Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Genetic and Functional Drivers of Diffuse Large B Cell Lymphoma

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Harvard

Reddy, A, Zhang, J, Davis, NS, Moffitt, AB, Love, CL, Waldrop, A, Leppa, S, Pasanen, A, Meriranta, L, Karjalainen-Lindsberg, M-L, Nørgaard, P, Pedersen, M, Gang, AO, Høgdall, E, Heavican, TB, Lone, W, Iqbal, J, Qin, Q, Li, G, Kim, SY, Healy, J, Richards, KL, Fedoriw, Y, Bernal-Mizrachi, L, Koff, JL, Staton, AD, Flowers, CR, Paltiel, O, Goldschmidt, N, Calaminici, M, Clear, A, Gribben, J, Nguyen, E, Czader, MB, Ondrejka, SL, Collie, A, Hsi, ED, Tse, E, Au-Yeung, RKH, Kwong, Y-L, Srivastava, G, Choi, WWL, Evens, AM, Pilichowska, M, Sengar, M, Reddy, N, Li, S, Chadburn, A, Gordon, LI, Jaffe, ES, Levy, S, Rempel, R, Tzeng, T, Happ, LE, Dave, T, Rajagopalan, D, Datta, J, Dunson, DB & Dave, SS 2017, 'Genetic and Functional Drivers of Diffuse Large B Cell Lymphoma' Cell, bind 171, nr. 2, s. 481-494.e15. https://doi.org/10.1016/j.cell.2017.09.027

APA

Reddy, A., Zhang, J., Davis, N. S., Moffitt, A. B., Love, C. L., Waldrop, A., ... Dave, S. S. (2017). Genetic and Functional Drivers of Diffuse Large B Cell Lymphoma. Cell, 171(2), 481-494.e15. https://doi.org/10.1016/j.cell.2017.09.027

CBE

Reddy A, Zhang J, Davis NS, Moffitt AB, Love CL, Waldrop A, Leppa S, Pasanen A, Meriranta L, Karjalainen-Lindsberg M-L, Nørgaard P, Pedersen M, Gang AO, Høgdall E, Heavican TB, Lone W, Iqbal J, Qin Q, Li G, Kim SY, Healy J, Richards KL, Fedoriw Y, Bernal-Mizrachi L, Koff JL, Staton AD, Flowers CR, Paltiel O, Goldschmidt N, Calaminici M, Clear A, Gribben J, Nguyen E, Czader MB, Ondrejka SL, Collie A, Hsi ED, Tse E, Au-Yeung RKH, Kwong Y-L, Srivastava G, Choi WWL, Evens AM, Pilichowska M, Sengar M, Reddy N, Li S, Chadburn A, Gordon LI, Jaffe ES, Levy S, Rempel R, Tzeng T, Happ LE, Dave T, Rajagopalan D, Datta J, Dunson DB, Dave SS. 2017. Genetic and Functional Drivers of Diffuse Large B Cell Lymphoma. Cell. 171(2):481-494.e15. https://doi.org/10.1016/j.cell.2017.09.027

MLA

Vancouver

Reddy A, Zhang J, Davis NS, Moffitt AB, Love CL, Waldrop A o.a. Genetic and Functional Drivers of Diffuse Large B Cell Lymphoma. Cell. 2017 okt 5;171(2):481-494.e15. https://doi.org/10.1016/j.cell.2017.09.027

Author

Reddy, Anupama ; Zhang, Jenny ; Davis, Nicholas S ; Moffitt, Andrea B ; Love, Cassandra L ; Waldrop, Alexander ; Leppa, Sirpa ; Pasanen, Annika ; Meriranta, Leo ; Karjalainen-Lindsberg, Marja-Liisa ; Nørgaard, Peter ; Pedersen, Mette ; Gang, Anne O ; Høgdall, Estrid ; Heavican, Tayla B ; Lone, Waseem ; Iqbal, Javeed ; Qin, Qiu ; Li, Guojie ; Kim, So Young ; Healy, Jane ; Richards, Kristy L ; Fedoriw, Yuri ; Bernal-Mizrachi, Leon ; Koff, Jean L ; Staton, Ashley D ; Flowers, Christopher R ; Paltiel, Ora ; Goldschmidt, Neta ; Calaminici, Maria ; Clear, Andrew ; Gribben, John ; Nguyen, Evelyn ; Czader, Magdalena B ; Ondrejka, Sarah L ; Collie, Angela ; Hsi, Eric D ; Tse, Eric ; Au-Yeung, Rex K H ; Kwong, Yok-Lam ; Srivastava, Gopesh ; Choi, William W L ; Evens, Andrew M ; Pilichowska, Monika ; Sengar, Manju ; Reddy, Nishitha ; Li, Shaoying ; Chadburn, Amy ; Gordon, Leo I ; Jaffe, Elaine S ; Levy, Shawn ; Rempel, Rachel ; Tzeng, Tiffany ; Happ, Lanie E ; Dave, Tushar ; Rajagopalan, Deepthi ; Datta, Jyotishka ; Dunson, David B ; Dave, Sandeep S. / Genetic and Functional Drivers of Diffuse Large B Cell Lymphoma. I: Cell. 2017 ; Bind 171, Nr. 2. s. 481-494.e15.

Bibtex

@article{3177d660b8cb4845bbf27009eefc9c60,
title = "Genetic and Functional Drivers of Diffuse Large B Cell Lymphoma",
abstract = "Diffuse large B cell lymphoma (DLBCL) is the most common form of blood cancer and is characterized by a striking degree of genetic and clinical heterogeneity. This heterogeneity poses a major barrier to understanding the genetic basis of the disease and its response to therapy. Here, we performed an integrative analysis of whole-exome sequencing and transcriptome sequencing in a cohort of 1,001 DLBCL patients to comprehensively define the landscape of 150 genetic drivers of the disease. We characterized the functional impact of these genes using an unbiased CRISPR screen of DLBCL cell lines to define oncogenes that promote cell growth. A prognostic model comprising these genetic alterations outperformed current established methods: cell of origin, the International Prognostic Index comprising clinical variables, and dual MYC and BCL2 expression. These results comprehensively define the genetic drivers and their functional roles in DLBCL to identify new therapeutic opportunities in the disease.",
keywords = "Antineoplastic Agents, CRISPR-Cas Systems, Cell Line, Tumor, Cells, Cultured, Exome, Female, Gene Expression Profiling, Humans, Lymphoma, Large B-Cell, Diffuse, Male, Rituximab, Journal Article",
author = "Anupama Reddy and Jenny Zhang and Davis, {Nicholas S} and Moffitt, {Andrea B} and Love, {Cassandra L} and Alexander Waldrop and Sirpa Leppa and Annika Pasanen and Leo Meriranta and Marja-Liisa Karjalainen-Lindsberg and Peter N{\o}rgaard and Mette Pedersen and Gang, {Anne O} and Estrid H{\o}gdall and Heavican, {Tayla B} and Waseem Lone and Javeed Iqbal and Qiu Qin and Guojie Li and Kim, {So Young} and Jane Healy and Richards, {Kristy L} and Yuri Fedoriw and Leon Bernal-Mizrachi and Koff, {Jean L} and Staton, {Ashley D} and Flowers, {Christopher R} and Ora Paltiel and Neta Goldschmidt and Maria Calaminici and Andrew Clear and John Gribben and Evelyn Nguyen and Czader, {Magdalena B} and Ondrejka, {Sarah L} and Angela Collie and Hsi, {Eric D} and Eric Tse and Au-Yeung, {Rex K H} and Yok-Lam Kwong and Gopesh Srivastava and Choi, {William W L} and Evens, {Andrew M} and Monika Pilichowska and Manju Sengar and Nishitha Reddy and Shaoying Li and Amy Chadburn and Gordon, {Leo I} and Jaffe, {Elaine S} and Shawn Levy and Rachel Rempel and Tiffany Tzeng and Happ, {Lanie E} and Tushar Dave and Deepthi Rajagopalan and Jyotishka Datta and Dunson, {David B} and Dave, {Sandeep S}",
note = "Copyright {\circledC} 2017 Elsevier Inc. All rights reserved.",
year = "2017",
month = "10",
day = "5",
doi = "10.1016/j.cell.2017.09.027",
language = "English",
volume = "171",
pages = "481--494.e15",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "2",

}

RIS

TY - JOUR

T1 - Genetic and Functional Drivers of Diffuse Large B Cell Lymphoma

AU - Reddy, Anupama

AU - Zhang, Jenny

AU - Davis, Nicholas S

AU - Moffitt, Andrea B

AU - Love, Cassandra L

AU - Waldrop, Alexander

AU - Leppa, Sirpa

AU - Pasanen, Annika

AU - Meriranta, Leo

AU - Karjalainen-Lindsberg, Marja-Liisa

AU - Nørgaard, Peter

AU - Pedersen, Mette

AU - Gang, Anne O

AU - Høgdall, Estrid

AU - Heavican, Tayla B

AU - Lone, Waseem

AU - Iqbal, Javeed

AU - Qin, Qiu

AU - Li, Guojie

AU - Kim, So Young

AU - Healy, Jane

AU - Richards, Kristy L

AU - Fedoriw, Yuri

AU - Bernal-Mizrachi, Leon

AU - Koff, Jean L

AU - Staton, Ashley D

AU - Flowers, Christopher R

AU - Paltiel, Ora

AU - Goldschmidt, Neta

AU - Calaminici, Maria

AU - Clear, Andrew

AU - Gribben, John

AU - Nguyen, Evelyn

AU - Czader, Magdalena B

AU - Ondrejka, Sarah L

AU - Collie, Angela

AU - Hsi, Eric D

AU - Tse, Eric

AU - Au-Yeung, Rex K H

AU - Kwong, Yok-Lam

AU - Srivastava, Gopesh

AU - Choi, William W L

AU - Evens, Andrew M

AU - Pilichowska, Monika

AU - Sengar, Manju

AU - Reddy, Nishitha

AU - Li, Shaoying

AU - Chadburn, Amy

AU - Gordon, Leo I

AU - Jaffe, Elaine S

AU - Levy, Shawn

AU - Rempel, Rachel

AU - Tzeng, Tiffany

AU - Happ, Lanie E

AU - Dave, Tushar

AU - Rajagopalan, Deepthi

AU - Datta, Jyotishka

AU - Dunson, David B

AU - Dave, Sandeep S

N1 - Copyright © 2017 Elsevier Inc. All rights reserved.

PY - 2017/10/5

Y1 - 2017/10/5

N2 - Diffuse large B cell lymphoma (DLBCL) is the most common form of blood cancer and is characterized by a striking degree of genetic and clinical heterogeneity. This heterogeneity poses a major barrier to understanding the genetic basis of the disease and its response to therapy. Here, we performed an integrative analysis of whole-exome sequencing and transcriptome sequencing in a cohort of 1,001 DLBCL patients to comprehensively define the landscape of 150 genetic drivers of the disease. We characterized the functional impact of these genes using an unbiased CRISPR screen of DLBCL cell lines to define oncogenes that promote cell growth. A prognostic model comprising these genetic alterations outperformed current established methods: cell of origin, the International Prognostic Index comprising clinical variables, and dual MYC and BCL2 expression. These results comprehensively define the genetic drivers and their functional roles in DLBCL to identify new therapeutic opportunities in the disease.

AB - Diffuse large B cell lymphoma (DLBCL) is the most common form of blood cancer and is characterized by a striking degree of genetic and clinical heterogeneity. This heterogeneity poses a major barrier to understanding the genetic basis of the disease and its response to therapy. Here, we performed an integrative analysis of whole-exome sequencing and transcriptome sequencing in a cohort of 1,001 DLBCL patients to comprehensively define the landscape of 150 genetic drivers of the disease. We characterized the functional impact of these genes using an unbiased CRISPR screen of DLBCL cell lines to define oncogenes that promote cell growth. A prognostic model comprising these genetic alterations outperformed current established methods: cell of origin, the International Prognostic Index comprising clinical variables, and dual MYC and BCL2 expression. These results comprehensively define the genetic drivers and their functional roles in DLBCL to identify new therapeutic opportunities in the disease.

KW - Antineoplastic Agents

KW - CRISPR-Cas Systems

KW - Cell Line, Tumor

KW - Cells, Cultured

KW - Exome

KW - Female

KW - Gene Expression Profiling

KW - Humans

KW - Lymphoma, Large B-Cell, Diffuse

KW - Male

KW - Rituximab

KW - Journal Article

U2 - 10.1016/j.cell.2017.09.027

DO - 10.1016/j.cell.2017.09.027

M3 - Journal article

VL - 171

SP - 481-494.e15

JO - Cell

JF - Cell

SN - 0092-8674

IS - 2

ER -

ID: 52353183