TY - JOUR
T1 - Gene-Based Analysis of Regionally Enriched Cortical Genes in GWAS Data Sets of Cognitive Traits and Psychiatric Disorders
AU - Ersland, Kari M
AU - Christoforou, Andrea
AU - Stansberg, Christine
AU - Espeseth, Thomas
AU - Mattheisen, Manuel
AU - Mattingsdal, Morten
AU - Hardarson, Gudmundur A
AU - Hansen, Thomas
AU - Fernandes, Carla P D
AU - Giddaluru, Sudheer
AU - Breuer, René
AU - Strohmaier, Jana
AU - Djurovic, Srdjan
AU - Nöthen, Markus M
AU - Rietschel, Marcella
AU - Lundervold, Astri J
AU - Werge, Thomas
AU - Cichon, Sven
AU - Andreassen, Ole A
AU - Reinvang, Ivar
AU - Steen, Vidar M
AU - Le Hellard, Stephanie
PY - 2012
Y1 - 2012
N2 - Despite its estimated high heritability, the genetic architecture leading to differences in cognitive performance remains poorly understood. Different cortical regions play important roles in normal cognitive functioning and impairment. Recently, we reported on sets of regionally enriched genes in three different cortical areas (frontomedial, temporal and occipital cortices) of the adult rat brain. It has been suggested that genes preferentially, or specifically, expressed in one region or organ reflect functional specialisation. Employing a gene-based approach to the analysis, we used the regionally enriched cortical genes to mine a genome-wide association study (GWAS) of the Norwegian Cognitive NeuroGenetics (NCNG) sample of healthy adults for association to nine psychometric tests measures. In addition, we explored GWAS data sets for the serious psychiatric disorders schizophrenia (SCZ) (n = 3 samples) and bipolar affective disorder (BP) (n = 3 samples), to which cognitive impairment is linked.
AB - Despite its estimated high heritability, the genetic architecture leading to differences in cognitive performance remains poorly understood. Different cortical regions play important roles in normal cognitive functioning and impairment. Recently, we reported on sets of regionally enriched genes in three different cortical areas (frontomedial, temporal and occipital cortices) of the adult rat brain. It has been suggested that genes preferentially, or specifically, expressed in one region or organ reflect functional specialisation. Employing a gene-based approach to the analysis, we used the regionally enriched cortical genes to mine a genome-wide association study (GWAS) of the Norwegian Cognitive NeuroGenetics (NCNG) sample of healthy adults for association to nine psychometric tests measures. In addition, we explored GWAS data sets for the serious psychiatric disorders schizophrenia (SCZ) (n = 3 samples) and bipolar affective disorder (BP) (n = 3 samples), to which cognitive impairment is linked.
U2 - 10.1371/journal.pone.0031687
DO - 10.1371/journal.pone.0031687
M3 - Journal article
C2 - 22384057
SN - 1932-6203
VL - 7
SP - e31687
JO - P L o S One
JF - P L o S One
IS - 2
ER -