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Genetic Biomarkers in Melanoma of the Ocular Region: What the Medical Oncologist Should Know

Publikation: Bidrag til tidsskriftReviewForskningpeer review

DOI

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Vis graf over relationer

Melanoma of the ocular region (ocular melanoma) comprises about 5% of all patients with melanoma and covers posterior uveal melanoma, iris melanoma, and conjunctival melanoma. The risk of metastasis is much higher in patients with ocular melanoma compared to a primary melanoma of the skin. The subtypes of ocular melanoma have distinct genetic features, which should be taken into consideration when making clinical decisions. Most relevant for current practice is the absence of BRAF mutations in posterior uveal melanoma, although present in some iris melanomas and conjunctival melanomas. In this review, we discuss the genetic biomarkers of the subtypes of ocular melanoma and their impacts on the clinical care of these patients.

OriginalsprogEngelsk
TidsskriftInternational Journal of Molecular Sciences
Vol/bind21
Udgave nummer15
ISSN1661-6596
DOI
StatusUdgivet - 23 jul. 2020

ID: 61243800