TY - JOUR
T1 - Genetic Biomarkers in Melanoma of the Ocular Region
T2 - What the Medical Oncologist Should Know
AU - Bol, Kalijn Fredrike
AU - Donia, Marco
AU - Heegaard, Steffen
AU - Kiilgaard, Jens Folke
AU - Svane, Inge Marie
PY - 2020/7/23
Y1 - 2020/7/23
N2 - Melanoma of the ocular region (ocular melanoma) comprises about 5% of all patients with melanoma and covers posterior uveal melanoma, iris melanoma, and conjunctival melanoma. The risk of metastasis is much higher in patients with ocular melanoma compared to a primary melanoma of the skin. The subtypes of ocular melanoma have distinct genetic features, which should be taken into consideration when making clinical decisions. Most relevant for current practice is the absence of BRAF mutations in posterior uveal melanoma, although present in some iris melanomas and conjunctival melanomas. In this review, we discuss the genetic biomarkers of the subtypes of ocular melanoma and their impacts on the clinical care of these patients.
AB - Melanoma of the ocular region (ocular melanoma) comprises about 5% of all patients with melanoma and covers posterior uveal melanoma, iris melanoma, and conjunctival melanoma. The risk of metastasis is much higher in patients with ocular melanoma compared to a primary melanoma of the skin. The subtypes of ocular melanoma have distinct genetic features, which should be taken into consideration when making clinical decisions. Most relevant for current practice is the absence of BRAF mutations in posterior uveal melanoma, although present in some iris melanomas and conjunctival melanomas. In this review, we discuss the genetic biomarkers of the subtypes of ocular melanoma and their impacts on the clinical care of these patients.
KW - posterior uveal melanoma
KW - iris melanoma
KW - conjunctival melanoma
KW - ocular melanoma
KW - genetic biomarkers
KW - BRAFmutation
U2 - 10.3390/ijms21155231
DO - 10.3390/ijms21155231
M3 - Review
C2 - 32718045
VL - 21
SP - 5231
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
SN - 1661-6596
IS - 15
ER -