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Genetic analysis of an orbital metastasis from a primary hepatic neuroendocrine carcinoma

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@article{5da33015470f4a188d7562bf5bf44554,
title = "Genetic analysis of an orbital metastasis from a primary hepatic neuroendocrine carcinoma",
abstract = "A 71-year-old female with a known history of primary hepatic neuroendocrine carcinoma, presented with a visual defect, proptosis and restricted eye movements of the right eye. Biopsies from the orbit and from the primary hepatic neuroendocrine carcinoma showed similar morphological and immunohistochemical features, and high-resolution, array-based comparative genomic hybridization demonstrated loss of one copy each of chromosomes 3 and 18, and gain of 1q both in the primary hepatic neuroendocrine carcinoma and in the orbital tumour. The orbital mass was diagnosed as a metastasis from the primary hepatic neuroendocrine carcinoma. Primary hepatic neuroendocrine tumours are extremely rare, and the orbit is an extremely rare location for a neuroendocrine carcinoma metastasis. This is the first reported case of an orbital metastasis with origin from a primary hepatic neuroendocrine carcinoma.",
author = "Rasmussen, {Jacob {\O}} and {Von Holstein}, {Sara Linea} and Prause, {Jan U} and Ben Vainer and Hansen, {Alastair B} and Andr{\'e} Fehr and G{\"o}ran Stenman and Steffen Heegaard",
year = "2014",
month = "10",
doi = "10.3892/or.2014.3345",
language = "English",
volume = "32",
pages = "1447--50",
journal = "Oncology Reports",
issn = "1021-335X",
publisher = "Demetrios A./Spandidos Ed. & Pub",
number = "4",

}

RIS

TY - JOUR

T1 - Genetic analysis of an orbital metastasis from a primary hepatic neuroendocrine carcinoma

AU - Rasmussen, Jacob Ø

AU - Von Holstein, Sara Linea

AU - Prause, Jan U

AU - Vainer, Ben

AU - Hansen, Alastair B

AU - Fehr, André

AU - Stenman, Göran

AU - Heegaard, Steffen

PY - 2014/10

Y1 - 2014/10

N2 - A 71-year-old female with a known history of primary hepatic neuroendocrine carcinoma, presented with a visual defect, proptosis and restricted eye movements of the right eye. Biopsies from the orbit and from the primary hepatic neuroendocrine carcinoma showed similar morphological and immunohistochemical features, and high-resolution, array-based comparative genomic hybridization demonstrated loss of one copy each of chromosomes 3 and 18, and gain of 1q both in the primary hepatic neuroendocrine carcinoma and in the orbital tumour. The orbital mass was diagnosed as a metastasis from the primary hepatic neuroendocrine carcinoma. Primary hepatic neuroendocrine tumours are extremely rare, and the orbit is an extremely rare location for a neuroendocrine carcinoma metastasis. This is the first reported case of an orbital metastasis with origin from a primary hepatic neuroendocrine carcinoma.

AB - A 71-year-old female with a known history of primary hepatic neuroendocrine carcinoma, presented with a visual defect, proptosis and restricted eye movements of the right eye. Biopsies from the orbit and from the primary hepatic neuroendocrine carcinoma showed similar morphological and immunohistochemical features, and high-resolution, array-based comparative genomic hybridization demonstrated loss of one copy each of chromosomes 3 and 18, and gain of 1q both in the primary hepatic neuroendocrine carcinoma and in the orbital tumour. The orbital mass was diagnosed as a metastasis from the primary hepatic neuroendocrine carcinoma. Primary hepatic neuroendocrine tumours are extremely rare, and the orbit is an extremely rare location for a neuroendocrine carcinoma metastasis. This is the first reported case of an orbital metastasis with origin from a primary hepatic neuroendocrine carcinoma.

U2 - 10.3892/or.2014.3345

DO - 10.3892/or.2014.3345

M3 - Journal article

VL - 32

SP - 1447

EP - 1450

JO - Oncology Reports

JF - Oncology Reports

SN - 1021-335X

IS - 4

ER -

ID: 44663524