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Genetic correlation between amyotrophic lateral sclerosis and schizophrenia

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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  • Russell L McLaughlin
  • Dick Schijven
  • Wouter van Rheenen
  • Kristel R van Eijk
  • Margaret O'Brien
  • René S Kahn
  • Roel A Ophoff
  • An Goris
  • Daniel G Bradley
  • Ammar Al-Chalabi
  • Leonard H van den Berg
  • Jurjen J Luykx
  • Orla Hardiman
  • Jan H Veldink
  • Project MinE GWAS Consortium
  • Thomas Mears Werge (Medlem af forfattergruppering)
  • Henrik Berg Rasmussen (Medlem af forfattergruppering)
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We have previously shown higher-than-expected rates of schizophrenia in relatives of patients with amyotrophic lateral sclerosis (ALS), suggesting an aetiological relationship between the diseases. Here, we investigate the genetic relationship between ALS and schizophrenia using genome-wide association study data from over 100,000 unique individuals. Using linkage disequilibrium score regression, we estimate the genetic correlation between ALS and schizophrenia to be 14.3% (7.05-21.6; P=1 × 10-4) with schizophrenia polygenic risk scores explaining up to 0.12% of the variance in ALS (P=8.4 × 10-7). A modest increase in comorbidity of ALS and schizophrenia is expected given these findings (odds ratio 1.08-1.26) but this would require very large studies to observe epidemiologically. We identify five potential novel ALS-associated loci using conditional false discovery rate analysis. It is likely that shared neurobiological mechanisms between these two disorders will engender novel hypotheses in future preclinical and clinical studies.

OriginalsprogEngelsk
TidsskriftNature Communications
Vol/bind8
Sider (fra-til)14774
ISSN2041-1723
DOI
StatusUdgivet - 21 mar. 2017

ID: 52695015