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Gastrointestinal Applications of Iodine Quantification Using Dual-Energy CT: A Systematic Review

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@article{4c48f5f256f4474a80dadb84401c641c,
title = "Gastrointestinal Applications of Iodine Quantification Using Dual-Energy CT: A Systematic Review",
abstract = "Dual-energy computed tomography (DECT) can estimate tissue vascularity and perfusion via iodine quantification. The aim of this systematic review was to outline current and emerging clinical applications of iodine quantification within the gastrointestinal tract using DECT. The search was conducted with three databases: EMBASE, Pubmed and The Cochrane Library. This identified 449 studies after duplicate removal. From a total of 570 selected studies, 30 studies were enrolled for the systematic review. The studies were categorized into four main topics: gastric tumors (12 studies), colorectal tumors (8 studies), Crohn's disease (4 studies) and miscellaneous applications (6 studies). Findings included a significant difference in iodine concentration (IC) measurements in perigastric fat between T1-3 vs. T4 stage gastric cancer, poorly and well differentiated gastric and colorectal cancer, responders vs. non-responders following chemo- or chemoradiotherapy treatment among cancer patients, and a positive correlation between IC and Crohn's disease activity. In conclusion, iodine quantification with DECT may be used preoperatively in cancer imaging as well as for monitoring treatment response. Future studies are warranted to evaluate the capabilities and limitations of DECT in splanchnic flow.",
author = "Xu, {Jack Junchi} and Mikkel Taudorf and Ulriksen, {Peter Sommer} and Achiam, {Michael Patrick} and Resch, {Timothy Andrew} and Nielsen, {Michael Bachmann} and L{\"o}nn, {Lars Birger} and Hansen, {Kristoffer Lindskov}",
year = "2020",
month = oct,
day = "13",
doi = "10.3390/diagnostics10100814",
language = "English",
volume = "10",
pages = "814",
journal = "Diagnostics",
issn = "2075-4418",
publisher = "M D P I AG",
number = "10",

}

RIS

TY - JOUR

T1 - Gastrointestinal Applications of Iodine Quantification Using Dual-Energy CT

T2 - A Systematic Review

AU - Xu, Jack Junchi

AU - Taudorf, Mikkel

AU - Ulriksen, Peter Sommer

AU - Achiam, Michael Patrick

AU - Resch, Timothy Andrew

AU - Nielsen, Michael Bachmann

AU - Lönn, Lars Birger

AU - Hansen, Kristoffer Lindskov

PY - 2020/10/13

Y1 - 2020/10/13

N2 - Dual-energy computed tomography (DECT) can estimate tissue vascularity and perfusion via iodine quantification. The aim of this systematic review was to outline current and emerging clinical applications of iodine quantification within the gastrointestinal tract using DECT. The search was conducted with three databases: EMBASE, Pubmed and The Cochrane Library. This identified 449 studies after duplicate removal. From a total of 570 selected studies, 30 studies were enrolled for the systematic review. The studies were categorized into four main topics: gastric tumors (12 studies), colorectal tumors (8 studies), Crohn's disease (4 studies) and miscellaneous applications (6 studies). Findings included a significant difference in iodine concentration (IC) measurements in perigastric fat between T1-3 vs. T4 stage gastric cancer, poorly and well differentiated gastric and colorectal cancer, responders vs. non-responders following chemo- or chemoradiotherapy treatment among cancer patients, and a positive correlation between IC and Crohn's disease activity. In conclusion, iodine quantification with DECT may be used preoperatively in cancer imaging as well as for monitoring treatment response. Future studies are warranted to evaluate the capabilities and limitations of DECT in splanchnic flow.

AB - Dual-energy computed tomography (DECT) can estimate tissue vascularity and perfusion via iodine quantification. The aim of this systematic review was to outline current and emerging clinical applications of iodine quantification within the gastrointestinal tract using DECT. The search was conducted with three databases: EMBASE, Pubmed and The Cochrane Library. This identified 449 studies after duplicate removal. From a total of 570 selected studies, 30 studies were enrolled for the systematic review. The studies were categorized into four main topics: gastric tumors (12 studies), colorectal tumors (8 studies), Crohn's disease (4 studies) and miscellaneous applications (6 studies). Findings included a significant difference in iodine concentration (IC) measurements in perigastric fat between T1-3 vs. T4 stage gastric cancer, poorly and well differentiated gastric and colorectal cancer, responders vs. non-responders following chemo- or chemoradiotherapy treatment among cancer patients, and a positive correlation between IC and Crohn's disease activity. In conclusion, iodine quantification with DECT may be used preoperatively in cancer imaging as well as for monitoring treatment response. Future studies are warranted to evaluate the capabilities and limitations of DECT in splanchnic flow.

U2 - 10.3390/diagnostics10100814

DO - 10.3390/diagnostics10100814

M3 - Review

C2 - 33066281

VL - 10

SP - 814

JO - Diagnostics

JF - Diagnostics

SN - 2075-4418

IS - 10

ER -

ID: 61290576