Genetic background determines the size and structure of the endocrine pancreas

Troels Bock, Bente Pakkenberg, Karsten Buschard

74 Citationer (Scopus)

Abstract

Key parameters of the endocrine pancreas, such as islet number, islet mass, beta-cell mass, and alpha-cell mass, were studied in different strains of inbred mice to investigate the impact of genetic background on the size and structure of the endocrine pancreas. Six mice from each of seven different strains of inbred mice were included in the study. For all parameters investigated, there was a pronounced interstrain variation. ANCOVA showed that only mouse strain was statistically significant as an explanatory parameter for the number of islets. Mouse strain, body weight, and pancreas mass reached statistical significance as explanatory parameters for the islet mass, with mouse strain as the most significant predictor. These data show that genetic background is the most important predictor of both the number of islets and total islet volume. We also conclude that inbred mice could be a valuable resource to identify the genes responsible for the size and structure of the endocrine pancreas.

OriginalsprogEngelsk
TidsskriftDiabetes
Vol/bind54
Udgave nummer1
Sider (fra-til)133-7
Antal sider5
ISSN0012-1797
DOI
StatusUdgivet - jan. 2005
Udgivet eksterntJa

Fingeraftryk

Dyk ned i forskningsemnerne om 'Genetic background determines the size and structure of the endocrine pancreas'. Sammen danner de et unikt fingeraftryk.

Citationsformater