Genetic associations with valvular calcification and aortic stenosis

George Thanassoulis; Catherine Y Campbell; David S Owens; J Gustav Smith; Albert V Smith; Gina M Peloso; Kathleen F Kerr; Sonali Pechlivanis; Matthew J Budoff; Tamara B Harris; Rajeev Malhotra; Kevin D O'Brien; Pia R Kamstrup; Børge G Nordestgaard; Anne Tybjaerg-Hansen; Matthew A Allison; Thor Aspelund; Michael H Criqui; Susan R Heckbert; Shih-Jen Hwang; Yongmei Liu; Marketa Sjogren; Jesper van der Pals; Hagen Kälsch; Thomas W Mühleisen; Markus M Nöthen; L Adrienne Cupples; Muriel Caslake; Emanuele Di Angelantonio; John Danesh; Jerome I Rotter; Sigurdur Sigurdsson; Quenna Wong; Raimund Erbel; Sekar Kathiresan; Olle Melander; Vilmundur Gudnason; Christopher J O'Donnell; Wendy S Post; CHARGE Extracoronary Calcium Working Group

doi:10.1056/NEJMoa1109034

Genetic associations with valvular calcification and aortic stenosis

George Thanassoulis, Catherine Y Campbell, David S Owens, J Gustav Smith, Albert V Smith, Gina M Peloso, Kathleen F Kerr, Sonali Pechlivanis, Matthew J Budoff, Tamara B Harris, Rajeev Malhotra, Kevin D O'Brien, Pia R Kamstrup, Børge G Nordestgaard, Anne Tybjaerg-Hansen, Matthew A Allison, Thor Aspelund, Michael H Criqui, Susan R Heckbert, Shih-Jen HwangYongmei Liu, Marketa Sjogren, Jesper van der Pals, Hagen Kälsch, Thomas W Mühleisen, Markus M Nöthen, L Adrienne Cupples, Muriel Caslake, Emanuele Di Angelantonio, John Danesh, Jerome I Rotter, Sigurdur Sigurdsson, Quenna Wong, Raimund Erbel, Sekar Kathiresan, Olle Melander, Vilmundur Gudnason, Christopher J O'Donnell, Wendy S Post, CHARGE Extracoronary Calcium Working Group

Afdeling for Klinisk Biokemi

798 Citationer (Scopus)

Abstract

Limited information is available regarding genetic contributions to valvular calcification, which is an important precursor of clinical valve disease.

Originalsprog	Engelsk
Tidsskrift	New England Journal of Medicine
Vol/bind	368
Udgave nummer	6
Sider (fra-til)	503-12
Antal sider	10
ISSN	0028-4793
DOI	https://doi.org/10.1056/NEJMoa1109034
Status	Udgivet - 7 feb. 2013

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10.1056/NEJMoa1109034

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Thanassoulis, G., Campbell, C. Y., Owens, D. S., Smith, J. G., Smith, A. V., Peloso, G. M., Kerr, K. F., Pechlivanis, S., Budoff, M. J., Harris, T. B., Malhotra, R., O'Brien, K. D., Kamstrup, P. R., Nordestgaard, B. G., Tybjaerg-Hansen, A., Allison, M. A., Aspelund, T., Criqui, M. H., Heckbert, S. R., ... CHARGE Extracoronary Calcium Working Group (2013). Genetic associations with valvular calcification and aortic stenosis. New England Journal of Medicine, 368(6), 503-12. https://doi.org/10.1056/NEJMoa1109034

Thanassoulis, G, Campbell, CY, Owens, DS, Smith, JG, Smith, AV, Peloso, GM, Kerr, KF, Pechlivanis, S, Budoff, MJ, Harris, TB, Malhotra, R, O'Brien, KD, Kamstrup, PR , Nordestgaard, BG , Tybjaerg-Hansen, A, Allison, MA, Aspelund, T, Criqui, MH, Heckbert, SR, Hwang, S-J, Liu, Y, Sjogren, M, van der Pals, J, Kälsch, H, Mühleisen, TW, Nöthen, MM, Cupples, LA, Caslake, M, Di Angelantonio, E, Danesh, J, Rotter, JI, Sigurdsson, S, Wong, Q, Erbel, R, Kathiresan, S, Melander, O, Gudnason, V, O'Donnell, CJ, Post, WS & CHARGE Extracoronary Calcium Working Group 2013, 'Genetic associations with valvular calcification and aortic stenosis', New England Journal of Medicine, bind 368, nr. 6, s. 503-12. https://doi.org/10.1056/NEJMoa1109034

@article{2880ef68c1dd485eb0b08cf5fdb93838,

title = "Genetic associations with valvular calcification and aortic stenosis",

abstract = "Limited information is available regarding genetic contributions to valvular calcification, which is an important precursor of clinical valve disease.",

keywords = "Aged, Aortic Valve, Aortic Valve Stenosis, Calcinosis, Female, Genome-Wide Association Study, Heart Valve Diseases, Humans, Linear Models, Lipoprotein(a), Male, Mendelian Randomization Analysis, Middle Aged, Mitral Valve, Polymorphism, Single Nucleotide, Tomography, X-Ray Computed",

author = "George Thanassoulis and Campbell, {Catherine Y} and Owens, {David S} and Smith, {J Gustav} and Smith, {Albert V} and Peloso, {Gina M} and Kerr, {Kathleen F} and Sonali Pechlivanis and Budoff, {Matthew J} and Harris, {Tamara B} and Rajeev Malhotra and O'Brien, {Kevin D} and Kamstrup, {Pia R} and Nordestgaard, {B{\o}rge G} and Anne Tybjaerg-Hansen and Allison, {Matthew A} and Thor Aspelund and Criqui, {Michael H} and Heckbert, {Susan R} and Shih-Jen Hwang and Yongmei Liu and Marketa Sjogren and {van der Pals}, Jesper and Hagen K{\"a}lsch and M{\"u}hleisen, {Thomas W} and N{\"o}then, {Markus M} and Cupples, {L Adrienne} and Muriel Caslake and {Di Angelantonio}, Emanuele and John Danesh and Rotter, {Jerome I} and Sigurdur Sigurdsson and Quenna Wong and Raimund Erbel and Sekar Kathiresan and Olle Melander and Vilmundur Gudnason and O'Donnell, {Christopher J} and Post, {Wendy S} and {CHARGE Extracoronary Calcium Working Group}",

year = "2013",

month = feb,

day = "7",

doi = "10.1056/NEJMoa1109034",

language = "English",

volume = "368",

pages = "503--12",

journal = "New England Journal of Medicine",

issn = "0028-4793",

publisher = "Massachussetts Medical Society",

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TY - JOUR

T1 - Genetic associations with valvular calcification and aortic stenosis

AU - Thanassoulis, George

AU - Campbell, Catherine Y

AU - Owens, David S

AU - Smith, J Gustav

AU - Smith, Albert V

AU - Peloso, Gina M

AU - Kerr, Kathleen F

AU - Pechlivanis, Sonali

AU - Budoff, Matthew J

AU - Harris, Tamara B

AU - Malhotra, Rajeev

AU - O'Brien, Kevin D

AU - Kamstrup, Pia R

AU - Nordestgaard, Børge G

AU - Tybjaerg-Hansen, Anne

AU - Allison, Matthew A

AU - Aspelund, Thor

AU - Criqui, Michael H

AU - Heckbert, Susan R

AU - Hwang, Shih-Jen

AU - Liu, Yongmei

AU - Sjogren, Marketa

AU - van der Pals, Jesper

AU - Kälsch, Hagen

AU - Mühleisen, Thomas W

AU - Nöthen, Markus M

AU - Cupples, L Adrienne

AU - Caslake, Muriel

AU - Di Angelantonio, Emanuele

AU - Danesh, John

AU - Rotter, Jerome I

AU - Sigurdsson, Sigurdur

AU - Wong, Quenna

AU - Erbel, Raimund

AU - Kathiresan, Sekar

AU - Melander, Olle

AU - Gudnason, Vilmundur

AU - O'Donnell, Christopher J

AU - Post, Wendy S

AU - CHARGE Extracoronary Calcium Working Group

PY - 2013/2/7

Y1 - 2013/2/7

N2 - Limited information is available regarding genetic contributions to valvular calcification, which is an important precursor of clinical valve disease.

AB - Limited information is available regarding genetic contributions to valvular calcification, which is an important precursor of clinical valve disease.

KW - Aged

KW - Aortic Valve

KW - Aortic Valve Stenosis

KW - Calcinosis

KW - Female

KW - Genome-Wide Association Study

KW - Heart Valve Diseases

KW - Humans

KW - Linear Models

KW - Lipoprotein(a)

KW - Male

KW - Mendelian Randomization Analysis

KW - Middle Aged

KW - Mitral Valve

KW - Polymorphism, Single Nucleotide

KW - Tomography, X-Ray Computed

U2 - 10.1056/NEJMoa1109034

DO - 10.1056/NEJMoa1109034

M3 - Journal article

C2 - 23388002

SN - 0028-4793

VL - 368

SP - 503

EP - 512

JO - New England Journal of Medicine

JF - New England Journal of Medicine

IS - 6

ER -

Genetic associations with valvular calcification and aortic stenosis

Abstract

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