Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Genetic Determinants of Weight Loss After Bariatric Surgery

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Plasma FGF-19 Levels are Increased in Patients with Post-Bariatric Hypoglycemia

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Bone health in patients with type 2 diabetes treated by Roux-En-Y gastric bypass and the role of diabetes remission

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. The Impact of Upper Abdominal Pain During Pregnancy Following a Gastric Bypass

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Vagal Blocking for Obesity Control: a Possible Mechanism-Of-Action

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Investigating Intestinal Glucagon after Roux-en-Y Gastric Bypass Surgery

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Abdominal adiposity and cardiometabolic risk factors in children and adolescents: a Mendelian randomization analysis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

BACKGROUND: The weight loss after bariatric surgery shows considerable individual variation. Twin studies of response to dietary interventions and studies of bariatric surgery patients suggest that genetic differences may play a role. This study aimed to examine the effect of three genetic risk scores on the inter-individual variation in excess body mass index loss (EBMIL) after Roux-en-Y gastric bypass. Furthermore, we searched among known adiposity-related single nucleotide polymorphisms (SNPs) for genetic determinants of the inter-individual variation in EBMIL.

METHODS: Patients with morbid obesity underwent Roux-en-Y gastric bypass and were genotyped (n = 577). Two genetic risk scores for weight loss after bariatric surgery and a genetic risk score for body mass index were calculated. Associations between the genetic risk scores and EBMIL were evaluated. Lasso regression was performed on 126 SNPs known to be associated with adiposity.

RESULTS: The average EBMIL was 76.9% (range 21.7-149.2%). EBMIL was 81.1% (SD 20.6) and 73.9% (SD 21.7) in the high and low tertile groups of a genetic risk score for weight loss. Patients with a low genetic risk score for body mass index (in the lowest 5% percentile) had an EBMIL of 68.8% (SD 20.6, p = 0.018). Thirteen adiposity-related SNPs were identified to associate with EBMIL through lasso regression.

DISCUSSION: A genetic risk score was associated with EBMIL after bariatric surgery, but may not yet be applicable to clinical practice. Patients genetically predisposed to low body mass index had lower weight loss after bariatric surgery.

OriginalsprogEngelsk
TidsskriftObesity Surgery
Vol/bind29
Udgave nummer8
Sider (fra-til)2554-2561
Antal sider8
ISSN0960-8923
DOI
StatusUdgivet - aug. 2019

ID: 57016872