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Genetic architecture of sporadic frontotemporal dementia and overlap with Alzheimer's and Parkinson's diseases

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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  • Raffaele Ferrari
  • Yunpeng Wang
  • Jana Vandrovcova
  • Sebastian Guelfi
  • Aree Witeolar
  • Celeste M Karch
  • Andrew J Schork
  • Chun C Fan
  • James B Brewer
  • Parastoo Momeni
  • Gerard D Schellenberg
  • William P Dillon
  • Leo P Sugrue
  • Christopher P Hess
  • Jennifer S Yokoyama
  • Luke W Bonham
  • Gil D Rabinovici
  • Bruce L Miller
  • Ole A Andreassen
  • Anders M Dale
  • John Hardy
  • Rahul S Desikan
  • International FTD-Genomics Consortium (IFGC),
  • Lena Elisabeth Hjermind (Medlem af forfattergruppering)
  • Jørgen Erik Nielsen (Medlem af forfattergruppering)
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BACKGROUND: Clinical, pathological and genetic overlap between sporadic frontotemporal dementia (FTD), Alzheimer's disease (AD) and Parkinson's disease (PD) has been suggested; however, the relationship between these disorders is still not well understood. Here we evaluated genetic overlap between FTD, AD and PD to assess shared pathobiology and identify novel genetic variants associated with increased risk for FTD.

METHODS: Summary statistics were obtained from the International FTD Genomics Consortium, International PD Genetics Consortium and International Genomics of AD Project (n>75 000 cases and controls). We used conjunction false discovery rate (FDR) to evaluate genetic pleiotropy and conditional FDR to identify novel FTD-associated SNPs. Relevant variants were further evaluated for expression quantitative loci.

RESULTS: We observed SNPs within the HLA, MAPT and APOE regions jointly contributing to increased risk for FTD and AD or PD. By conditioning on polymorphisms associated with PD and AD, we found 11 loci associated with increased risk for FTD. Meta-analysis across two independent FTD cohorts revealed a genome-wide signal within the APOE region (rs6857, 3'-UTR=PVRL2, p=2.21×10-12), and a suggestive signal for rs1358071 within the MAPT region (intronic=CRHR1, p=4.91×10-7) with the effect allele tagging the H1 haplotype. Pleiotropic SNPs at the HLA and MAPT loci associated with expression changes in cis-genes supporting involvement of intracellular vesicular trafficking, immune response and endo/lysosomal processes.

CONCLUSIONS: Our findings demonstrate genetic pleiotropy in these neurodegenerative diseases and indicate that sporadic FTD is a polygenic disorder where multiple pleiotropic loci with small effects contribute to increased disease risk.

OriginalsprogEngelsk
TidsskriftJournal of neurology, neurosurgery, and psychiatry
Vol/bind88
Udgave nummer2
Sider (fra-til)152-164
Antal sider13
ISSN0022-3050
DOI
StatusUdgivet - feb. 2017

ID: 52207111