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Genetic influence on the associations between IGF-I and glucose metabolism in a cohort of elderly twins

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Jensen, Rikke Beck ; Thankamony, Ajay ; Holst, Klaus K ; Janssen, Joseph A M J L ; Juul, Anders ; Dunger, David ; Poulsen, Pernille ; Scheike, Thomas. / Genetic influence on the associations between IGF-I and glucose metabolism in a cohort of elderly twins. I: European Journal of Endocrinology. 2018 ; Bind 178, Nr. 2. s. 155-163.

Bibtex

@article{cd7027142d06483189f8dd7571011331,
title = "Genetic influence on the associations between IGF-I and glucose metabolism in a cohort of elderly twins",
abstract = "OBJECTIVE: IGF-I may be a marker of later metabolic and cardiovascular disease. The interactions between IGF-I and glucose metabolism are multifactorial, and there is potential confounding from several secondary effects. In this study, we examined the interaction between IGF-I and glucose metabolism in a large cohort of clinically well-characterized elderly twins.DESIGN: A total of 303 twin pairs of the same gender (606 twins) were included in the study; 125 monozygotic and 178 dizygotic twin pairs.METHODS: A clinical examination including a standard oral glucose tolerance test (OGTT) and anthropometric measurements was performed.RESULTS: The heritability estimates were high for IGF-I and IGFBP-3 (h2: 0.65 (95{\%} CI: 0.55-0.74) and 0.71 (0.48-0.94), respectively) and for insulin secretion (h2 = 0.56, P < 0.0001), whereas the heritability estimates for insulin sensitivity were low (h2 = 0.14, P = 0.11). In a multiple regression analysis (adjusting for age, gender and twin status), there was a negative association between IGF-I and insulin sensitivity (B: -0.13, SE 0.03, P < 0.0001) and IGF-I and disposition index (B: -0.05, SE 0.02, P < 0.001) in the entire cohort of 606 twins. The associations between IGF-I and both DI and HOMA-S did not differ between the DZ and MZ twins. Forty-five twin pairs were discordant for T2D, but the discordant twins had similar concentrations of IGF-I or IGFBP-3.CONCLUSIONS: There was a high heritability for IGF-I and IGFBP-3, but a low heritability for insulin secretion and insulin sensitivity in a group of elderly twins. In addition, we found a strong negative relationship between IGF-I and insulin sensitivity, which did not seem to be strongly genetically determined.",
keywords = "Aged, Anthropometry, Blood Glucose/metabolism, Cohort Studies, Denmark, Diabetes Mellitus, Type 2/genetics, Diseases in Twins/genetics, Female, Glucose Tolerance Test, Humans, Insulin/metabolism, Insulin Resistance/genetics, Insulin Secretion, Insulin-Like Growth Factor Binding Protein 3/metabolism, Insulin-Like Growth Factor I/metabolism, Linear Models, Male, Middle Aged, Twins, Dizygotic, Twins, Monozygotic",
author = "Jensen, {Rikke Beck} and Ajay Thankamony and Holst, {Klaus K} and Janssen, {Joseph A M J L} and Anders Juul and David Dunger and Pernille Poulsen and Thomas Scheike",
note = "{\circledC} 2018 European Society of Endocrinology.",
year = "2018",
month = "2",
doi = "10.1530/EJE-17-0754",
language = "English",
volume = "178",
pages = "155--163",
journal = "European Journal of Endocrinology",
issn = "0804-4643",
publisher = "BioScientifica Ltd",
number = "2",

}

RIS

TY - JOUR

T1 - Genetic influence on the associations between IGF-I and glucose metabolism in a cohort of elderly twins

AU - Jensen, Rikke Beck

AU - Thankamony, Ajay

AU - Holst, Klaus K

AU - Janssen, Joseph A M J L

AU - Juul, Anders

AU - Dunger, David

AU - Poulsen, Pernille

AU - Scheike, Thomas

N1 - © 2018 European Society of Endocrinology.

PY - 2018/2

Y1 - 2018/2

N2 - OBJECTIVE: IGF-I may be a marker of later metabolic and cardiovascular disease. The interactions between IGF-I and glucose metabolism are multifactorial, and there is potential confounding from several secondary effects. In this study, we examined the interaction between IGF-I and glucose metabolism in a large cohort of clinically well-characterized elderly twins.DESIGN: A total of 303 twin pairs of the same gender (606 twins) were included in the study; 125 monozygotic and 178 dizygotic twin pairs.METHODS: A clinical examination including a standard oral glucose tolerance test (OGTT) and anthropometric measurements was performed.RESULTS: The heritability estimates were high for IGF-I and IGFBP-3 (h2: 0.65 (95% CI: 0.55-0.74) and 0.71 (0.48-0.94), respectively) and for insulin secretion (h2 = 0.56, P < 0.0001), whereas the heritability estimates for insulin sensitivity were low (h2 = 0.14, P = 0.11). In a multiple regression analysis (adjusting for age, gender and twin status), there was a negative association between IGF-I and insulin sensitivity (B: -0.13, SE 0.03, P < 0.0001) and IGF-I and disposition index (B: -0.05, SE 0.02, P < 0.001) in the entire cohort of 606 twins. The associations between IGF-I and both DI and HOMA-S did not differ between the DZ and MZ twins. Forty-five twin pairs were discordant for T2D, but the discordant twins had similar concentrations of IGF-I or IGFBP-3.CONCLUSIONS: There was a high heritability for IGF-I and IGFBP-3, but a low heritability for insulin secretion and insulin sensitivity in a group of elderly twins. In addition, we found a strong negative relationship between IGF-I and insulin sensitivity, which did not seem to be strongly genetically determined.

AB - OBJECTIVE: IGF-I may be a marker of later metabolic and cardiovascular disease. The interactions between IGF-I and glucose metabolism are multifactorial, and there is potential confounding from several secondary effects. In this study, we examined the interaction between IGF-I and glucose metabolism in a large cohort of clinically well-characterized elderly twins.DESIGN: A total of 303 twin pairs of the same gender (606 twins) were included in the study; 125 monozygotic and 178 dizygotic twin pairs.METHODS: A clinical examination including a standard oral glucose tolerance test (OGTT) and anthropometric measurements was performed.RESULTS: The heritability estimates were high for IGF-I and IGFBP-3 (h2: 0.65 (95% CI: 0.55-0.74) and 0.71 (0.48-0.94), respectively) and for insulin secretion (h2 = 0.56, P < 0.0001), whereas the heritability estimates for insulin sensitivity were low (h2 = 0.14, P = 0.11). In a multiple regression analysis (adjusting for age, gender and twin status), there was a negative association between IGF-I and insulin sensitivity (B: -0.13, SE 0.03, P < 0.0001) and IGF-I and disposition index (B: -0.05, SE 0.02, P < 0.001) in the entire cohort of 606 twins. The associations between IGF-I and both DI and HOMA-S did not differ between the DZ and MZ twins. Forty-five twin pairs were discordant for T2D, but the discordant twins had similar concentrations of IGF-I or IGFBP-3.CONCLUSIONS: There was a high heritability for IGF-I and IGFBP-3, but a low heritability for insulin secretion and insulin sensitivity in a group of elderly twins. In addition, we found a strong negative relationship between IGF-I and insulin sensitivity, which did not seem to be strongly genetically determined.

KW - Aged

KW - Anthropometry

KW - Blood Glucose/metabolism

KW - Cohort Studies

KW - Denmark

KW - Diabetes Mellitus, Type 2/genetics

KW - Diseases in Twins/genetics

KW - Female

KW - Glucose Tolerance Test

KW - Humans

KW - Insulin/metabolism

KW - Insulin Resistance/genetics

KW - Insulin Secretion

KW - Insulin-Like Growth Factor Binding Protein 3/metabolism

KW - Insulin-Like Growth Factor I/metabolism

KW - Linear Models

KW - Male

KW - Middle Aged

KW - Twins, Dizygotic

KW - Twins, Monozygotic

U2 - 10.1530/EJE-17-0754

DO - 10.1530/EJE-17-0754

M3 - Journal article

VL - 178

SP - 155

EP - 163

JO - European Journal of Endocrinology

JF - European Journal of Endocrinology

SN - 0804-4643

IS - 2

ER -

ID: 56482813