Genetic and epigenetic similarities and differences between childhood and adult AML

Caroline Juhl-Christensen, Hans Beier Ommen, Anni Aggerholm, Birgitte Lausen, Eigil Kjeldsen, Henrik Hasle, Peter Hokland

32 Citationer (Scopus)

Abstract

The biology of acute myeloid leukemia (AML) is complex and includes both genetic and epigenetic aberrations. We addressed the combined consequences of promoter hypermethylation of p15, CDH1, ER, MDR1, and RARB2 and mutation of NPM1, CEBPA, FLT3, and WT1 in a Danish cohort of 70 pediatric and 383 adult AML patients.
OriginalsprogEngelsk
TidsskriftPediatric Blood & Cancer
Vol/bind58
Udgave nummer4
Sider (fra-til)525-31
Antal sider7
ISSN1545-5009
DOI
StatusUdgivet - 2012

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