Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Gene therapy of T helper cells in HIV infection: mathematical model of the criteria for clinical effect.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskning

  1. Cardiovascular dynamics during head-up tilt assessed via pulsatile and non-pulsatile models

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Integrated Inflammatory Stress (ITIS) Model

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Matrix proof of flow, volume and mean transit time theorems for regional and compartmental systems

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer
This paper presents a mathematical analysis of the criteria for gene therapy of T helper cells to have a clinical effect on HIV infection. The analysis indicates that for such a therapy to be successful, it must protect the transduced cells against HIV-induced death. The transduced cells will not survive as a population if the gene therapy only blocks the spread of virus from transduced cells that become infected. The analysis also suggests that the degree of protection against disease-related cell death provided by the gene therapy is more important than the fraction cells that is initially transduced. If only a small fraction of the cells can be transduced, transduction of T helper cells and transduction of haematopoietic progenitor cells will result in the same steady-state level of transduced T helper cells. For gene therapy to be efficient against HIV infection, our analysis suggests that a 100% protection against viral escape must be obtained. The study also suggests that a gene therapy against HIV infection should be designed to give the transduced cells a partial but not necessarily total protection against HIV-induced cell death, and to avoid the production of viral mutants insensitive to the gene therapy.
Bidragets oversatte titelGene therapy of T helper cells in HIV infection: mathematical model of the criteria for clinical effect.
OriginalsprogEngelsk
TidsskriftBulletin of Mathematical Biology
Vol/bind59
Udgave nummer4
Sider (fra-til)725-745
Antal sider21
ISSN0092-8240
StatusUdgivet - 1997

ID: 32536217