = "875--87",

journal = "Endocrine - Related Cancer",

issn = "1351-0088",

publisher = "Society for Endocrinology",

number = "6",

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TY - JOUR

T1 - Genetic modifiers of menopausal hormone replacement therapy and breast cancer risk

T2 - a genome-wide interaction study

AU - Rudolph, Anja

AU - Hein, Rebecca

AU - Lindström, Sara

AU - Beckmann, Lars

AU - Behrens, Sabine

AU - Liu, Jianjun

AU - Aschard, Hugues

AU - Bolla, Manjeet K

AU - Wang, Jean

AU - Truong, Thérèse

AU - Cordina-Duverger, Emilie

AU - Menegaux, Florence

AU - Brüning, Thomas

AU - Harth, Volker

AU - Severi, Gianluca

AU - Baglietto, Laura

AU - Southey, Melissa

AU - Chanock, Stephen J

AU - Lissowska, Jolanta

AU - Figueroa, Jonine D

AU - Eriksson, Mikael

AU - Humpreys, Keith

AU - Darabi, Hatef

AU - Olson, Janet E

AU - Stevens, Kristen N

AU - Vachon, Celine M

AU - Knight, Julia A

AU - Glendon, Gord

AU - Mulligan, Anna Marie

AU - Ashworth, Alan

AU - Orr, Nicholas

AU - Schoemaker, Minouk

AU - Webb, Penny M

AU - Guénel, Pascal

AU - Brauch, Hiltrud

AU - Giles, Graham

AU - García-Closas, Montserrat

AU - Czene, Kamila

AU - Chenevix-Trench, Georgia

AU - Couch, Fergus J

AU - Andrulis, Irene L

AU - Swerdlow, Anthony

AU - Hunter, David J

AU - Flesch-Janys, Dieter

AU - Easton, Douglas F

AU - Hall, Per

AU - Nevanlinna, Heli

AU - Kraft, Peter

AU - Chang-Claude, Jenny

AU - GENICA Network

AU - Nordestgaard, Børge G.

PY - 2013/12

Y1 - 2013/12

N2 - Women using menopausal hormone therapy (MHT) are at increased risk of developing breast cancer (BC). To detect genetic modifiers of the association between current use of MHT and BC risk, we conducted a meta-analysis of four genome-wide case-only studies followed by replication in 11 case-control studies. We used a case-only design to assess interactions between single-nucleotide polymorphisms (SNPs) and current MHT use on risk of overall and lobular BC. The discovery stage included 2920 cases (541 lobular) from four genome-wide association studies. The top 1391 SNPs showing P values for interaction (Pint)

AB - Women using menopausal hormone therapy (MHT) are at increased risk of developing breast cancer (BC). To detect genetic modifiers of the association between current use of MHT and BC risk, we conducted a meta-analysis of four genome-wide case-only studies followed by replication in 11 case-control studies. We used a case-only design to assess interactions between single-nucleotide polymorphisms (SNPs) and current MHT use on risk of overall and lobular BC. The discovery stage included 2920 cases (541 lobular) from four genome-wide association studies. The top 1391 SNPs showing P values for interaction (Pint)

U2 - 10.1530/ERC-13-0349

DO - 10.1530/ERC-13-0349

M3 - Journal article

C2 - 24080446

SN - 1351-0088

VL - 20

SP - 875

EP - 887

JO - Endocrine - Related Cancer

JF - Endocrine - Related Cancer

IS - 6

ER -

Genetic modifiers of menopausal hormone replacement therapy and breast cancer risk: a genome-wide interaction study

Abstract

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