TY - JOUR
T1 - Genetic and epigenetic similarities and differences between childhood and adult AML
AU - Juhl-Christensen, Caroline
AU - Ommen, Hans Beier
AU - Aggerholm, Anni
AU - Lausen, Birgitte
AU - Kjeldsen, Eigil
AU - Hasle, Henrik
AU - Hokland, Peter
N1 - Copyright © 2011 Wiley Periodicals, Inc.
PY - 2012
Y1 - 2012
N2 - The biology of acute myeloid leukemia (AML) is complex and includes both genetic and epigenetic aberrations. We addressed the combined consequences of promoter hypermethylation of p15, CDH1, ER, MDR1, and RARB2 and mutation of NPM1, CEBPA, FLT3, and WT1 in a Danish cohort of 70 pediatric and 383 adult AML patients.
AB - The biology of acute myeloid leukemia (AML) is complex and includes both genetic and epigenetic aberrations. We addressed the combined consequences of promoter hypermethylation of p15, CDH1, ER, MDR1, and RARB2 and mutation of NPM1, CEBPA, FLT3, and WT1 in a Danish cohort of 70 pediatric and 383 adult AML patients.
U2 - 10.1002/pbc.23397
DO - 10.1002/pbc.23397
M3 - Journal article
C2 - 22331798
SN - 1545-5009
VL - 58
SP - 525
EP - 531
JO - Pediatric Blood & Cancer
JF - Pediatric Blood & Cancer
IS - 4
ER -