Genetic and epigenetic similarities and differences between childhood and adult AML

Caroline Juhl-Christensen; Hans Beier Ommen; Anni Aggerholm; Birgitte Lausen; Eigil Kjeldsen; Henrik Hasle; Peter Hokland

doi:10.1002/pbc.23397

Genetic and epigenetic similarities and differences between childhood and adult AML

Caroline Juhl-Christensen, Hans Beier Ommen, Anni Aggerholm, Birgitte Lausen, Eigil Kjeldsen, Henrik Hasle, Peter Hokland

Afdeling for Børn og Unge JMC

33 Citationer (Scopus)

Abstract

The biology of acute myeloid leukemia (AML) is complex and includes both genetic and epigenetic aberrations. We addressed the combined consequences of promoter hypermethylation of p15, CDH1, ER, MDR1, and RARB2 and mutation of NPM1, CEBPA, FLT3, and WT1 in a Danish cohort of 70 pediatric and 383 adult AML patients.

Originalsprog	Engelsk
Tidsskrift	Pediatric Blood & Cancer
Vol/bind	58
Udgave nummer	4
Sider (fra-til)	525-31
Antal sider	7
ISSN	1545-5009
DOI	https://doi.org/10.1002/pbc.23397
Status	Udgivet - 2012

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10.1002/pbc.23397

Citationsformater

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title = "Genetic and epigenetic similarities and differences between childhood and adult AML",

abstract = "The biology of acute myeloid leukemia (AML) is complex and includes both genetic and epigenetic aberrations. We addressed the combined consequences of promoter hypermethylation of p15, CDH1, ER, MDR1, and RARB2 and mutation of NPM1, CEBPA, FLT3, and WT1 in a Danish cohort of 70 pediatric and 383 adult AML patients.",

author = "Caroline Juhl-Christensen and Ommen, {Hans Beier} and Anni Aggerholm and Birgitte Lausen and Eigil Kjeldsen and Henrik Hasle and Peter Hokland",

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T1 - Genetic and epigenetic similarities and differences between childhood and adult AML

AU - Juhl-Christensen, Caroline

AU - Ommen, Hans Beier

AU - Aggerholm, Anni

AU - Lausen, Birgitte

AU - Kjeldsen, Eigil

AU - Hasle, Henrik

AU - Hokland, Peter

PY - 2012

Y1 - 2012

N2 - The biology of acute myeloid leukemia (AML) is complex and includes both genetic and epigenetic aberrations. We addressed the combined consequences of promoter hypermethylation of p15, CDH1, ER, MDR1, and RARB2 and mutation of NPM1, CEBPA, FLT3, and WT1 in a Danish cohort of 70 pediatric and 383 adult AML patients.

AB - The biology of acute myeloid leukemia (AML) is complex and includes both genetic and epigenetic aberrations. We addressed the combined consequences of promoter hypermethylation of p15, CDH1, ER, MDR1, and RARB2 and mutation of NPM1, CEBPA, FLT3, and WT1 in a Danish cohort of 70 pediatric and 383 adult AML patients.

U2 - 10.1002/pbc.23397

DO - 10.1002/pbc.23397

M3 - Journal article

C2 - 22331798

SN - 1545-5009

VL - 58

SP - 525

EP - 531

JO - Pediatric Blood & Cancer

JF - Pediatric Blood & Cancer

IS - 4

ER -

Genetic and epigenetic similarities and differences between childhood and adult AML

Abstract

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