Gene expression profiles of mouse spermatogenesis during recovery from irradiation

Fozia J Shah, Masami Tanaka, John E Nielsen, Teruaki Iwamoto, Shinichi Kobayashi, Niels E Skakkebaek, Henrik Leffers, Kristian Almstrup

16 Citationer (Scopus)

Abstract

Irradiation or chemotherapy that suspend normal spermatogenesis is commonly used to treat various cancers. Fortunately, spermatogenesis in many cases can be restored after such treatments but knowledge is limited about the re-initiation process. Earlier studies have described the cellular changes that happen during recovery from irradiation by means of histology. We have earlier generated gene expression profiles during induction of spermatogenesis in mouse postnatal developing testes and found a correlation between profiles and the expressing cell types. The aim of the present work was to utilize the link between expression profile and cell types to follow the cellular changes that occur during post-irradiation recovery of spermatogenesis in order to describe recovery by means of gene expression.
OriginalsprogEngelsk
TidsskriftReproductive Biology and Endocrinology
Vol/bind7
Sider (fra-til)130
ISSN1477-7827
DOI
StatusUdgivet - 1 jan. 2009

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