TY - JOUR
T1 - Gasotransmitters and the immune system
T2 - Mode of action and novel therapeutic targets
AU - Fagone, Paolo
AU - Mazzon, Emanuela
AU - Bramanti, Placido
AU - Bendtzen, Klaus
AU - Nicoletti, Ferdinando
N1 - Copyright © 2018 The Authors. Published by Elsevier B.V. All rights reserved.
PY - 2018/9/5
Y1 - 2018/9/5
N2 - Gasotransmitters are a group of gaseous molecules, with pleiotropic biological functions. These molecules include nitric oxide (NO), hydrogen sulfide (H2S), and carbon monoxide (CO). Abnormal production and metabolism of these molecules have been observed in several pathological conditions. The understanding of the role of gasotransmitters in the immune system has grown significantly in the past years, and independent studies have shed light on the effect of exogenous and endogenous gasotransmitters on immune responses. Moreover, encouraging results come from the efficacy of NO-, CO- and H2S -donors in preclinical animal models of autoimmune, acute and chronic inflammatory diseases. To date, data on the influence of gasotransmitters in immunity and immunopathology are often scattered and partial, and the scarcity of clinical trials using NO-, CO- and H2S -donors, reveals that more effort is warranted. This review focuses on the role of gasotransmitters in the immune system and covers the evidences on the possible use of gasotransmitters for the treatment of inflammatory conditions.
AB - Gasotransmitters are a group of gaseous molecules, with pleiotropic biological functions. These molecules include nitric oxide (NO), hydrogen sulfide (H2S), and carbon monoxide (CO). Abnormal production and metabolism of these molecules have been observed in several pathological conditions. The understanding of the role of gasotransmitters in the immune system has grown significantly in the past years, and independent studies have shed light on the effect of exogenous and endogenous gasotransmitters on immune responses. Moreover, encouraging results come from the efficacy of NO-, CO- and H2S -donors in preclinical animal models of autoimmune, acute and chronic inflammatory diseases. To date, data on the influence of gasotransmitters in immunity and immunopathology are often scattered and partial, and the scarcity of clinical trials using NO-, CO- and H2S -donors, reveals that more effort is warranted. This review focuses on the role of gasotransmitters in the immune system and covers the evidences on the possible use of gasotransmitters for the treatment of inflammatory conditions.
KW - Animals
KW - Gasotransmitters/metabolism
KW - Humans
KW - Immune System/drug effects
KW - Molecular Targeted Therapy/methods
U2 - 10.1016/j.ejphar.2018.07.026
DO - 10.1016/j.ejphar.2018.07.026
M3 - Journal article
C2 - 30016662
VL - 834
SP - 92
EP - 102
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
SN - 0014-2999
ER -