Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Genetic and environmental influences on adult human height across birth cohorts from 1886 to 1994

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Linking glycemic dysregulation in diabetes to symptoms, comorbidities, and genetics through EHR data mining

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Apolipoprotein M-bound sphingosine-1-phosphate regulates blood-brain barrier paracellular permeability and transcytosis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Computational and cellular studies reveal structural destabilization and degradation of MLH1 variants in Lynch syndrome

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Privatisation rescues function following loss of cooperation

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Increase in clinically recorded type 2 diabetes after colectomy

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. A Trans-ancestral Meta-Analysis of Genome-Wide Association Studies Reveals Loci Associated with Childhood Obesity

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Association of Birth Weight With Type 2 Diabetes and Glycemic Traits: A Mendelian Randomization Study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Genetic Determinants of Weight Loss After Bariatric Surgery

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Is abdominal obesity at baseline influencing weight changes in observational studies and during weight loss interventions?

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Aline Jelenkovic
  • Yoon-Mi Hur
  • Reijo Sund
  • Yoshie Yokoyama
  • Sisira H Siribaddana
  • Matthew Hotopf
  • Athula Sumathipala
  • Fruhling Rijsdijk
  • Qihua Tan
  • Dongfeng Zhang
  • Zengchang Pang
  • Sari Aaltonen
  • Kauko Heikkilä
  • Sevgi Y Öncel
  • Fazil Aliev
  • Esther Rebato
  • Adam D Tarnoki
  • David L Tarnoki
  • Kaare Christensen
  • Axel Skytthe
  • Kirsten O Kyvik
  • Judy L Silberg
  • Lindon J Eaves
  • Hermine H Maes
  • Tessa L Cutler
  • John L Hopper
  • Juan R Ordoñana
  • Juan F Sánchez-Romera
  • Lucia Colodro-Conde
  • Wendy Cozen
  • Amie E Hwang
  • Thomas M Mack
  • Joohon Sung
  • Yun-Mi Song
  • Sarah Yang
  • Kayoung Lee
  • Carol E Franz
  • William S Kremen
  • Michael J Lyons
  • Andreas Busjahn
  • Tracy L Nelson
  • Keith E Whitfield
  • Christian Kandler
  • Kerry L Jang
  • Margaret Gatz
  • David A Butler
  • Maria A Stazi
  • Corrado Fagnani
  • Cristina D'Ippolito
  • Glen E Duncan
  • Dedra Buchwald
  • Catherine A Derom
  • Robert F Vlietinck
  • Ruth Jf Loos
  • Nicholas G Martin
  • Sarah E Medland
  • Grant W Montgomery
  • Hoe-Uk Jeong
  • Gary E Swan
  • Ruth Krasnow
  • Patrik Ke Magnusson
  • Nancy L Pedersen
  • Anna K Dahl-Aslan
  • Tom A McAdams
  • Thalia C Eley
  • Alice M Gregory
  • Per Tynelius
  • Laura A Baker
  • Catherine Tuvblad
  • Gombojav Bayasgalan
  • Danshiitsoodol Narandalai
  • Paul Lichtenstein
  • Timothy D Spector
  • Massimo Mangino
  • Genevieve Lachance
  • Meike Bartels
  • Toos Cem van Beijsterveldt
  • Gonneke Willemsen
  • S Alexandra Burt
  • Kelly L Klump
  • Jennifer R Harris
  • Ingunn Brandt
  • Thomas Sevenius Nilsen
  • Robert F Krueger
  • Matt McGue
  • Shandell Pahlen
  • Robin P Corley
  • Jacob V B Hjelmborg
  • Jack H Goldberg
  • Yoshinori Iwatani
  • Mikio Watanabe
  • Chika Honda
  • Fujio Inui
  • Finn Rasmussen
  • Brooke M Huibregtse
  • Dorret I Boomsma
  • Thorkild I A Sørensen
  • Jaakko Kaprio
  • Karri Silventoinen
Vis graf over relationer

Human height variation is determined by genetic and environmental factors, but it remains unclear whether their influences differ across birth-year cohorts. We conducted an individual-based pooled analysis of 40 twin cohorts including 143,390 complete twin pairs born 1886-1994. Although genetic variance showed a generally increasing trend across the birth-year cohorts, heritability estimates (0.69-0.84 in men and 0.53-0.78 in women) did not present any clear pattern of secular changes. Comparing geographic-cultural regions (Europe, North America and Australia, and East Asia), total height variance was greatest in North America and Australia and lowest in East Asia, but no clear pattern in the heritability estimates across the birth-year cohorts emerged. Our findings do not support the hypothesis that heritability of height is lower in populations with low living standards than in affluent populations, nor that heritability of height will increase within a population as living standards improve.

OriginalsprogEngelsk
Artikelnummere20320
TidsskrifteLife
Vol/bind5
Udgave nummerDECEMBER2016
Sider (fra-til)14
ISSN2050-084X
DOI
StatusUdgivet - 14 dec. 2016

ID: 49568680