Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Genetic Determinants of Weight Loss After Bariatric Surgery

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Gastric Aspiration Improves Postprandial Glucose Tolerance Without Causing a Compensatory Increase in Appetite and Food Intake

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. The Effect of Bariatric Surgery on Healthcare Costs and Labor Market Attachment

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Bariatric Surgery and Risk of Unemployment and Sickness Absence

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Factors associated with favorable changes in food preferences after bariatric surgery

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Randomized Controlled Trial of Tesomet for Weight Loss in Hypothalamic Obesity

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Effect of Meal Texture on Postprandial Glucose Excursions and Gut Hormones After Roux-en-Y Gastric Bypass and Sleeve Gastrectomy

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. The Effect of Bariatric Surgery on Healthcare Costs and Labor Market Attachment

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. A genome-wide meta-analysis identifies 50 genetic loci associated with carpal tunnel syndrome

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Recessive Genome-wide Meta-analysis Illuminates Genetic Architecture of Type 2 Diabetes

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

BACKGROUND: The weight loss after bariatric surgery shows considerable individual variation. Twin studies of response to dietary interventions and studies of bariatric surgery patients suggest that genetic differences may play a role. This study aimed to examine the effect of three genetic risk scores on the inter-individual variation in excess body mass index loss (EBMIL) after Roux-en-Y gastric bypass. Furthermore, we searched among known adiposity-related single nucleotide polymorphisms (SNPs) for genetic determinants of the inter-individual variation in EBMIL.

METHODS: Patients with morbid obesity underwent Roux-en-Y gastric bypass and were genotyped (n = 577). Two genetic risk scores for weight loss after bariatric surgery and a genetic risk score for body mass index were calculated. Associations between the genetic risk scores and EBMIL were evaluated. Lasso regression was performed on 126 SNPs known to be associated with adiposity.

RESULTS: The average EBMIL was 76.9% (range 21.7-149.2%). EBMIL was 81.1% (SD 20.6) and 73.9% (SD 21.7) in the high and low tertile groups of a genetic risk score for weight loss. Patients with a low genetic risk score for body mass index (in the lowest 5% percentile) had an EBMIL of 68.8% (SD 20.6, p = 0.018). Thirteen adiposity-related SNPs were identified to associate with EBMIL through lasso regression.

DISCUSSION: A genetic risk score was associated with EBMIL after bariatric surgery, but may not yet be applicable to clinical practice. Patients genetically predisposed to low body mass index had lower weight loss after bariatric surgery.

OriginalsprogEngelsk
TidsskriftObesity Surgery
Vol/bind29
Udgave nummer8
Sider (fra-til)2554-2561
Antal sider8
ISSN0960-8923
DOI
StatusUdgivet - aug. 2019

ID: 57016872