Generation of spinocerebellar ataxia type 2 patient-derived iPSC line H271

Adele G Marthaler, Alisa Tubsuwan, Benjamin Schmid, Ulla B Poulsen, Poul Hyttel, Jørgen E Nielsen, Troels T Nielsen, Bjørn Holst

5 Citationer (Scopus)


Spinocerebellar ataxia type 2 (SCA2) is a neurodegenerative disease primarily affecting the cerebellum. Very little is known about the molecular mechanisms underlying the disease and, to date, no cure or treatment is available. Here, we demonstrate the generation of an induced pluripotent stem cell (iPSC) line of a SCA2 patient. The selected clone has been proven to be a bona fide iPSC line, which retains a normal karyotype. Due to its differentiation potential into neurons, this iPSC line will be a valuable tool in studying a disease-specific phenotype of SCA2.

TidsskriftStem Cell Research
Udgave nummer1
Sider (fra-til)159-61
Antal sider3
StatusUdgivet - jan. 2016


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