Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Gender difference in breast tissue size in infancy: correlation with serum estradiol

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Cerebral oxygenation and blood flow in normal term infants at rest measured by a hybrid near-infrared device (BabyLux)

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Co-occurrence of infantile hypertrophic pyloric stenosis and congenital heart defects: a nationwide cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Serum, plasma and erythrocyte membrane lipidomes in infants fed formula supplemented with bovine milk fat globule membranes

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. NKG2D gene variation and susceptibility to viral bronchiolitis in childhood

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Sex-specific estrogen levels and reference intervals from infancy to late adulthood determined by LC-MS/MS

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Bone mineral density is preserved in men with idiopathic infertility

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Impact of Service User Involvement from the Perspective of Adolescents and Young Adults with Cancer Experience

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. CENTRAL PRECOCIOUS PUBERTY IN TWO BOYS WITH PRADER-WILLI SYNDROME ON GROWTH HORMONE TREATMENT

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Breast tissue in newborn infants is considered to be physiologic and mainly related to exposure to maternal hormones in utero or through breast-feeding. However, controversy exists as to whether breast tissue in later infancy is under the influence of endogenous hormones. Children at 2-4 mo of age have a surge of reproductive hormones, including estradiol, which may affect the mammary gland. In a prospective cohort study of 1126 healthy, 3-mo-old infants, breast tissue size and reproductive hormones were measured. We found that palpable breast tissue (diameter >or=3 mm) is a common physiologic condition present in 78.9% of children, significantly more frequent (p < 0.001) and larger (p < 0.001) in girls than in boys. Girls had significantly higher median estradiol levels than boys (30.0 versus 21.0 pmol/L, p < 0.001). In a multiple regression model including breast tissue size given as quartiles as the dependent variable and weight for gestational age, subscapular skinfold, weight at 3 mo of age and serum estradiol as independent variables, a gender difference was shown. In girls, the estradiol level was positively (p < 0.03) correlated to breast quartile. In boys, no correlations were found. Whether the stimulation of the mammary gland in infancy represents a developmental window that is of biologic significance for breast development and pathology in adulthood remains to be defined.

OriginalsprogEngelsk
TidsskriftPediatric Research
Vol/bind52
Udgave nummer5
Sider (fra-til)682-6
Antal sider5
ISSN0031-3998
DOI
StatusUdgivet - nov. 2002

ID: 51497654