TY - JOUR
T1 - Genetic determinants of both ethanol and acetaldehyde metabolism influence alcohol hypersensitivity and drinking behaviour among Scandinavians
AU - Linneberg, A
AU - Gonzalez-Quintela, A
AU - Vidal, C
AU - Jørgensen, T
AU - Fenger, M
AU - Hansen, T
AU - Pedersen, O
AU - Husemoen, Lise-Lotte
PY - 2010/1/1
Y1 - 2010/1/1
N2 - Although hypersensitivity reactions following intake of alcoholic drinks are common in Caucasians, the underlying mechanisms and clinical significance are not known. In contrast, in Asians, alcohol-induced asthma and flushing have been shown to be because of a single nucleotide polymorphism (SNP), the acetaldehyde dehydrogenase 2 (ALDH2) 487lys, causing decreased acetaldehyde (the metabolite of ethanol) metabolism and high levels of histamine. However, the ALDH2 487lys is absent in Caucasians.
AB - Although hypersensitivity reactions following intake of alcoholic drinks are common in Caucasians, the underlying mechanisms and clinical significance are not known. In contrast, in Asians, alcohol-induced asthma and flushing have been shown to be because of a single nucleotide polymorphism (SNP), the acetaldehyde dehydrogenase 2 (ALDH2) 487lys, causing decreased acetaldehyde (the metabolite of ethanol) metabolism and high levels of histamine. However, the ALDH2 487lys is absent in Caucasians.
U2 - 10.1111/j.1365-2222.2009.03398.x
DO - 10.1111/j.1365-2222.2009.03398.x
M3 - Journal article
C2 - 20205700
SN - 1365-2222
VL - 40
SP - 123
EP - 130
JO - Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
JF - Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
IS - 1
ER -