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Genetic analysis of an orbital metastasis from a primary hepatic neuroendocrine carcinoma

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Vis graf over relationer

A 71-year-old female with a known history of primary hepatic neuroendocrine carcinoma, presented with a visual defect, proptosis and restricted eye movements of the right eye. Biopsies from the orbit and from the primary hepatic neuroendocrine carcinoma showed similar morphological and immunohistochemical features, and high-resolution, array-based comparative genomic hybridization demonstrated loss of one copy each of chromosomes 3 and 18, and gain of 1q both in the primary hepatic neuroendocrine carcinoma and in the orbital tumour. The orbital mass was diagnosed as a metastasis from the primary hepatic neuroendocrine carcinoma. Primary hepatic neuroendocrine tumours are extremely rare, and the orbit is an extremely rare location for a neuroendocrine carcinoma metastasis. This is the first reported case of an orbital metastasis with origin from a primary hepatic neuroendocrine carcinoma.

OriginalsprogEngelsk
TidsskriftOncology Reports
Vol/bind32
Udgave nummer4
Sider (fra-til)1447-50
Antal sider4
ISSN1021-335X
DOI
StatusUdgivet - okt. 2014

ID: 44663524